Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317929906> ?p ?o ?g. }
- W4317929906 endingPage "113490" @default.
- W4317929906 startingPage "113490" @default.
- W4317929906 abstract "Thymocyte antigen-1 (THY-1)is a potential target for rheumatoid arthritis (RA) treatment, and THY-1 positive fibroblast-like synoviocytes (FLS) are enriched in the synovium of RA patients and participate in angiogenesis to accelerate RA progression. In this study, we screened an antibody targeting THY-1 (THY-1 Ab) and explored its mechanism in alleviating RA progression. THY-1 Ab was screened from ScFv phage antibody library by phage display technology (PDT). THY-1 Ab-treated collagen induced arthritis (CIA) mice had lower degree of arthritis scores. We explore the mechanism of THY-1 Ab in alleviating RA progression. THY-1 Ab can remarkably inhibit the secretion of pro-inflammatory factors and promote the secretion of anti-inflammatory factors. Further experiments showed that THY1 Ab downregulated the expression of JUNB by the hsa_circ_0094342/miRNA-155-5P/SPI1 axis, inhibited RA angiogenesis and osteoclast differentiation, and relieved RA progression. These findings support that THY-1 Ab is a promising therapeutic antibody for RA treatment." @default.
- W4317929906 created "2023-01-25" @default.
- W4317929906 creator A5007316047 @default.
- W4317929906 creator A5007713753 @default.
- W4317929906 creator A5011740024 @default.
- W4317929906 creator A5014306354 @default.
- W4317929906 creator A5033428348 @default.
- W4317929906 creator A5041914778 @default.
- W4317929906 creator A5043970512 @default.
- W4317929906 creator A5045604568 @default.
- W4317929906 creator A5053868737 @default.
- W4317929906 creator A5062336405 @default.
- W4317929906 creator A5067550974 @default.
- W4317929906 creator A5071773009 @default.
- W4317929906 creator A5078154497 @default.
- W4317929906 creator A5080862022 @default.
- W4317929906 creator A5090815103 @default.
- W4317929906 date "2023-03-01" @default.
- W4317929906 modified "2023-10-01" @default.
- W4317929906 title "An innovative immunotherapeutic strategy for rheumatoid arthritis: Selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1" @default.
- W4317929906 cites W1487922621 @default.
- W4317929906 cites W1614065776 @default.
- W4317929906 cites W1965502287 @default.
- W4317929906 cites W1999274686 @default.
- W4317929906 cites W2000141520 @default.
- W4317929906 cites W2000468514 @default.
- W4317929906 cites W2016261626 @default.
- W4317929906 cites W2049909893 @default.
- W4317929906 cites W2078472807 @default.
- W4317929906 cites W2092472660 @default.
- W4317929906 cites W2110826367 @default.
- W4317929906 cites W2142004396 @default.
- W4317929906 cites W2166237193 @default.
- W4317929906 cites W2170556348 @default.
- W4317929906 cites W2171628252 @default.
- W4317929906 cites W2405805977 @default.
- W4317929906 cites W2533866764 @default.
- W4317929906 cites W2564659835 @default.
- W4317929906 cites W2622000437 @default.
- W4317929906 cites W2624671969 @default.
- W4317929906 cites W2895590824 @default.
- W4317929906 cites W2944564829 @default.
- W4317929906 cites W2947027538 @default.
- W4317929906 cites W3018856393 @default.
- W4317929906 cites W3022414345 @default.
- W4317929906 cites W3039396378 @default.
- W4317929906 cites W3044690826 @default.
- W4317929906 cites W3170306341 @default.
- W4317929906 cites W3186135580 @default.
- W4317929906 cites W3214799576 @default.
- W4317929906 cites W4210529991 @default.
- W4317929906 cites W4239943677 @default.
- W4317929906 doi "https://doi.org/10.1016/j.yexcr.2023.113490" @default.
- W4317929906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36706943" @default.
- W4317929906 hasPublicationYear "2023" @default.
- W4317929906 type Work @default.
- W4317929906 citedByCount "2" @default.
- W4317929906 countsByYear W43179299062023 @default.
- W4317929906 crossrefType "journal-article" @default.
- W4317929906 hasAuthorship W4317929906A5007316047 @default.
- W4317929906 hasAuthorship W4317929906A5007713753 @default.
- W4317929906 hasAuthorship W4317929906A5011740024 @default.
- W4317929906 hasAuthorship W4317929906A5014306354 @default.
- W4317929906 hasAuthorship W4317929906A5033428348 @default.
- W4317929906 hasAuthorship W4317929906A5041914778 @default.
- W4317929906 hasAuthorship W4317929906A5043970512 @default.
- W4317929906 hasAuthorship W4317929906A5045604568 @default.
- W4317929906 hasAuthorship W4317929906A5053868737 @default.
- W4317929906 hasAuthorship W4317929906A5062336405 @default.
- W4317929906 hasAuthorship W4317929906A5067550974 @default.
- W4317929906 hasAuthorship W4317929906A5071773009 @default.
- W4317929906 hasAuthorship W4317929906A5078154497 @default.
- W4317929906 hasAuthorship W4317929906A5080862022 @default.
- W4317929906 hasAuthorship W4317929906A5090815103 @default.
- W4317929906 hasBestOaLocation W43179299061 @default.
- W4317929906 hasConcept C134018914 @default.
- W4317929906 hasConcept C147483822 @default.
- W4317929906 hasConcept C159654299 @default.
- W4317929906 hasConcept C170493617 @default.
- W4317929906 hasConcept C203014093 @default.
- W4317929906 hasConcept C2776033226 @default.
- W4317929906 hasConcept C2777077863 @default.
- W4317929906 hasConcept C2777575956 @default.
- W4317929906 hasConcept C2780394083 @default.
- W4317929906 hasConcept C49039625 @default.
- W4317929906 hasConcept C502942594 @default.
- W4317929906 hasConcept C55493867 @default.
- W4317929906 hasConcept C86803240 @default.
- W4317929906 hasConceptScore W4317929906C134018914 @default.
- W4317929906 hasConceptScore W4317929906C147483822 @default.
- W4317929906 hasConceptScore W4317929906C159654299 @default.
- W4317929906 hasConceptScore W4317929906C170493617 @default.
- W4317929906 hasConceptScore W4317929906C203014093 @default.
- W4317929906 hasConceptScore W4317929906C2776033226 @default.
- W4317929906 hasConceptScore W4317929906C2777077863 @default.
- W4317929906 hasConceptScore W4317929906C2777575956 @default.
- W4317929906 hasConceptScore W4317929906C2780394083 @default.
- W4317929906 hasConceptScore W4317929906C49039625 @default.