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- W4318022969 abstract "The brain is an ultra-soft viscoelastic matrix. Sub-kPa hydrogels match the brain's mechanical properties but are challenging to manipulate in an implantable format. We propose a simple fabrication and processing sequence, consisting of de-hydration, patterning, implantation, and re-hydration steps, to deliver brain-like hydrogel implants into the nervous tissue. We monitored in real-time the ultra-soft hydrogel re-swelling kinetics in vivo using microcomputed tomography, achieved by embedding gold nanoparticles inside the hydrogel for contrast enhancement. We found that re-swelling in vivo strongly depends on the implant geometry and water availability at the hydrogel-tissue interface. Buckling of the implant inside the brain occurs when the soft implant is tethered to the cranium. Finite-element and analytical models reveal how the shank geometry, modulus and anchoring govern in vivo buckling. Taken together, these considerations on re-swelling kinetics of hydrogel constructs, implant geometry and soft implant-tissue mechanical interplay can guide the engineering of biomimetic brain implants." @default.
- W4318022969 created "2023-01-26" @default.
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- W4318022969 date "2023-03-01" @default.
- W4318022969 modified "2023-10-02" @default.
- W4318022969 title "Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain" @default.
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- W4318022969 doi "https://doi.org/10.1016/j.biomaterials.2023.122024" @default.
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