FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318025815> ?p ?o ?g. }

• W4318025815 abstract "Uruguay has one of the highest per capita milk intakes worldwide, even with a limited supply of lactose-free products; furthermore, the admixed nature of its population is well known, and various frequencies of lactase persistence (LP) are observed in the source populations. We aimed to contribute to the understanding of the relation between allelic variants associated with LP, milk consumption, digestive symptoms, and genetic ancestry in the Uruguayan population. Samples of saliva or peripheral blood were collected from 190 unrelated individuals from two regions of Uruguay, genotypes for polymorphic sites in a fragment within the LCT enhancer were determined and allelic frequencies calculated in all of them. Data were collected on frequency of milk and dairy consumption and self-reported symptoms in a subsample of 153 individuals. Biparental and maternal ancestry was determined by analyzing individual ancestry markers and mitochondrial DNA. Twenty-nine percentage of individuals reported symptoms attributed to the ingestion of fresh milk, with abdominal pain, bloating and flatulence being the most frequent. European LP-associated allele T-13910 showed a frequency of 33%, while other LP-associated alleles like G-13915 and T-14011 were observed in very low frequencies. Associations between self-reported symptoms, fresh milk intake, and C/T-13910 genotype were statistically significant. No evidence of association between genetic ancestry and C/T-13910 was found, although individuals carrying one T-13910 allele appeared to have more European ancestry. In conclusion, the main polymorphism capable of predicting lactose intolerance in Uruguayans is C/T-13910, although more studies are required to unravel the relation between genotype and lactase activity, especially in heterozygotes." @default.
• W4318025815 created "2023-01-26" @default.
• W4318025815 creator A5007252463 @default.
• W4318025815 creator A5014154114 @default.
• W4318025815 creator A5017191562 @default.
• W4318025815 creator A5021900580 @default.
• W4318025815 creator A5022083919 @default.
• W4318025815 creator A5023782187 @default.
• W4318025815 creator A5029505553 @default.
• W4318025815 creator A5033886382 @default.
• W4318025815 creator A5045216398 @default.
• W4318025815 creator A5071845078 @default.
• W4318025815 creator A5076119375 @default.
• W4318025815 date "2023-01-25" @default.
• W4318025815 modified "2023-10-12" @default.
• W4318025815 title "<scp>DNA</scp> polymorphisms associated with lactase persistence, self‐perceived symptoms of lactose intolerance, milk and dairy consumption, and ancestry, in the Uruguayan population" @default.
• W4318025815 cites W1506033718 @default.
• W4318025815 cites W1546019010 @default.
• W4318025815 cites W1546375972 @default.
• W4318025815 cites W1573321052 @default.
• W4318025815 cites W1716554424 @default.
• W4318025815 cites W1761524747 @default.
• W4318025815 cites W1810959788 @default.
• W4318025815 cites W1840299042 @default.
• W4318025815 cites W1912079948 @default.
• W4318025815 cites W1946152840 @default.
• W4318025815 cites W1962625267 @default.
• W4318025815 cites W1965218239 @default.
• W4318025815 cites W1966200346 @default.
• W4318025815 cites W1979765336 @default.
• W4318025815 cites W1980805698 @default.
• W4318025815 cites W1985778344 @default.
• W4318025815 cites W1990074132 @default.
• W4318025815 cites W2001722477 @default.
• W4318025815 cites W2003057252 @default.
• W4318025815 cites W2006731669 @default.
• W4318025815 cites W2010666779 @default.
• W4318025815 cites W2011444597 @default.
• W4318025815 cites W2022106039 @default.
• W4318025815 cites W2022573768 @default.
• W4318025815 cites W2022905671 @default.
• W4318025815 cites W2038640724 @default.
• W4318025815 cites W2042623425 @default.
• W4318025815 cites W2045741747 @default.
• W4318025815 cites W2047299569 @default.
• W4318025815 cites W2047696484 @default.
• W4318025815 cites W2061301918 @default.
• W4318025815 cites W2068713945 @default.
• W4318025815 cites W2081300477 @default.
• W4318025815 cites W2083545762 @default.
• W4318025815 cites W2090781750 @default.
• W4318025815 cites W2096758237 @default.
• W4318025815 cites W2098126593 @default.
• W4318025815 cites W2101307264 @default.
• W4318025815 cites W2110814663 @default.
• W4318025815 cites W2118078855 @default.
• W4318025815 cites W2120551519 @default.
• W4318025815 cites W2121146210 @default.
• W4318025815 cites W2121504310 @default.
• W4318025815 cites W2126374711 @default.
• W4318025815 cites W2152207030 @default.
• W4318025815 cites W2156918287 @default.
• W4318025815 cites W2160865750 @default.
• W4318025815 cites W2169998789 @default.
• W4318025815 cites W2189079163 @default.
• W4318025815 cites W2227382309 @default.
• W4318025815 cites W2242040007 @default.
• W4318025815 cites W2309674 @default.
• W4318025815 cites W2313134415 @default.
• W4318025815 cites W2330797946 @default.
• W4318025815 cites W2336818861 @default.
• W4318025815 cites W2345691423 @default.
• W4318025815 cites W2511541514 @default.
• W4318025815 cites W2528017240 @default.
• W4318025815 cites W2766616055 @default.
• W4318025815 cites W2769730616 @default.
• W4318025815 cites W2794054873 @default.
• W4318025815 cites W2796397025 @default.
• W4318025815 cites W2809958852 @default.
• W4318025815 cites W2885509745 @default.
• W4318025815 cites W2893710883 @default.
• W4318025815 cites W2969489093 @default.
• W4318025815 cites W3029274393 @default.
• W4318025815 cites W3115192749 @default.
• W4318025815 cites W3154843529 @default.
• W4318025815 cites W3201963549 @default.
• W4318025815 cites W4205933267 @default.
• W4318025815 cites W4220922461 @default.
• W4318025815 cites W4251260245 @default.
• W4318025815 cites W4282826044 @default.
• W4318025815 cites W4288051688 @default.
• W4318025815 doi "https://doi.org/10.1002/ajhb.23868" @default.
• W4318025815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36695417" @default.
• W4318025815 hasPublicationYear "2023" @default.
• W4318025815 type Work @default.
• W4318025815 citedByCount "0" @default.
• W4318025815 crossrefType "journal-article" @default.
• W4318025815 hasAuthorship W4318025815A5007252463 @default.
• W4318025815 hasAuthorship W4318025815A5014154114 @default.
• W4318025815 hasAuthorship W4318025815A5017191562 @default.

• next