FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317888433> ?p ?o ?g. }

• W4317888433 endingPage "8" @default.
• W4317888433 startingPage "1" @default.
• W4317888433 abstract "Brain Tumour Related Epilepsy (BTRE) has a significant impact on Quality of Life with implications for driving, employment, and social activities. Management of BTRE is complex due to the higher incidence of drug resistance and the potential for interaction between anti-cancer therapy and anti-seizure medications (ASMs). Neurologists, neurosurgeons, oncologists, palliative care physicians and clinical nurse specialists treating these patients would benefit from up-to-date clinical guidelines. We aim to review the current literature and to outline specific recommendations for the optimal treatment of BTRE, encompassing both Primary Brain Tumours (PBT) and Brain Metastases (BM). A comprehensive search of the literature since 1995 on BTRE was carried out in PubMed, MEDLINE and EMCARE. A broad search strategy was used, and the evidence evaluated and graded based on the Oxford Centre for Evidence-Based Medicine Levels of Evidence. Seizure frequency varies between 10 and 40% in patients with Brain Metastases (BM) and from 30% (high-grade gliomas) to 90% (low-grade gliomas) in patients with PBT. In patients with BM, risk factors include number of BM and melanoma histology. In patients with PBT, BTRE is more common in patients with lower grade histology, frontal and temporal tumours, presence of an IDH mutation and cortical infiltration. All patients with BTRE should be treated with ASMs. Non-enzyme inducing ASMs are recommended as first line treatment for BTRE, but up to 50% of patients with BTRE due to PBT remain resistant. There is no proven benefit for the use of prophylactic ASMs, although there are no randomised trials testing newer agents. Surgical and oncological treatments i.e. radiotherapy and chemotherapy improve BTRE. Vagus Nerve Stimulation has been used with partial success. The review highlights the relative dearth of high-quality evidence for the management of BTRE and provides a framework for further studies aiming to improve seizure control, quality of life, and indications for ASMs.KEY POINTSOffer levetiracetam or lamotrigine to all patients with primary or metastatic brain tumours who have seizure(s), irrespective of whether these are partial or generalised.ASM withdrawal for patients in remission is not recommended due to high rates of seizure recurrence.ASM prophylaxis is not generally recommended in the management of seizure-naïve patients.Both levetiracetam and lamotrigine are safe in pregnancy and breastfeeding." @default.
• W4317888433 created "2023-01-25" @default.
• W4317888433 creator A5016587532 @default.
• W4317888433 creator A5024882567 @default.
• W4317888433 creator A5049340335 @default.
• W4317888433 date "2023-01-24" @default.
• W4317888433 modified "2023-10-14" @default.
• W4317888433 title "Management of brain tumour related epilepsy (BTRE): a narrative review and therapy recommendations" @default.
• W4317888433 cites W1511628175 @default.
• W4317888433 cites W1516943082 @default.
• W4317888433 cites W1529528230 @default.
• W4317888433 cites W1534724830 @default.
• W4317888433 cites W1569307548 @default.
• W4317888433 cites W1847229489 @default.
• W4317888433 cites W1903052549 @default.
• W4317888433 cites W1919534843 @default.
• W4317888433 cites W1941054595 @default.
• W4317888433 cites W1964316135 @default.
• W4317888433 cites W1971188893 @default.
• W4317888433 cites W1981182173 @default.
• W4317888433 cites W1988485450 @default.
• W4317888433 cites W1990638963 @default.
• W4317888433 cites W2000061615 @default.
• W4317888433 cites W2005501262 @default.
• W4317888433 cites W2006139919 @default.
• W4317888433 cites W2011696259 @default.
• W4317888433 cites W2021657776 @default.
• W4317888433 cites W2044931150 @default.
• W4317888433 cites W2047168413 @default.
• W4317888433 cites W2063957584 @default.
• W4317888433 cites W2069634141 @default.
• W4317888433 cites W2084102376 @default.
• W4317888433 cites W2087253414 @default.
• W4317888433 cites W2091956563 @default.
• W4317888433 cites W2105420171 @default.
• W4317888433 cites W2111042597 @default.
• W4317888433 cites W2113888256 @default.
• W4317888433 cites W2119838967 @default.
• W4317888433 cites W2125360780 @default.
• W4317888433 cites W2138521331 @default.
• W4317888433 cites W2142707663 @default.
• W4317888433 cites W2154375103 @default.
• W4317888433 cites W2158031796 @default.
• W4317888433 cites W2159458030 @default.
• W4317888433 cites W2163642916 @default.
• W4317888433 cites W2169605702 @default.
• W4317888433 cites W2256711934 @default.
• W4317888433 cites W2300261369 @default.
• W4317888433 cites W2500516809 @default.
• W4317888433 cites W2553382755 @default.
• W4317888433 cites W2567682931 @default.
• W4317888433 cites W2605860968 @default.
• W4317888433 cites W2613043745 @default.
• W4317888433 cites W2619520323 @default.
• W4317888433 cites W2900426049 @default.
• W4317888433 cites W2902908206 @default.
• W4317888433 cites W2915033240 @default.
• W4317888433 cites W2917627226 @default.
• W4317888433 cites W2921879040 @default.
• W4317888433 cites W2972859642 @default.
• W4317888433 cites W3017843016 @default.
• W4317888433 cites W3021725458 @default.
• W4317888433 cites W3038246222 @default.
• W4317888433 cites W3091996554 @default.
• W4317888433 cites W3119770655 @default.
• W4317888433 cites W3136371530 @default.
• W4317888433 cites W3167079868 @default.
• W4317888433 cites W4283271160 @default.
• W4317888433 doi "https://doi.org/10.1080/02688697.2023.2170326" @default.
• W4317888433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36694327" @default.
• W4317888433 hasPublicationYear "2023" @default.
• W4317888433 type Work @default.
• W4317888433 citedByCount "0" @default.
• W4317888433 crossrefType "journal-article" @default.
• W4317888433 hasAuthorship W4317888433A5016587532 @default.
• W4317888433 hasAuthorship W4317888433A5024882567 @default.
• W4317888433 hasAuthorship W4317888433A5049340335 @default.
• W4317888433 hasConcept C118552586 @default.
• W4317888433 hasConcept C126322002 @default.
• W4317888433 hasConcept C142724271 @default.
• W4317888433 hasConcept C159110408 @default.
• W4317888433 hasConcept C17744445 @default.
• W4317888433 hasConcept C177713679 @default.
• W4317888433 hasConcept C199539241 @default.
• W4317888433 hasConcept C2778186239 @default.
• W4317888433 hasConcept C2778227246 @default.
• W4317888433 hasConcept C2779130545 @default.
• W4317888433 hasConcept C2779473830 @default.
• W4317888433 hasConcept C2779951463 @default.
• W4317888433 hasConcept C2994186709 @default.
• W4317888433 hasConcept C3020000205 @default.
• W4317888433 hasConcept C502942594 @default.
• W4317888433 hasConcept C71924100 @default.
• W4317888433 hasConceptScore W4317888433C118552586 @default.
• W4317888433 hasConceptScore W4317888433C126322002 @default.
• W4317888433 hasConceptScore W4317888433C142724271 @default.
• W4317888433 hasConceptScore W4317888433C159110408 @default.
• W4317888433 hasConceptScore W4317888433C17744445 @default.

• next