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• W4317932204 endingPage "713" @default.
• W4317932204 startingPage "713" @default.
• W4317932204 abstract "Anti-cancer antibody-drug conjugates (ADCs) aim to expand the therapeutic index of traditional chemotherapy by employing the targeting specificity of monoclonal antibodies (mAbs) to increase the efficiency of the delivery of potent cytotoxic agents to malignant cells. In the past three years, the number of ADCs approved by the Food and Drug Administration (FDA) has tripled. Although several ADCs have demonstrated sufficient efficacy and safety to warrant FDA approval, the clinical use of all ADCs leads to substantial toxicity in treated patients, and many ADCs have failed during clinical development due to their unacceptable toxicity profiles. Analysis of the clinical data has demonstrated that dose-limiting toxicities (DLTs) are often shared by different ADCs that deliver the same cytotoxic payload, independent of the antigen that is targeted and/or the type of cancer that is treated. DLTs are commonly associated with cells and tissues that do not express the targeted antigen (i.e., off-target toxicity), and often limit ADC dosage to levels below those required for optimal anti-cancer effects. In this manuscript, we review the fundamental mechanisms contributing to ADC toxicity, we summarize common ADC treatment-related adverse events, and we discuss several approaches to mitigating ADC toxicity." @default.
• W4317932204 created "2023-01-25" @default.
• W4317932204 creator A5006940157 @default.
• W4317932204 creator A5045163049 @default.
• W4317932204 creator A5080914054 @default.
• W4317932204 date "2023-01-24" @default.
• W4317932204 modified "2023-09-30" @default.
• W4317932204 title "Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability" @default.
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