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- W4318055131 abstract "Liver cancers are rising worldwide. Between molecular and epidemiological studies, a research gap has emerged which might be amenable to the technique of metabolomics. This review investigates the current understanding of liver cancer’s trends, etiology and its correlates with existing literature for hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and hepatoblastoma (HB). Among additional factors, the literature reports dysfunction in the tricarboxylic acid metabolism, primarily for HB and HCC, and point mutations and signaling for CCA. All cases require further investigation of upstream and downstream events. All liver cancers reported dysfunction in the WNT/β-catenin and P13K/AKT/mTOR pathways as well as changes in FGFR. Metabolites of IHD1, IDH2, miRNA, purine, Q10, lipids, phosphatidylcholine, phosphatidylethanolamine, acylcarnitine, 2-HG and propionyl-CoA emerged as crucial and there was an attempt to elucidate the WNT/β-catenin and P13K/AKT/mTOR pathways metabolomically." @default.
- W4318055131 created "2023-01-26" @default.
- W4318055131 creator A5075239708 @default.
- W4318055131 date "2023-01-26" @default.
- W4318055131 modified "2023-10-14" @default.
- W4318055131 title "Primary Liver Cancers: Connecting the Dots of Cellular Studies and Epidemiology with Metabolomics" @default.
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- W4318055131 doi "https://doi.org/10.3390/ijms24032409" @default.
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