FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317929652> ?p ?o ?g. }

• W4317929652 endingPage "7360" @default.
• W4317929652 startingPage "7351" @default.
• W4317929652 abstract "Autocrine trophic functions of brain-derived neurotrophic factor (BDNF) have been proposed for many central neurons because this neurotrophin displays striking colocalization with its receptor trkB within the CNS. In the cortex, the distribution patterns of BDNF and trkB expression are almost identical. Corticospinal neurons (CSNs) are a major cortical long-distance projecting system. They are localized in layer V of the somatosensory cortex, and their axons project into the spinal cord where they contribute to the innervation of spinal motoneurons. We have shown recently that adult CSNs express trkB mRNA and are rescued from axotomy-induced death by BDNF treatment. Half of the axotomized CSNs survived without BDNF infusions. These findings raise the possibility that endogenous cortical BDNF is involved in the trophic support of this neuronal population. To test the hypothesis that endogenous cortical BDNF promotes survival of adult CSNs, we infused the BDNF-neutralizing affinity-purified antibody RAB to axotomized and unlesioned CSNs for 7 d. This treatment resulted in increased death of axotomized CSNs. Survival of unlesioned CSNs was not affected by RAB treatment. In situ hybridizations for BDNF and trkB mRNA revealed that virtually all CSNs express trkB, whereas only half of them express BDNF. Thus, autocrine/paracrine mechanisms are likely to contribute to the endogenous BDNF protection of axotomized CSNs. We have demonstrated previously that, in addition to BDNF, glial cell line-derived neurotrophic factor (GDNF) and neurotrophin 3 (NT-3) also rescue CSNs from axotomy-induced death. We now show that the rescuing by GDNF requires the presence of endogenous cortical BDNF, implicating a central role of this neurotrophin in the trophic support of axotomized CSNs and a trophic cross-talk between BDNF and GDNF regarding the maintenance of lesioned CSNs. In contrast, NT-3 promotes survival of axotomized CSNs even when endogenous cortical BDNF is neutralized by RAB, indicating a potential of compensatory mechanisms for the trophic support of CSNs." @default.
• W4317929652 created "2023-01-25" @default.
• W4317929652 creator A5004942312 @default.
• W4317929652 creator A5048630664 @default.
• W4317929652 creator A5075633380 @default.
• W4317929652 creator A5080251597 @default.
• W4317929652 date "1998-09-15" @default.
• W4317929652 modified "2023-10-13" @default.
• W4317929652 title "The Survival-Promoting Effect of Glial Cell Line-Derived Neurotrophic Factor on Axotomized Corticospinal Neurons<i>In Vivo</i>Is Mediated by an Endogenous Brain-Derived Neurotrophic Factor Mechanism" @default.
• W4317929652 cites W127771585 @default.
• W4317929652 cites W1527229950 @default.
• W4317929652 cites W1607238413 @default.
• W4317929652 cites W1664741673 @default.
• W4317929652 cites W1892553999 @default.
• W4317929652 cites W1966019489 @default.
• W4317929652 cites W1966734514 @default.
• W4317929652 cites W1971644755 @default.
• W4317929652 cites W1974572588 @default.
• W4317929652 cites W1976857475 @default.
• W4317929652 cites W1981238340 @default.
• W4317929652 cites W1983777466 @default.
• W4317929652 cites W1986662264 @default.
• W4317929652 cites W1991206010 @default.
• W4317929652 cites W1992230509 @default.
• W4317929652 cites W1992559858 @default.
• W4317929652 cites W1997420582 @default.
• W4317929652 cites W2000304313 @default.
• W4317929652 cites W2000540402 @default.
• W4317929652 cites W2011663144 @default.
• W4317929652 cites W2012246166 @default.
• W4317929652 cites W2014078232 @default.
• W4317929652 cites W2018068734 @default.
• W4317929652 cites W2019864299 @default.
• W4317929652 cites W2020333978 @default.
• W4317929652 cites W2021453246 @default.
• W4317929652 cites W2026904817 @default.
• W4317929652 cites W2027322371 @default.
• W4317929652 cites W2027443989 @default.
• W4317929652 cites W2028093783 @default.
• W4317929652 cites W2030204732 @default.
• W4317929652 cites W2030848480 @default.
• W4317929652 cites W2033333756 @default.
• W4317929652 cites W2036645192 @default.
• W4317929652 cites W2037877262 @default.
• W4317929652 cites W2038563688 @default.
• W4317929652 cites W2040138609 @default.
• W4317929652 cites W2049099403 @default.
• W4317929652 cites W2051600135 @default.
• W4317929652 cites W2054810445 @default.
• W4317929652 cites W2055149392 @default.
• W4317929652 cites W206110463 @default.
• W4317929652 cites W2061919885 @default.
• W4317929652 cites W2063728359 @default.
• W4317929652 cites W2066342229 @default.
• W4317929652 cites W2067243932 @default.
• W4317929652 cites W2068118161 @default.
• W4317929652 cites W2069527370 @default.
• W4317929652 cites W2072626617 @default.
• W4317929652 cites W2073738066 @default.
• W4317929652 cites W2076894554 @default.
• W4317929652 cites W2082584428 @default.
• W4317929652 cites W2085567491 @default.
• W4317929652 cites W2089309198 @default.
• W4317929652 cites W2091316910 @default.
• W4317929652 cites W2093091814 @default.
• W4317929652 cites W2093283972 @default.
• W4317929652 cites W2100422274 @default.
• W4317929652 cites W2100487936 @default.
• W4317929652 cites W2101433654 @default.
• W4317929652 cites W2110795584 @default.
• W4317929652 cites W2117830068 @default.
• W4317929652 cites W2121692338 @default.
• W4317929652 cites W2125403403 @default.
• W4317929652 cites W2126706634 @default.
• W4317929652 cites W2142746886 @default.
• W4317929652 cites W2146540279 @default.
• W4317929652 cites W2155008473 @default.
• W4317929652 cites W2155907187 @default.
• W4317929652 cites W2159031404 @default.
• W4317929652 cites W2163430558 @default.
• W4317929652 cites W2165836217 @default.
• W4317929652 cites W2173351113 @default.
• W4317929652 cites W345353101 @default.
• W4317929652 cites W907510603 @default.
• W4317929652 doi "https://doi.org/10.1523/jneurosci.18-18-07351.1998" @default.
• W4317929652 hasPublicationYear "1998" @default.
• W4317929652 type Work @default.
• W4317929652 citedByCount "75" @default.
• W4317929652 countsByYear W43179296522012 @default.
• W4317929652 countsByYear W43179296522013 @default.
• W4317929652 countsByYear W43179296522014 @default.
• W4317929652 countsByYear W43179296522015 @default.
• W4317929652 countsByYear W43179296522016 @default.
• W4317929652 countsByYear W43179296522017 @default.
• W4317929652 countsByYear W43179296522019 @default.
• W4317929652 countsByYear W43179296522023 @default.
• W4317929652 crossrefType "journal-article" @default.
• W4317929652 hasAuthorship W4317929652A5004942312 @default.

• next