FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317951785> ?p ?o ?g. }

• W4317951785 abstract "The assembly state of enzymes is gaining interest as a mechanism for regulating the function of enzymes in living cells. One of the current topics in enzymology is the relationship between enzyme activity and the assembly state due to liquid-liquid phase separation. In this study, we demonstrated enzyme activation via the formation of enzyme assemblies using L-lactate oxidase (LOX). LOX formed hundreds of nanometer-scale assemblies with poly-L-lysine (PLL). In the presence of ammonium sulfate, the LOX-PLL clusters formed micrometer-scale liquid droplets. The enzyme activities of LOX in clusters and droplets were one order of magnitude higher than those in the dispersed state, owing to a decrease in KM and an increase in kcat. Moreover, the clusters exhibited a higher activation effect than the droplets. In addition, the conformation of LOX changed in the clusters, resulting in increased enzyme activation. Understanding enzyme activation and assembly states provides important information regarding enzyme function in living cells, in addition to biotechnology applications." @default.
• W4317951785 created "2023-01-25" @default.
• W4317951785 creator A5048974482 @default.
• W4317951785 creator A5051518048 @default.
• W4317951785 creator A5053890551 @default.
• W4317951785 creator A5067888768 @default.
• W4317951785 creator A5068713356 @default.
• W4317951785 creator A5072643183 @default.
• W4317951785 creator A5075655482 @default.
• W4317951785 creator A5082892300 @default.
• W4317951785 date "2023-01-25" @default.
• W4317951785 modified "2023-10-09" @default.
• W4317951785 title "Activation of L-lactate oxidase by the formation of enzyme assemblies through liquid–liquid phase separation" @default.
• W4317951785 cites W1765292380 @default.
• W4317951785 cites W187801720 @default.
• W4317951785 cites W1941479381 @default.
• W4317951785 cites W1965592125 @default.
• W4317951785 cites W1980248898 @default.
• W4317951785 cites W1980766416 @default.
• W4317951785 cites W1981428798 @default.
• W4317951785 cites W2009994916 @default.
• W4317951785 cites W2026826346 @default.
• W4317951785 cites W2065551556 @default.
• W4317951785 cites W2066736364 @default.
• W4317951785 cites W2075812604 @default.
• W4317951785 cites W2079905392 @default.
• W4317951785 cites W2105311961 @default.
• W4317951785 cites W2138595670 @default.
• W4317951785 cites W2139170605 @default.
• W4317951785 cites W2157607146 @default.
• W4317951785 cites W2165581033 @default.
• W4317951785 cites W2168639701 @default.
• W4317951785 cites W2182726182 @default.
• W4317951785 cites W2325242266 @default.
• W4317951785 cites W2428068016 @default.
• W4317951785 cites W2553996574 @default.
• W4317951785 cites W2590568317 @default.
• W4317951785 cites W2623049174 @default.
• W4317951785 cites W2738634672 @default.
• W4317951785 cites W2747767866 @default.
• W4317951785 cites W2755105920 @default.
• W4317951785 cites W2756821926 @default.
• W4317951785 cites W2765094271 @default.
• W4317951785 cites W2885161568 @default.
• W4317951785 cites W2894833434 @default.
• W4317951785 cites W2905568751 @default.
• W4317951785 cites W2925734201 @default.
• W4317951785 cites W2956314154 @default.
• W4317951785 cites W3030949439 @default.
• W4317951785 cites W3087691776 @default.
• W4317951785 cites W3093315678 @default.
• W4317951785 cites W3094499969 @default.
• W4317951785 cites W3138914839 @default.
• W4317951785 cites W3139160981 @default.
• W4317951785 cites W3157289660 @default.
• W4317951785 cites W3164397064 @default.
• W4317951785 cites W3171646609 @default.
• W4317951785 cites W3204934845 @default.
• W4317951785 cites W3212646764 @default.
• W4317951785 cites W4283014865 @default.
• W4317951785 cites W4296960873 @default.
• W4317951785 doi "https://doi.org/10.1038/s41598-023-28040-1" @default.
• W4317951785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36697449" @default.
• W4317951785 hasPublicationYear "2023" @default.
• W4317951785 type Work @default.
• W4317951785 citedByCount "2" @default.
• W4317951785 countsByYear W43179517852023 @default.
• W4317951785 crossrefType "journal-article" @default.
• W4317951785 hasAuthorship W4317951785A5048974482 @default.
• W4317951785 hasAuthorship W4317951785A5051518048 @default.
• W4317951785 hasAuthorship W4317951785A5053890551 @default.
• W4317951785 hasAuthorship W4317951785A5067888768 @default.
• W4317951785 hasAuthorship W4317951785A5068713356 @default.
• W4317951785 hasAuthorship W4317951785A5072643183 @default.
• W4317951785 hasAuthorship W4317951785A5075655482 @default.
• W4317951785 hasAuthorship W4317951785A5082892300 @default.
• W4317951785 hasBestOaLocation W43179517851 @default.
• W4317951785 hasConcept C125209161 @default.
• W4317951785 hasConcept C12554922 @default.
• W4317951785 hasConcept C14036430 @default.
• W4317951785 hasConcept C178790620 @default.
• W4317951785 hasConcept C181199279 @default.
• W4317951785 hasConcept C185592680 @default.
• W4317951785 hasConcept C2780925461 @default.
• W4317951785 hasConcept C28212737 @default.
• W4317951785 hasConcept C41183919 @default.
• W4317951785 hasConcept C43617362 @default.
• W4317951785 hasConcept C44280652 @default.
• W4317951785 hasConcept C55493867 @default.
• W4317951785 hasConcept C56856141 @default.
• W4317951785 hasConcept C86803240 @default.
• W4317951785 hasConcept C95444343 @default.
• W4317951785 hasConceptScore W4317951785C125209161 @default.
• W4317951785 hasConceptScore W4317951785C12554922 @default.
• W4317951785 hasConceptScore W4317951785C14036430 @default.
• W4317951785 hasConceptScore W4317951785C178790620 @default.
• W4317951785 hasConceptScore W4317951785C181199279 @default.
• W4317951785 hasConceptScore W4317951785C185592680 @default.
• W4317951785 hasConceptScore W4317951785C2780925461 @default.
• W4317951785 hasConceptScore W4317951785C28212737 @default.

• next