FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318071648> ?p ?o ?g. }

• W4318071648 endingPage "192" @default.
• W4318071648 startingPage "184" @default.
• W4318071648 abstract "Cancer therapies often have narrow therapeutic indexes and involve potentially suboptimal combinations due to the dissimilar physical properties of drug molecules. Nanomedicine platforms could address these challenges, but it remains unclear whether synergistic free-drug ratios translate to nanocarriers and whether nanocarriers with multiple drugs outperform mixtures of single-drug nanocarriers at the same dose. Here we report a bottlebrush prodrug (BPD) platform designed to answer these questions in the context of multiple myeloma therapy. We show that proteasome inhibitor (bortezomib)-based BPD monotherapy slows tumour progression in vivo and that mixtures of bortezomib, pomalidomide and dexamethasone BPDs exhibit in vitro synergistic, additive or antagonistic patterns distinct from their corresponding free-drug counterparts. BPDs carrying a statistical mixture of three drugs in a synergistic ratio outperform the free-drug combination at the same ratio as well as a mixture of single-drug BPDs in the same ratio. Our results address unanswered questions in the field of nanomedicine, offering design principles for combination nanomedicines and strategies for improving current front-line monotherapies and combination therapies for multiple myeloma. Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. Here we use a bottlebrush prodrug platform to show that the delivery of three drugs in a synergistic combination in animal models outperforms other combinatorial approaches for multiple myeloma therapy." @default.
• W4318071648 created "2023-01-26" @default.
• W4318071648 creator A5010920250 @default.
• W4318071648 creator A5019827043 @default.
• W4318071648 creator A5020163280 @default.
• W4318071648 creator A5023152679 @default.
• W4318071648 creator A5037623190 @default.
• W4318071648 creator A5046555808 @default.
• W4318071648 creator A5050216568 @default.
• W4318071648 creator A5053899175 @default.
• W4318071648 creator A5058975949 @default.
• W4318071648 creator A5059372278 @default.
• W4318071648 creator A5083383687 @default.
• W4318071648 creator A5087243761 @default.
• W4318071648 creator A5090383572 @default.
• W4318071648 date "2023-01-26" @default.
• W4318071648 modified "2023-10-17" @default.
• W4318071648 title "Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma" @default.
• W4318071648 cites W1977096237 @default.
• W4318071648 cites W1978450665 @default.
• W4318071648 cites W1986297232 @default.
• W4318071648 cites W2003426760 @default.
• W4318071648 cites W2027748446 @default.
• W4318071648 cites W2037041572 @default.
• W4318071648 cites W2037834319 @default.
• W4318071648 cites W2044025814 @default.
• W4318071648 cites W2044210828 @default.
• W4318071648 cites W2061136308 @default.
• W4318071648 cites W2066484074 @default.
• W4318071648 cites W2069650869 @default.
• W4318071648 cites W2089220360 @default.
• W4318071648 cites W2112520576 @default.
• W4318071648 cites W2133460568 @default.
• W4318071648 cites W2136112505 @default.
• W4318071648 cites W2140050472 @default.
• W4318071648 cites W2150375936 @default.
• W4318071648 cites W2158470474 @default.
• W4318071648 cites W2162994503 @default.
• W4318071648 cites W2165921162 @default.
• W4318071648 cites W2166059514 @default.
• W4318071648 cites W2231813729 @default.
• W4318071648 cites W2250131397 @default.
• W4318071648 cites W2313479778 @default.
• W4318071648 cites W2317470873 @default.
• W4318071648 cites W2336887413 @default.
• W4318071648 cites W2417973730 @default.
• W4318071648 cites W2554773181 @default.
• W4318071648 cites W2592741852 @default.
• W4318071648 cites W2604776612 @default.
• W4318071648 cites W2605513926 @default.
• W4318071648 cites W2617810686 @default.
• W4318071648 cites W2744506252 @default.
• W4318071648 cites W2769675217 @default.
• W4318071648 cites W2789284856 @default.
• W4318071648 cites W2803943628 @default.
• W4318071648 cites W2883399820 @default.
• W4318071648 cites W2886628870 @default.
• W4318071648 cites W2888796054 @default.
• W4318071648 cites W2902475776 @default.
• W4318071648 cites W2913256870 @default.
• W4318071648 cites W2914103534 @default.
• W4318071648 cites W2947758032 @default.
• W4318071648 cites W2948892687 @default.
• W4318071648 cites W2979634134 @default.
• W4318071648 cites W3047623209 @default.
• W4318071648 cites W3082071662 @default.
• W4318071648 cites W3083246189 @default.
• W4318071648 cites W3109746568 @default.
• W4318071648 cites W3135153012 @default.
• W4318071648 doi "https://doi.org/10.1038/s41565-022-01310-1" @default.
• W4318071648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36702954" @default.
• W4318071648 hasPublicationYear "2023" @default.
• W4318071648 type Work @default.
• W4318071648 citedByCount "16" @default.
• W4318071648 countsByYear W43180716482023 @default.
• W4318071648 crossrefType "journal-article" @default.
• W4318071648 hasAuthorship W4318071648A5010920250 @default.
• W4318071648 hasAuthorship W4318071648A5019827043 @default.
• W4318071648 hasAuthorship W4318071648A5020163280 @default.
• W4318071648 hasAuthorship W4318071648A5023152679 @default.
• W4318071648 hasAuthorship W4318071648A5037623190 @default.
• W4318071648 hasAuthorship W4318071648A5046555808 @default.
• W4318071648 hasAuthorship W4318071648A5050216568 @default.
• W4318071648 hasAuthorship W4318071648A5053899175 @default.
• W4318071648 hasAuthorship W4318071648A5058975949 @default.
• W4318071648 hasAuthorship W4318071648A5059372278 @default.
• W4318071648 hasAuthorship W4318071648A5083383687 @default.
• W4318071648 hasAuthorship W4318071648A5087243761 @default.
• W4318071648 hasAuthorship W4318071648A5090383572 @default.
• W4318071648 hasBestOaLocation W43180716482 @default.
• W4318071648 hasConcept C108215921 @default.
• W4318071648 hasConcept C126322002 @default.
• W4318071648 hasConcept C15083742 @default.
• W4318071648 hasConcept C150903083 @default.
• W4318071648 hasConcept C151730666 @default.
• W4318071648 hasConcept C155672457 @default.
• W4318071648 hasConcept C171250308 @default.
• W4318071648 hasConcept C18150654 @default.

• next