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- W4317998975 abstract "Type I interferons (IFN) are widely expressed cytokines that play a pivotal role in the cell-intrinsic antimicrobial process, especially in viral infections. Studies have shown an increased expression of Type I IFNs and their induced genes in peripheral blood cells and exocrine glands from patients with Sjögren’s syndrome (SS), indicating that the Type I IFN pathway a vital role in the pathogenesis of this disease. The source of upregulated Type I IFNs in patients with SS is unknown. Many cells were reported to contribute to the process, especially plasmacytoid dendritic cells and other innate immune cells. The activation of Type I IFN signalling was regulated by both genetic and epigenetic pathways, suggesting that genetic predisposition and environmental factors may affect the initiation and progression of SS. Treatments targeting the Type I IFN pathway are still under evaluation and more results are needed to see their value. The authors’ review aims to summarise the functions and regulations of Type I IFNs in the pathogenesis of SS. They also summarise current treatments (including clinical trials) targeting the Type I IFN pathway in treating SS and provide potential targets for future studies." @default.
- W4317998975 created "2023-01-26" @default.
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- W4317998975 date "2022-07-14" @default.
- W4317998975 modified "2023-10-01" @default.
- W4317998975 title "Type I Interferons in the Pathogenesis and Treatment of Sjögren’s Syndrome: An Update" @default.
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- W4317998975 doi "https://doi.org/10.33590/emjrheumatol/22-00077" @default.
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