Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318165121> ?p ?o ?g. }
- W4318165121 endingPage "e1436" @default.
- W4318165121 startingPage "e1436" @default.
- W4318165121 abstract "Background. The THEORY study evaluated the effects of single and multiple doses of obinutuzumab, a type 2 anti-CD20 antibody that induces antibody-dependent cell-mediated cytotoxicity and direct cell death, in combination with standard of care in patients with end-stage renal disease. Methods. We measured B-cell subsets and protein biomarkers of B-cell activity in peripheral blood before and after obinutuzumab administration in THEORY patients, and B-cell subsets in lymph nodes in THEORY patients and an untreated comparator cohort. Results. Obinutuzumab treatment resulted in a rapid loss of B-cell subsets (including naive B, memory B, double-negative, immunoglobulin D+ transitional cells, and plasmablasts/plasma cells) in peripheral blood and tissue. This loss of B cells was associated with increased B cell–activating factor and decreased CXCL13 levels in circulation. Conclusions. Our data further characterize the mechanistic profile of obinutuzumab and suggest that it may elicit greater efficacy in indications such as lupus where B-cell targeting therapeutics are limited by the resistance of pathogenic tissue B cells to depletion." @default.
- W4318165121 created "2023-01-27" @default.
- W4318165121 creator A5011138279 @default.
- W4318165121 creator A5019002307 @default.
- W4318165121 creator A5021095117 @default.
- W4318165121 creator A5023775622 @default.
- W4318165121 creator A5026789430 @default.
- W4318165121 creator A5030789303 @default.
- W4318165121 creator A5034783527 @default.
- W4318165121 creator A5036380035 @default.
- W4318165121 creator A5046091581 @default.
- W4318165121 creator A5050293355 @default.
- W4318165121 creator A5054506083 @default.
- W4318165121 creator A5061876034 @default.
- W4318165121 creator A5062810481 @default.
- W4318165121 creator A5076161489 @default.
- W4318165121 creator A5076738806 @default.
- W4318165121 date "2023-01-19" @default.
- W4318165121 modified "2023-09-27" @default.
- W4318165121 title "Obinutuzumab Effectively Depletes Key B-cell Subsets in Blood and Tissue in End-stage Renal Disease Patients" @default.
- W4318165121 cites W1581336840 @default.
- W4318165121 cites W1966348678 @default.
- W4318165121 cites W1982911537 @default.
- W4318165121 cites W1985380203 @default.
- W4318165121 cites W1989273660 @default.
- W4318165121 cites W1991863290 @default.
- W4318165121 cites W1992988295 @default.
- W4318165121 cites W2042725832 @default.
- W4318165121 cites W2050619107 @default.
- W4318165121 cites W2067733905 @default.
- W4318165121 cites W2083794349 @default.
- W4318165121 cites W2084547554 @default.
- W4318165121 cites W2091057822 @default.
- W4318165121 cites W2096428863 @default.
- W4318165121 cites W2107008240 @default.
- W4318165121 cites W2120319857 @default.
- W4318165121 cites W2126595174 @default.
- W4318165121 cites W2129961994 @default.
- W4318165121 cites W2135802989 @default.
- W4318165121 cites W2142577589 @default.
- W4318165121 cites W2156049613 @default.
- W4318165121 cites W2156099217 @default.
- W4318165121 cites W2162387968 @default.
- W4318165121 cites W2286883753 @default.
- W4318165121 cites W2509096421 @default.
- W4318165121 cites W2564284206 @default.
- W4318165121 cites W2766572113 @default.
- W4318165121 cites W2800709983 @default.
- W4318165121 cites W2888559184 @default.
- W4318165121 cites W2896763394 @default.
- W4318165121 cites W2949631571 @default.
- W4318165121 cites W2950598879 @default.
- W4318165121 cites W2954014213 @default.
- W4318165121 cites W2965040444 @default.
- W4318165121 cites W3016078453 @default.
- W4318165121 cites W3080966974 @default.
- W4318165121 cites W3202510981 @default.
- W4318165121 cites W33733012 @default.
- W4318165121 cites W4241404134 @default.
- W4318165121 cites W4245690133 @default.
- W4318165121 cites W4254647395 @default.
- W4318165121 doi "https://doi.org/10.1097/txd.0000000000001436" @default.
- W4318165121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36700064" @default.
- W4318165121 hasPublicationYear "2023" @default.
- W4318165121 type Work @default.
- W4318165121 citedByCount "0" @default.
- W4318165121 crossrefType "journal-article" @default.
- W4318165121 hasAuthorship W4318165121A5011138279 @default.
- W4318165121 hasAuthorship W4318165121A5019002307 @default.
- W4318165121 hasAuthorship W4318165121A5021095117 @default.
- W4318165121 hasAuthorship W4318165121A5023775622 @default.
- W4318165121 hasAuthorship W4318165121A5026789430 @default.
- W4318165121 hasAuthorship W4318165121A5030789303 @default.
- W4318165121 hasAuthorship W4318165121A5034783527 @default.
- W4318165121 hasAuthorship W4318165121A5036380035 @default.
- W4318165121 hasAuthorship W4318165121A5046091581 @default.
- W4318165121 hasAuthorship W4318165121A5050293355 @default.
- W4318165121 hasAuthorship W4318165121A5054506083 @default.
- W4318165121 hasAuthorship W4318165121A5061876034 @default.
- W4318165121 hasAuthorship W4318165121A5062810481 @default.
- W4318165121 hasAuthorship W4318165121A5076161489 @default.
- W4318165121 hasAuthorship W4318165121A5076738806 @default.
- W4318165121 hasBestOaLocation W43181651211 @default.
- W4318165121 hasConcept C126322002 @default.
- W4318165121 hasConcept C159654299 @default.
- W4318165121 hasConcept C18031839 @default.
- W4318165121 hasConcept C203014093 @default.
- W4318165121 hasConcept C2777607594 @default.
- W4318165121 hasConcept C2778453870 @default.
- W4318165121 hasConcept C71924100 @default.
- W4318165121 hasConceptScore W4318165121C126322002 @default.
- W4318165121 hasConceptScore W4318165121C159654299 @default.
- W4318165121 hasConceptScore W4318165121C18031839 @default.
- W4318165121 hasConceptScore W4318165121C203014093 @default.
- W4318165121 hasConceptScore W4318165121C2777607594 @default.
- W4318165121 hasConceptScore W4318165121C2778453870 @default.
- W4318165121 hasConceptScore W4318165121C71924100 @default.
- W4318165121 hasIssue "2" @default.