Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317787046> ?p ?o ?g. }
- W4317787046 abstract "Abstract Background Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the limited therapies available. However, only a subgroup of metastases uses sprouting angiogenesis to secure their nutrients and oxygen supply, while others rely on vessel co-option (VCO). The distinct mode of vascularization is reflected by specific histopathological growth patterns (HGPs), which have proven prognostic and predictive significance. Nevertheless, their molecular mechanisms are poorly understood. Methods We evaluated CRCLM from 225 patients regarding their HGP and clinical data. Moreover, we performed spatial (21,804 spots) and single-cell (22,419 cells) RNA sequencing analyses to explore molecular differences in detail, further validated in vitro through immunohistochemical analysis and patient-derived organoid cultures. Results We detected specific metabolic alterations and a signature of WNT signalling activation in metastatic cancer cells related to the VCO phenotype. Importantly, in the corresponding healthy liver of CRCLM displaying sprouting angiogenesis, we identified a predominantly expressed capillary subtype of endothelial cells, which could be further explored as a possible predictor for HGP relying on sprouting angiogenesis. Conclusion These findings may prove to be novel therapeutic targets to the treatment of CRCLM, in special the ones relying on VCO." @default.
- W4317787046 created "2023-01-24" @default.
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- W4317787046 date "2023-01-24" @default.
- W4317787046 modified "2023-10-16" @default.
- W4317787046 title "Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution" @default.
- W4317787046 cites W1483496013 @default.
- W4317787046 cites W1597158509 @default.
- W4317787046 cites W1967968626 @default.
- W4317787046 cites W1985804036 @default.
- W4317787046 cites W1994250985 @default.
- W4317787046 cites W2000467897 @default.
- W4317787046 cites W2002513358 @default.
- W4317787046 cites W2035312349 @default.
- W4317787046 cites W2041291777 @default.
- W4317787046 cites W2046434779 @default.
- W4317787046 cites W2055648088 @default.
- W4317787046 cites W2065672772 @default.
- W4317787046 cites W2075340577 @default.
- W4317787046 cites W2085813570 @default.
- W4317787046 cites W2086320398 @default.
- W4317787046 cites W2090883050 @default.
- W4317787046 cites W2094952351 @default.
- W4317787046 cites W2097481786 @default.
- W4317787046 cites W2107018762 @default.
- W4317787046 cites W2111180661 @default.
- W4317787046 cites W2123106337 @default.
- W4317787046 cites W2124000950 @default.
- W4317787046 cites W2130116522 @default.
- W4317787046 cites W2130410032 @default.
- W4317787046 cites W2133469704 @default.
- W4317787046 cites W2133707124 @default.
- W4317787046 cites W2140992718 @default.
- W4317787046 cites W2141461285 @default.
- W4317787046 cites W2157157634 @default.
- W4317787046 cites W2234115940 @default.
- W4317787046 cites W2237670736 @default.
- W4317787046 cites W2496573967 @default.
- W4317787046 cites W2504746053 @default.
- W4317787046 cites W2520632143 @default.
- W4317787046 cites W2522144811 @default.
- W4317787046 cites W2533236332 @default.
- W4317787046 cites W2569369624 @default.
- W4317787046 cites W2595257297 @default.
- W4317787046 cites W2606607500 @default.
- W4317787046 cites W2612372140 @default.
- W4317787046 cites W2619876526 @default.
- W4317787046 cites W2729671103 @default.
- W4317787046 cites W2761998606 @default.
- W4317787046 cites W2766366755 @default.
- W4317787046 cites W2791965482 @default.
- W4317787046 cites W2801609626 @default.
- W4317787046 cites W2808837841 @default.
- W4317787046 cites W2896804634 @default.
- W4317787046 cites W2898321887 @default.
- W4317787046 cites W2900166571 @default.
- W4317787046 cites W2910287064 @default.
- W4317787046 cites W2918664065 @default.
- W4317787046 cites W2945968067 @default.
- W4317787046 cites W2946322395 @default.
- W4317787046 cites W2954220199 @default.
- W4317787046 cites W2969862048 @default.
- W4317787046 cites W2970253393 @default.
- W4317787046 cites W2982360975 @default.
- W4317787046 cites W3006650868 @default.
- W4317787046 cites W3009721059 @default.
- W4317787046 cites W3016911576 @default.
- W4317787046 cites W3033089248 @default.
- W4317787046 cites W3040660865 @default.
- W4317787046 cites W3081768459 @default.
- W4317787046 cites W3089307410 @default.
- W4317787046 cites W3092702002 @default.
- W4317787046 cites W3102511407 @default.
- W4317787046 cites W3115420440 @default.
- W4317787046 cites W3119005666 @default.
- W4317787046 cites W3121918086 @default.
- W4317787046 cites W3125308934 @default.
- W4317787046 cites W3126396267 @default.
- W4317787046 cites W3128646645 @default.
- W4317787046 cites W3135997845 @default.
- W4317787046 cites W3136646547 @default.
- W4317787046 cites W3165411814 @default.
- W4317787046 cites W3167802990 @default.