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• W4318052373 endingPage "944" @default.
• W4318052373 startingPage "944" @default.
• W4318052373 abstract "A correlation between mental illness and systemic rheumatoid arthritis (RA) has been observed in several prior investigations. However, little is known about the causative relationship between them. The present study aimed to systematically investigate the potential association between genetically determined mental illness and RA. Two-sample bidirectional Mendelian randomization (MR) analysis was performed using publicly released genome-wide association studies (GWAS). We selected independent genetic variants associated with four mental illnesses (bipolar disorder, broad depression, major depression, and anxiety) as instrumental variables. The inverse variance weighted (IVW) method was used as the primary analysis to assess the causal relationship between mental illness and RA. Results of the IVW analysis suggested that genetic predisposition to bipolar disorder was associated with a decreased risk of RA (odds ratio [OR] = 0.825, 95% CI = 0.716 to 0.95, p = 0.007). Furthermore, we did not find a significant causal effect of RA on bipolar disorder in the reverse MR analysis (p > 0.05). In addition, our study found no evidence of a bidirectional causal relationship between genetically predicted broad depression, major depression, anxiety, and RA (p > 0.05). The genetically proxied bipolar disorder population has a lower RA risk, which may indicate that there is a hidden mechanism for inhibiting the pathogenesis of RA in bipolar disorder. However, results do not support a causal connection between depression, anxiety, and RA." @default.
• W4318052373 created "2023-01-26" @default.
• W4318052373 creator A5004691250 @default.
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• W4318052373 creator A5065294383 @default.
• W4318052373 date "2023-01-25" @default.
• W4318052373 modified "2023-09-26" @default.
• W4318052373 title "Assessment of Bidirectional Relationships between Mental Illness and Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study" @default.
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• W4318052373 doi "https://doi.org/10.3390/jcm12030944" @default.
• W4318052373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36769592" @default.
• W4318052373 hasPublicationYear "2023" @default.

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