Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317814895> ?p ?o ?g. }
- W4317814895 abstract "In the field of biomaterials, an endosseous implant is now recognized as an osteoimmunomodulatory but not bioinert biomaterial. Scientific advances in bone cell biology and in immunology have revealed a close relationship between the bone and immune systems resulting in a field of science called osteoimmunology. These discoveries have allowed for a novel interpretation of osseointegration as representing an osteoimmune reaction rather than a classic bone healing response, in which the activation state of macrophages ((M1–M2 polarization) appears to play a critical role. Through this viewpoint, the immune system is responsible for isolating the implant biomaterial foreign body by forming bone around the oral implant effectively shielding off the implant from the host bone system, i.e. osseointegration becomes a continuous and dynamic host defense reaction. At the same time, this has led to the proposal of a new model of osseointegration, the foreign body equilibrium (FBE). In addition, as an oral wound, the soft tissues are involved with all their innate immune characteristics. When implant integration is viewed as an osteoimmune reaction, this has implications for how marginal bone is regulated. For example, while bacteria are constitutive components of the soft tissue sulcus, if the inflammatory front and immune reaction is at some distance from the marginal bone, an equilibrium is established. If however, this inflammation approaches the marginal bone, an immune osteoclastic reaction occurs and marginal bone is removed. A number of clinical scenarios can be envisioned whereby the osteoimmune equilibrium is disturbed and marginal bone loss occurs, such as complications of aseptic nature and the synergistic activation of pro-inflammatory pathways (implant/wear debris, DAMPs, and PAMPs). Understanding that an implant is a foreign body and that the host reacts osteoimmunologically to shield off the implant allows for a distinction to be drawn between osteoimmunological conditions and peri-implant bone loss. This review will examine dental implant placement as an osteoimmune reaction and its implications for marginal bone loss." @default.
- W4317814895 created "2023-01-24" @default.
- W4317814895 creator A5026791343 @default.
- W4317814895 creator A5041198612 @default.
- W4317814895 creator A5044952842 @default.
- W4317814895 creator A5048483489 @default.
- W4317814895 creator A5052148012 @default.
- W4317814895 creator A5054510527 @default.
- W4317814895 date "2023-01-24" @default.
- W4317814895 modified "2023-10-18" @default.
- W4317814895 title "Osteoimmune regulation underlies oral implant osseointegration and its perturbation" @default.
- W4317814895 cites W1525531948 @default.
- W4317814895 cites W1575658306 @default.
- W4317814895 cites W1604044665 @default.
- W4317814895 cites W1728757149 @default.
- W4317814895 cites W1817443571 @default.
- W4317814895 cites W1839839841 @default.
- W4317814895 cites W1842271345 @default.
- W4317814895 cites W1921568882 @default.
- W4317814895 cites W193520275 @default.
- W4317814895 cites W1956176311 @default.
- W4317814895 cites W1964059429 @default.
- W4317814895 cites W1965696823 @default.
- W4317814895 cites W1973910899 @default.
- W4317814895 cites W1979164497 @default.
- W4317814895 cites W1982395713 @default.
- W4317814895 cites W1984612413 @default.
- W4317814895 cites W1999559229 @default.
- W4317814895 cites W2005794914 @default.
- W4317814895 cites W2007296728 @default.
- W4317814895 cites W2010690419 @default.
- W4317814895 cites W2029283111 @default.
- W4317814895 cites W2036932056 @default.
- W4317814895 cites W2047512912 @default.
- W4317814895 cites W2056773589 @default.
- W4317814895 cites W2056984295 @default.
- W4317814895 cites W2062180222 @default.
- W4317814895 cites W2070793750 @default.
- W4317814895 cites W2078796379 @default.
- W4317814895 cites W2079347404 @default.
- W4317814895 cites W2084385377 @default.
- W4317814895 cites W2084751257 @default.
- W4317814895 cites W2085675651 @default.
- W4317814895 cites W2091441664 @default.
- W4317814895 cites W2104357139 @default.
- W4317814895 cites W2104889291 @default.
- W4317814895 cites W2117851762 @default.
- W4317814895 cites W2129277103 @default.
- W4317814895 cites W2130443006 @default.
- W4317814895 cites W2131278293 @default.
- W4317814895 cites W2133475573 @default.
- W4317814895 cites W2134685432 @default.
- W4317814895 cites W2145252505 @default.
- W4317814895 cites W2148088763 @default.
- W4317814895 cites W2148423504 @default.
- W4317814895 cites W2151005356 @default.
- W4317814895 cites W2162835535 @default.
- W4317814895 cites W2174617543 @default.
- W4317814895 cites W2194806179 @default.
- W4317814895 cites W2233019931 @default.
- W4317814895 cites W2291429897 @default.
- W4317814895 cites W2299472426 @default.
- W4317814895 cites W2309945771 @default.
- W4317814895 cites W2332707160 @default.
- W4317814895 cites W2419340363 @default.
- W4317814895 cites W2461886685 @default.
- W4317814895 cites W2471738476 @default.
- W4317814895 cites W2472601311 @default.
- W4317814895 cites W2498125942 @default.
- W4317814895 cites W2522157139 @default.
- W4317814895 cites W2550088712 @default.
- W4317814895 cites W2557980464 @default.
- W4317814895 cites W2560297837 @default.
- W4317814895 cites W2570345471 @default.
- W4317814895 cites W2590599688 @default.
- W4317814895 cites W2601594867 @default.
- W4317814895 cites W2715483000 @default.
- W4317814895 cites W2736948430 @default.
- W4317814895 cites W2745329336 @default.
- W4317814895 cites W2770072920 @default.
- W4317814895 cites W2777717412 @default.
- W4317814895 cites W2793011605 @default.
- W4317814895 cites W2794643103 @default.
- W4317814895 cites W2810075426 @default.
- W4317814895 cites W2894565780 @default.
- W4317814895 cites W2901394822 @default.
- W4317814895 cites W2901619572 @default.
- W4317814895 cites W2902823946 @default.
- W4317814895 cites W2904929985 @default.
- W4317814895 cites W2907008684 @default.
- W4317814895 cites W2912002734 @default.
- W4317814895 cites W2913901380 @default.
- W4317814895 cites W2922244106 @default.
- W4317814895 cites W2926939932 @default.
- W4317814895 cites W2947352434 @default.
- W4317814895 cites W2948438024 @default.
- W4317814895 cites W2960775204 @default.
- W4317814895 cites W2964930535 @default.
- W4317814895 cites W2969990165 @default.
- W4317814895 cites W2971901669 @default.