FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317869589> ?p ?o ?g. }

• W4317869589 endingPage "137092" @default.
• W4317869589 startingPage "137092" @default.
• W4317869589 abstract "Depression underlies a common psychiatric disorder that has been rising in the diagnosis of long-term disabilities worldwide. Natural products have been studied as an antidepressant and anxiolytic agents aiming to make available new options for the daily basis treatment of those psychological disorders. SteLL is a lectin extracted from Schinus terebinthifolia leaf that has been revealed as an antimicrobial, immunomodulatory, antitumor, and antinociceptive agent. Nonetheless, the efficacy of SteLL in the treatment of depression has not yet been explored. In view of this, the aim of this study was to investigate the effect of SteLL in an acute protocol for symptoms of depression using the tail suspension test (TST) to assess despair. Administration of SteLL (1, 2 e 4 mg/kg) significantly diminished the immobility time of animals in the TST and this anti-immobility action was dependent on the carbohydrate-recognizing domain (CRD) since the prior incubation with casein (an inhibitor of SteLL carbohydrate-binding property) blocked the effect. SteLL effect was also reversed by pre-treatment with pharmacological antagonists of α2-adrenoceptor, 5-HT2A/2C serotonin receptor, and D1 dopamine receptor as well as by a selective inhibitor of iNOS (aminoguanidine). l-arginine, a precursor of NO, potentiated SteLL anti-immobility effect. In a subacute evaluation, the anti-immobility effect of SteLL persisted after seven days of treatment. Our findings suggest a role of SteLL in the modulation of depression mostly through monoaminergic and nitric oxide signaling." @default.
• W4317869589 created "2023-01-25" @default.
• W4317869589 creator A5005066510 @default.
• W4317869589 creator A5009815389 @default.
• W4317869589 creator A5011237234 @default.
• W4317869589 creator A5067684284 @default.
• W4317869589 creator A5069273645 @default.
• W4317869589 creator A5086637580 @default.
• W4317869589 creator A5086850665 @default.
• W4317869589 date "2023-03-01" @default.
• W4317869589 modified "2023-10-14" @default.
• W4317869589 title "The lectin from Schinus terebinthifolia leaf (SteLL) reduces immobility of mice on the tail suspension test dependent on the monoaminergic and nitric oxide signaling" @default.
• W4317869589 cites W1775749144 @default.
• W4317869589 cites W1967037400 @default.
• W4317869589 cites W1971251151 @default.
• W4317869589 cites W1971475230 @default.
• W4317869589 cites W1987222018 @default.
• W4317869589 cites W1987798935 @default.
• W4317869589 cites W2002403208 @default.
• W4317869589 cites W2022980508 @default.
• W4317869589 cites W2026779396 @default.
• W4317869589 cites W2037111632 @default.
• W4317869589 cites W2053472601 @default.
• W4317869589 cites W2054939193 @default.
• W4317869589 cites W2059101370 @default.
• W4317869589 cites W2071262531 @default.
• W4317869589 cites W2090344130 @default.
• W4317869589 cites W2100837269 @default.
• W4317869589 cites W2123290069 @default.
• W4317869589 cites W2166890356 @default.
• W4317869589 cites W2178380109 @default.
• W4317869589 cites W2539812162 @default.
• W4317869589 cites W2745962230 @default.
• W4317869589 cites W2766059362 @default.
• W4317869589 cites W2766194567 @default.
• W4317869589 cites W2789034326 @default.
• W4317869589 cites W2791314673 @default.
• W4317869589 cites W2793950820 @default.
• W4317869589 cites W2884641336 @default.
• W4317869589 cites W2910086534 @default.
• W4317869589 cites W2977895995 @default.
• W4317869589 cites W2980982546 @default.
• W4317869589 cites W2992990537 @default.
• W4317869589 cites W3010639554 @default.
• W4317869589 cites W3033447508 @default.
• W4317869589 cites W3089498131 @default.
• W4317869589 cites W3161383500 @default.
• W4317869589 cites W3186873814 @default.
• W4317869589 cites W3201827191 @default.
• W4317869589 cites W3214509613 @default.
• W4317869589 cites W4220839020 @default.
• W4317869589 cites W4226178612 @default.
• W4317869589 cites W4289717329 @default.
• W4317869589 cites W4292963246 @default.
• W4317869589 cites W4304128453 @default.
• W4317869589 cites W4308510038 @default.
• W4317869589 doi "https://doi.org/10.1016/j.neulet.2023.137092" @default.
• W4317869589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36690060" @default.
• W4317869589 hasPublicationYear "2023" @default.
• W4317869589 type Work @default.
• W4317869589 citedByCount "1" @default.
• W4317869589 countsByYear W43178695892023 @default.
• W4317869589 crossrefType "journal-article" @default.
• W4317869589 hasAuthorship W4317869589A5005066510 @default.
• W4317869589 hasAuthorship W4317869589A5009815389 @default.
• W4317869589 hasAuthorship W4317869589A5011237234 @default.
• W4317869589 hasAuthorship W4317869589A5067684284 @default.
• W4317869589 hasAuthorship W4317869589A5069273645 @default.
• W4317869589 hasAuthorship W4317869589A5086637580 @default.
• W4317869589 hasAuthorship W4317869589A5086850665 @default.
• W4317869589 hasConcept C126322002 @default.
• W4317869589 hasConcept C134018914 @default.
• W4317869589 hasConcept C136569192 @default.
• W4317869589 hasConcept C170493617 @default.
• W4317869589 hasConcept C2775864247 @default.
• W4317869589 hasConcept C2777765862 @default.
• W4317869589 hasConcept C2779177272 @default.
• W4317869589 hasConcept C2781001258 @default.
• W4317869589 hasConcept C2781161787 @default.
• W4317869589 hasConcept C42251903 @default.
• W4317869589 hasConcept C513476851 @default.
• W4317869589 hasConcept C519581460 @default.
• W4317869589 hasConcept C71924100 @default.
• W4317869589 hasConcept C98274493 @default.
• W4317869589 hasConceptScore W4317869589C126322002 @default.
• W4317869589 hasConceptScore W4317869589C134018914 @default.
• W4317869589 hasConceptScore W4317869589C136569192 @default.
• W4317869589 hasConceptScore W4317869589C170493617 @default.
• W4317869589 hasConceptScore W4317869589C2775864247 @default.
• W4317869589 hasConceptScore W4317869589C2777765862 @default.
• W4317869589 hasConceptScore W4317869589C2779177272 @default.
• W4317869589 hasConceptScore W4317869589C2781001258 @default.
• W4317869589 hasConceptScore W4317869589C2781161787 @default.
• W4317869589 hasConceptScore W4317869589C42251903 @default.
• W4317869589 hasConceptScore W4317869589C513476851 @default.
• W4317869589 hasConceptScore W4317869589C519581460 @default.
• W4317869589 hasConceptScore W4317869589C71924100 @default.
• W4317869589 hasConceptScore W4317869589C98274493 @default.

• next