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• W4317937652 abstract "Presynaptic inputs determine the pattern of activation of postsynaptic neurons in a neural circuit. Molecular and genetic pathways that regulate the selective formation of subsets of presynaptic inputs are largely unknown, despite significant understanding of the general process of synaptogenesis. In this study, we have begun to identify such factors using the spinal monosynaptic stretch reflex circuit as a model system. In this neuronal circuit, Ia proprioceptive afferents establish monosynaptic connections with spinal motor neurons that project to the same muscle (termed homonymous connections) or muscles with related or synergistic function. However, monosynaptic connections are not formed with motor neurons innervating muscles with antagonistic functions. The ETS transcription factor ER81 (also known as ETV1) is expressed by all proprioceptive afferents, but only a small set of motor neuron pools in the lumbar spinal cord of the mouse. Here we use conditional mouse genetic techniques to eliminate Er81 expression selectively from motor neurons. We find that ablation of Er81 in motor neurons reduces synaptic inputs from proprioceptive afferents conveying information from homonymous and synergistic muscles, with no change observed in the connectivity pattern from antagonistic proprioceptive afferents. In summary, these findings suggest a role for ER81 in defined motor neuron pools to control the assembly of specific presynaptic inputs and thereby influence the profile of activation of these motor neurons." @default.
• W4317937652 created "2023-01-25" @default.
• W4317937652 creator A5058094660 @default.
• W4317937652 creator A5080499335 @default.
• W4317937652 date "2023-03-01" @default.
• W4317937652 modified "2023-10-18" @default.
• W4317937652 title "Loss of ETV1/ER81 in motor neurons leads to reduced monosynaptic inputs from proprioceptive sensory neurons" @default.
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• W4317937652 doi "https://doi.org/10.1152/jn.00172.2022" @default.
• W4317937652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36695533" @default.
• W4317937652 hasPublicationYear "2023" @default.
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