FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317874818> ?p ?o ?g. }

• W4317874818 endingPage "3107" @default.
• W4317874818 startingPage "3098" @default.
• W4317874818 abstract "Nowadays, infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have constituted a new challenge for anti-infective treatment. Precise identification and rapid clinical diagnostics of MRSA from other methicillin-sensitive strains entail assays with robust diagnostic efficiency and simple operation steps. Sensitive detection of MecA gene is promising to indicate MRSA infection, but it is challenged by the lack of isothermal and simple strategies. A visual assay based on isothermal rolling circular amplification and G-quadruplex/hemin (G4/hemin) DNAzyme proximity assembly was proposed for the immediate, efficient, and cost-effective detection of MecA in simple operation steps and in a single tube. The presence of MecA specifically drove the formation of circular templates, which further triggered isothermal amplification. The amplified product offered abundant binding sites for DNA-grafted hemin probes to form a novel proximity-assembled G4/hemin DNAzyme structure for colorimetric changing diagnosis. This tandem-repeated novel DNAzyme possessed higher catalytic activity and a lower background signal than traditional G4/hemin DNAzyme, ensuring sensitive discrimination of MRSA (limit of detection: 9.6 pM). Assay stability and antimatrix interference capability enable clinical application, which shows compared diagnostic ability with classic methods (100% sensitivity and 100% specificity) but possesses more simplified procedures and shorter turnaround time (<6 h). This colorimetric strategy in a nonsite-specific and hypersensitive manner holds foreseeable prospects in clinical diagnostic and research applications." @default.
• W4317874818 created "2023-01-25" @default.
• W4317874818 creator A5016406818 @default.
• W4317874818 creator A5017508252 @default.
• W4317874818 creator A5025615497 @default.
• W4317874818 creator A5027996570 @default.
• W4317874818 creator A5031621087 @default.
• W4317874818 creator A5051897407 @default.
• W4317874818 creator A5053417739 @default.
• W4317874818 creator A5055115466 @default.
• W4317874818 creator A5056391726 @default.
• W4317874818 creator A5070285898 @default.
• W4317874818 creator A5073445421 @default.
• W4317874818 creator A5086419407 @default.
• W4317874818 date "2023-01-24" @default.
• W4317874818 modified "2023-10-15" @default.
• W4317874818 title "Visual Assay for Methicillin-Resistant <i>Staphylococcus aureus</i> Based on Rolling Circular Amplification Triggering G-Quadruplex/Hemin DNAzyme Proximity Assembly" @default.
• W4317874818 cites W1864055940 @default.
• W4317874818 cites W1968595280 @default.
• W4317874818 cites W1972454905 @default.
• W4317874818 cites W1985236738 @default.
• W4317874818 cites W2007331931 @default.
• W4317874818 cites W2008541396 @default.
• W4317874818 cites W2027001273 @default.
• W4317874818 cites W2062088735 @default.
• W4317874818 cites W2064263860 @default.
• W4317874818 cites W2065622899 @default.
• W4317874818 cites W2067614468 @default.
• W4317874818 cites W2098123297 @default.
• W4317874818 cites W2115770874 @default.
• W4317874818 cites W2145303234 @default.
• W4317874818 cites W2161093233 @default.
• W4317874818 cites W2621309124 @default.
• W4317874818 cites W2742517445 @default.
• W4317874818 cites W2750761716 @default.
• W4317874818 cites W2769286195 @default.
• W4317874818 cites W2802350433 @default.
• W4317874818 cites W2804602549 @default.
• W4317874818 cites W2883294287 @default.
• W4317874818 cites W2886119931 @default.
• W4317874818 cites W2889222072 @default.
• W4317874818 cites W2892224462 @default.
• W4317874818 cites W2914431697 @default.
• W4317874818 cites W2979354278 @default.
• W4317874818 cites W2980616284 @default.
• W4317874818 cites W3017515727 @default.
• W4317874818 cites W3024577693 @default.
• W4317874818 cites W3084415067 @default.
• W4317874818 cites W3097634249 @default.
• W4317874818 cites W3115456245 @default.
• W4317874818 cites W3123566052 @default.
• W4317874818 cites W3155983837 @default.
• W4317874818 cites W3209285056 @default.
• W4317874818 cites W4200035260 @default.
• W4317874818 cites W4214571968 @default.
• W4317874818 cites W4225091444 @default.
• W4317874818 cites W4229017576 @default.
• W4317874818 cites W4280509050 @default.
• W4317874818 cites W4281992806 @default.
• W4317874818 cites W935045094 @default.
• W4317874818 doi "https://doi.org/10.1021/acs.analchem.2c05712" @default.
• W4317874818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36693787" @default.
• W4317874818 hasPublicationYear "2023" @default.
• W4317874818 type Work @default.
• W4317874818 citedByCount "3" @default.
• W4317874818 countsByYear W43178748182023 @default.
• W4317874818 crossrefType "journal-article" @default.
• W4317874818 hasAuthorship W4317874818A5016406818 @default.
• W4317874818 hasAuthorship W4317874818A5017508252 @default.
• W4317874818 hasAuthorship W4317874818A5025615497 @default.
• W4317874818 hasAuthorship W4317874818A5027996570 @default.
• W4317874818 hasAuthorship W4317874818A5031621087 @default.
• W4317874818 hasAuthorship W4317874818A5051897407 @default.
• W4317874818 hasAuthorship W4317874818A5053417739 @default.
• W4317874818 hasAuthorship W4317874818A5055115466 @default.
• W4317874818 hasAuthorship W4317874818A5056391726 @default.
• W4317874818 hasAuthorship W4317874818A5070285898 @default.
• W4317874818 hasAuthorship W4317874818A5073445421 @default.
• W4317874818 hasAuthorship W4317874818A5086419407 @default.
• W4317874818 hasConcept C111919701 @default.
• W4317874818 hasConcept C119128265 @default.
• W4317874818 hasConcept C171250308 @default.
• W4317874818 hasConcept C176553487 @default.
• W4317874818 hasConcept C181199279 @default.
• W4317874818 hasConcept C185592680 @default.
• W4317874818 hasConcept C192562407 @default.
• W4317874818 hasConcept C2776217839 @default.
• W4317874818 hasConcept C2777723881 @default.
• W4317874818 hasConcept C2779489039 @default.
• W4317874818 hasConcept C41008148 @default.
• W4317874818 hasConcept C43617362 @default.
• W4317874818 hasConcept C523546767 @default.
• W4317874818 hasConcept C54355233 @default.
• W4317874818 hasConcept C552990157 @default.
• W4317874818 hasConcept C55493867 @default.
• W4317874818 hasConcept C60635243 @default.
• W4317874818 hasConcept C83762044 @default.
• W4317874818 hasConcept C84211826 @default.

• next