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• W4317931728 endingPage "104644" @default.
• W4317931728 startingPage "104644" @default.
• W4317931728 abstract "Many amphibian populations are declining worldwide, and infectious diseases are a leading cause. Given the eminent threat infectious diseases pose to amphibian populations, there is a need to understand the host-pathogen-environment interactions that govern amphibian susceptibility to disease and mortality events. However, using animals in research raises an ethical dilemma, which is magnified by the alarming rates at which many amphibian populations are declining. Thus, in vitro study systems such as cell lines represent valuable tools for furthering our understanding of amphibian immune systems. In this review, we curate a list of the amphibian cell lines established to date (the amphibian invitrome), highlight how research using amphibian cell lines has advanced our understanding of the amphibian immune system, anti-ranaviral defence mechanisms, and Batrachochytrium dendrobatidis replication in host cells, and offer our perspective on how future use of amphibian cell lines can advance the field of amphibian immunology." @default.
• W4317931728 created "2023-01-25" @default.
• W4317931728 creator A5004242477 @default.
• W4317931728 creator A5052329878 @default.
• W4317931728 creator A5087147078 @default.
• W4317931728 date "2023-05-01" @default.
• W4317931728 modified "2023-09-26" @default.
• W4317931728 title "The amphibian invitrome: Past, present, and future contributions to our understanding of amphibian immunity" @default.
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