FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317889275> ?p ?o ?g. }

• W4317889275 abstract "Abstract Malaria is a mosquito-borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes. Here we study how Culex pipiens mosquitoes transcriptionally respond to infection by two different Plasmodium species, P. relictum and P. cathemerium , differing in their virulence (mortality rate) and transmissibility (parasite presence in exposed mosquitoes’ saliva). We study the mosquito response to the infection at three critical stages of parasite development: formation of ookinetes at 24 hours post-infection (hpi), the release of sporozoites into the hemocoel at 10 days post-infection (dpi), and storage of sporozoites in the salivary glands at 21dpi. For each time point, we characterized the gene expression of mosquitoes infected with each P. relictum and P. cathemerium and mosquitoes fed on an uninfected bird and, subsequently, compared their transcriptomic responses. Differential gene expression analysis showed most of the transcriptomic changes occurred during the early infection stage (24 hpi), especially when comparing P. relictum and P. cathemerium infected mosquitoes. Differentially expressed genes in mosquitoes infected with each species were related mainly to the immune response, trypsin, and other serine-proteases metabolism. We conclude that these differences in response may partly play a role in the differential virulence and transmissibility previously observed in P. relictum and P. cathemerium in Cx. pipiens ." @default.
• W4317889275 created "2023-01-25" @default.
• W4317889275 creator A5013306504 @default.
• W4317889275 creator A5015728709 @default.
• W4317889275 creator A5040713228 @default.
• W4317889275 creator A5052750731 @default.
• W4317889275 creator A5063469614 @default.
• W4317889275 date "2023-01-24" @default.
• W4317889275 modified "2023-10-18" @default.
• W4317889275 title "Two avian<i>Plasmodium</i>species trigger different transcriptional responses on their vector<i>Culex pipiens</i>" @default.
• W4317889275 cites W133779161 @default.
• W4317889275 cites W1521150511 @default.
• W4317889275 cites W1552845950 @default.
• W4317889275 cites W1754711307 @default.
• W4317889275 cites W1771142266 @default.
• W4317889275 cites W1908521937 @default.
• W4317889275 cites W1963097328 @default.
• W4317889275 cites W1965517564 @default.
• W4317889275 cites W1971395880 @default.
• W4317889275 cites W1973094248 @default.
• W4317889275 cites W1982362155 @default.
• W4317889275 cites W1983842527 @default.
• W4317889275 cites W1985418757 @default.
• W4317889275 cites W1985977889 @default.
• W4317889275 cites W1987053612 @default.
• W4317889275 cites W1994055913 @default.
• W4317889275 cites W1994464155 @default.
• W4317889275 cites W2016693012 @default.
• W4317889275 cites W2019211309 @default.
• W4317889275 cites W2021849213 @default.
• W4317889275 cites W2027928475 @default.
• W4317889275 cites W2034937344 @default.
• W4317889275 cites W2038076327 @default.
• W4317889275 cites W2038344983 @default.
• W4317889275 cites W2039865491 @default.
• W4317889275 cites W2040466051 @default.
• W4317889275 cites W2042958174 @default.
• W4317889275 cites W2046085573 @default.
• W4317889275 cites W2048404510 @default.
• W4317889275 cites W2048663311 @default.
• W4317889275 cites W2053551770 @default.
• W4317889275 cites W2065195037 @default.
• W4317889275 cites W2072372372 @default.
• W4317889275 cites W2087694981 @default.
• W4317889275 cites W2090445407 @default.
• W4317889275 cites W2099150804 @default.
• W4317889275 cites W2101018280 @default.
• W4317889275 cites W2110642130 @default.
• W4317889275 cites W2112577424 @default.
• W4317889275 cites W2120309219 @default.
• W4317889275 cites W2128880918 @default.
• W4317889275 cites W2131271579 @default.
• W4317889275 cites W2134306544 @default.
• W4317889275 cites W2136599658 @default.
• W4317889275 cites W2141150896 @default.
• W4317889275 cites W2146992824 @default.
• W4317889275 cites W2151716542 @default.
• W4317889275 cites W2155111869 @default.
• W4317889275 cites W2158091936 @default.
• W4317889275 cites W2169456326 @default.
• W4317889275 cites W2172951629 @default.
• W4317889275 cites W2198497392 @default.
• W4317889275 cites W2432815617 @default.
• W4317889275 cites W2751963693 @default.
• W4317889275 cites W2783738234 @default.
• W4317889275 cites W2801658401 @default.
• W4317889275 cites W2808764764 @default.
• W4317889275 cites W2887568208 @default.
• W4317889275 cites W2917576966 @default.
• W4317889275 cites W2949473228 @default.
• W4317889275 cites W2951818637 @default.
• W4317889275 cites W2991266001 @default.
• W4317889275 cites W3001602243 @default.
• W4317889275 cites W3013805467 @default.
• W4317889275 cites W3019110708 @default.
• W4317889275 cites W3133577145 @default.
• W4317889275 cites W3142047741 @default.
• W4317889275 cites W3213609746 @default.
• W4317889275 cites W421839203 @default.
• W4317889275 cites W4254687493 @default.
• W4317889275 cites W4283013760 @default.
• W4317889275 cites W4293434831 @default.
• W4317889275 cites W595058896 @default.
• W4317889275 cites W758087015 @default.
• W4317889275 doi "https://doi.org/10.1101/2023.01.24.525339" @default.
• W4317889275 hasPublicationYear "2023" @default.
• W4317889275 type Work @default.
• W4317889275 citedByCount "0" @default.
• W4317889275 crossrefType "posted-content" @default.
• W4317889275 hasAuthorship W4317889275A5013306504 @default.
• W4317889275 hasAuthorship W4317889275A5015728709 @default.
• W4317889275 hasAuthorship W4317889275A5040713228 @default.
• W4317889275 hasAuthorship W4317889275A5052750731 @default.
• W4317889275 hasAuthorship W4317889275A5063469614 @default.
• W4317889275 hasBestOaLocation W43178892751 @default.
• W4317889275 hasConcept C104317684 @default.
• W4317889275 hasConcept C136764020 @default.
• W4317889275 hasConcept C150194340 @default.
• W4317889275 hasConcept C159047783 @default.
• W4317889275 hasConcept C162317418 @default.

• next