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• W4317777588 abstract "This study describes macro- and micro-sleep responses to a myotoxic skeletal muscle injury and investigates possible mechanisms.We recorded the electroencephalogram (EEG)/electromyogram (EMG) of 24 Wistar rats before and after induction of tibialis anterior muscle injury (n = 8 per group: control, control + buprenorphine and injured). A top-down analysis of sleep characteristics was processed from total sleep time (TST), sleep stages, sleep stability, spectral analysis, and spindles. To further investigate the mechanisms involved, we analyzed the protein level of sleep regulatory molecules including tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), insulin-like growth factor-1 (IGF-1), and brain and muscle ARNT-like 1 (BMAL1) in plasma, frontal cortex, hippocampus, and tibialis anterior, collected at day +2 after injury from non-EEG/EMG implanted rats.Muscle injury induces a significant increase in TST at 48 and 72 h post-injury, specific to non-rapid eye movement (NREM) sleep. These increases occur during the dark period and are associated with the higher stability of sleep over 24 h, without change in the different power/frequency spectral bands of NREM/REM sleep. There was no corresponding sleep increase in slow-wave activity or spindle density, nor were there changes in brain levels of the sleep-regulating proinflammatory cytokine IL-1β, which is otherwise involved in the local response to injury. Conversely, decreased protein levels of brain IGF-1 and muscle BMAL1, a core circadian clock gene, after injury may play a role in increased sleep time.Muscle injury induces an increase in total sleep time at 48- and 72-h post-injury, specific to NREM sleep during the dark period in rats and is associated with higher sleep stability over 24 h." @default.
• W4317777588 created "2023-01-24" @default.
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• W4317777588 date "2023-01-23" @default.
• W4317777588 modified "2023-10-18" @default.
• W4317777588 title "Muscle injury induces an increase in total and non-rapid eye movement sleep time" @default.
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• W4317777588 doi "https://doi.org/10.1093/sleep/zsad012" @default.
• W4317777588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36688830" @default.
• W4317777588 hasPublicationYear "2023" @default.
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