Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318038808> ?p ?o ?g. }
- W4318038808 abstract "Stiffness and forces are two fundamental quantities essential to living cells and tissues. However, it has been a challenge to quantify both 3D traction forces and stiffness (or modulus) using the same probe in vivo. Here, we describe an approach that overcomes this challenge by creating a magnetic microrobot probe with controllable functionality. Biocompatible ferromagnetic cobalt-platinum microcrosses were fabricated, and each microcross (about 30 micrometers) was trapped inside an arginine–glycine–aspartic acid–conjugated stiff poly(ethylene glycol) (PEG) round microgel (about 50 micrometers) using a microfluidic device. The stiff magnetic microrobot was seeded inside a cell colony and acted as a stiffness probe by rigidly rotating in response to an oscillatory magnetic field. Then, brief episodes of ultraviolet light exposure were applied to dynamically photodegrade and soften the fluorescent nanoparticle–embedded PEG microgel, whose deformation and 3D traction forces were quantified. Using the microrobot probe, we show that malignant tumor–repopulating cell colonies altered their modulus but not traction forces in response to different 3D substrate elasticities. Stiffness and 3D traction forces were measured, and both normal and shear traction force oscillations were observed in zebrafish embryos from blastula to gastrula. Mouse embryos generated larger tensile and compressive traction force oscillations than shear traction force oscillations during blastocyst. The microrobot probe with controllable functionality via magnetic fields could potentially be useful for studying the mechanoregulation of cells, tissues, and embryos." @default.
- W4318038808 created "2023-01-26" @default.
- W4318038808 creator A5001155732 @default.
- W4318038808 creator A5001195029 @default.
- W4318038808 creator A5013549638 @default.
- W4318038808 creator A5020092704 @default.
- W4318038808 creator A5022298216 @default.
- W4318038808 creator A5037165431 @default.
- W4318038808 creator A5048431695 @default.
- W4318038808 creator A5058479146 @default.
- W4318038808 creator A5060013866 @default.
- W4318038808 creator A5072538750 @default.
- W4318038808 creator A5075396443 @default.
- W4318038808 creator A5076551144 @default.
- W4318038808 creator A5082634824 @default.
- W4318038808 creator A5088703357 @default.
- W4318038808 creator A5058449379 @default.
- W4318038808 date "2023-01-25" @default.
- W4318038808 modified "2023-10-17" @default.
- W4318038808 title "Quantifying stiffness and forces of tumor colonies and embryos using a magnetic microrobot" @default.
- W4318038808 cites W1519287420 @default.
- W4318038808 cites W1587510658 @default.
- W4318038808 cites W1969583173 @default.
- W4318038808 cites W1982300430 @default.
- W4318038808 cites W1985188216 @default.
- W4318038808 cites W1999531676 @default.
- W4318038808 cites W2013268726 @default.
- W4318038808 cites W2025522134 @default.
- W4318038808 cites W2030365976 @default.
- W4318038808 cites W2033778338 @default.
- W4318038808 cites W2040923825 @default.
- W4318038808 cites W2048942861 @default.
- W4318038808 cites W2052766715 @default.
- W4318038808 cites W2056071002 @default.
- W4318038808 cites W2059294330 @default.
- W4318038808 cites W2060932651 @default.
- W4318038808 cites W2064883155 @default.
- W4318038808 cites W2074572112 @default.
- W4318038808 cites W2077534656 @default.
- W4318038808 cites W2097679878 @default.
- W4318038808 cites W2110834542 @default.
- W4318038808 cites W2110947634 @default.
- W4318038808 cites W2111412288 @default.
- W4318038808 cites W2111811045 @default.
- W4318038808 cites W2112346252 @default.
- W4318038808 cites W2120000044 @default.
- W4318038808 cites W2125644189 @default.
- W4318038808 cites W2128193911 @default.
- W4318038808 cites W2134208433 @default.
- W4318038808 cites W2138402450 @default.
- W4318038808 cites W2158200659 @default.
- W4318038808 cites W2170669827 @default.
- W4318038808 cites W2322443154 @default.
- W4318038808 cites W2396408168 @default.
- W4318038808 cites W2407187619 @default.
- W4318038808 cites W2442006539 @default.
- W4318038808 cites W2474732353 @default.
- W4318038808 cites W2482879788 @default.
- W4318038808 cites W2513294073 @default.
- W4318038808 cites W2546306361 @default.
- W4318038808 cites W2560819934 @default.
- W4318038808 cites W2567196260 @default.
- W4318038808 cites W2573773978 @default.
- W4318038808 cites W2582805839 @default.
- W4318038808 cites W2646476739 @default.
- W4318038808 cites W2649736046 @default.
- W4318038808 cites W2791260982 @default.
- W4318038808 cites W2800907032 @default.
- W4318038808 cites W2803226231 @default.
- W4318038808 cites W2808157488 @default.
- W4318038808 cites W2890183842 @default.
- W4318038808 cites W2891109293 @default.
- W4318038808 cites W2908803977 @default.
- W4318038808 cites W2914936371 @default.
- W4318038808 cites W2944567014 @default.
- W4318038808 cites W2949965082 @default.
- W4318038808 cites W2966429158 @default.
- W4318038808 cites W2989757152 @default.
- W4318038808 cites W2991002539 @default.
- W4318038808 cites W3000567036 @default.
- W4318038808 cites W3026805816 @default.
- W4318038808 cites W3081299326 @default.
- W4318038808 cites W3082639090 @default.
- W4318038808 cites W3090294989 @default.
- W4318038808 cites W3098821454 @default.
- W4318038808 cites W3137317508 @default.
- W4318038808 cites W3138491198 @default.
- W4318038808 cites W3139736334 @default.
- W4318038808 cites W3150248096 @default.
- W4318038808 cites W3155636143 @default.
- W4318038808 cites W4223931121 @default.
- W4318038808 cites W4290805650 @default.
- W4318038808 cites W4293247374 @default.
- W4318038808 doi "https://doi.org/10.1126/scirobotics.adc9800" @default.
- W4318038808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36696474" @default.
- W4318038808 hasPublicationYear "2023" @default.
- W4318038808 type Work @default.
- W4318038808 citedByCount "8" @default.
- W4318038808 countsByYear W43180388082023 @default.
- W4318038808 crossrefType "journal-article" @default.