FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318200090> ?p ?o ?g. }

• W4318200090 abstract "It is well-documented that pro-inflammatory cytokines and inflammation play a significant role in the expansion of cancer disease. Gallic acid (GA), a natural compound, and metformin (Met), a synthetic drug exhibit potent anticancer potential via the distinct molecular mechanism. However, whether both these compounds can act synergistically to preclude and treat cancer is still unknown. This prompted us to scrutinize, the synergism between GA and Met, and that of a new co-drug synthesizing of GA and Met (GA-Met) and investigated the chemo-protective effect against breast cancer with possible intervention of cytokines. In vivo studies were based on chemical carcinogenesis, challenging breast tissue by dimethylbenz[α]anthracene (DMBA). Tumour incidence, tumour burden, pro-inflammatory cytokines in serum, breast, hepatic tissue, macroscopically and histological analysis of mammary tumours were carried out and estimated. GA, Met and GA-Met co-drug exhibited the inhibition of cell proliferation; higher reduction of cell proliferation was observed by GA-Met. The inhibitory effect of GA-Met was linked to cell cycle arrest at G0/G1 phase, along with induction of apoptosis and accumulation in the sub-G1 phase. GA-Met significantly inhibited the cytokines production along with protection against DMBA-induced hyperplasia. Taken altogether, the current result suggests that GA-Met co-drug endows a safe and protective effect against cancer metastasis and can possibly use for the treatment of human breast cancer." @default.
• W4318200090 created "2023-01-27" @default.
• W4318200090 creator A5015407616 @default.
• W4318200090 creator A5027834798 @default.
• W4318200090 creator A5041107386 @default.
• W4318200090 creator A5049842965 @default.
• W4318200090 creator A5055749314 @default.
• W4318200090 creator A5058647295 @default.
• W4318200090 creator A5083547876 @default.
• W4318200090 date "2023-01-26" @default.
• W4318200090 modified "2023-10-11" @default.
• W4318200090 title "Co‐drug development of gallic acid and metformin targeting the pro‐inflammatory cytokines for the treatment of breast cancer" @default.
• W4318200090 cites W1106420127 @default.
• W4318200090 cites W1493833135 @default.
• W4318200090 cites W1961026612 @default.
• W4318200090 cites W1969327150 @default.
• W4318200090 cites W1990063646 @default.
• W4318200090 cites W1995063896 @default.
• W4318200090 cites W1996182515 @default.
• W4318200090 cites W2004975959 @default.
• W4318200090 cites W2008181517 @default.
• W4318200090 cites W2012479775 @default.
• W4318200090 cites W2020474316 @default.
• W4318200090 cites W2022488654 @default.
• W4318200090 cites W2026967508 @default.
• W4318200090 cites W2041853090 @default.
• W4318200090 cites W2054211750 @default.
• W4318200090 cites W2064018079 @default.
• W4318200090 cites W2083751708 @default.
• W4318200090 cites W2091099722 @default.
• W4318200090 cites W2094222260 @default.
• W4318200090 cites W2096283457 @default.
• W4318200090 cites W2098257287 @default.
• W4318200090 cites W2116404316 @default.
• W4318200090 cites W2119437574 @default.
• W4318200090 cites W2125292576 @default.
• W4318200090 cites W2125747634 @default.
• W4318200090 cites W2128380182 @default.
• W4318200090 cites W2134295452 @default.
• W4318200090 cites W2144026946 @default.
• W4318200090 cites W2148755064 @default.
• W4318200090 cites W2148784782 @default.
• W4318200090 cites W2161817637 @default.
• W4318200090 cites W2164664027 @default.
• W4318200090 cites W2215629512 @default.
• W4318200090 cites W2332912393 @default.
• W4318200090 cites W2556599706 @default.
• W4318200090 cites W2790538011 @default.
• W4318200090 cites W2799945513 @default.
• W4318200090 cites W2995027661 @default.
• W4318200090 cites W3036960489 @default.
• W4318200090 cites W4238295540 @default.
• W4318200090 doi "https://doi.org/10.1002/jbt.23300" @default.
• W4318200090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36703564" @default.
• W4318200090 hasPublicationYear "2023" @default.
• W4318200090 type Work @default.
• W4318200090 citedByCount "1" @default.
• W4318200090 crossrefType "journal-article" @default.
• W4318200090 hasAuthorship W4318200090A5015407616 @default.
• W4318200090 hasAuthorship W4318200090A5027834798 @default.
• W4318200090 hasAuthorship W4318200090A5041107386 @default.
• W4318200090 hasAuthorship W4318200090A5049842965 @default.
• W4318200090 hasAuthorship W4318200090A5055749314 @default.
• W4318200090 hasAuthorship W4318200090A5058647295 @default.
• W4318200090 hasAuthorship W4318200090A5083547876 @default.
• W4318200090 hasConcept C121608353 @default.
• W4318200090 hasConcept C126322002 @default.
• W4318200090 hasConcept C150903083 @default.
• W4318200090 hasConcept C164027704 @default.
• W4318200090 hasConcept C185592680 @default.
• W4318200090 hasConcept C190283241 @default.
• W4318200090 hasConcept C203014093 @default.
• W4318200090 hasConcept C207001950 @default.
• W4318200090 hasConcept C2776914184 @default.
• W4318200090 hasConcept C2778938436 @default.
• W4318200090 hasConcept C2779013556 @default.
• W4318200090 hasConcept C502942594 @default.
• W4318200090 hasConcept C530470458 @default.
• W4318200090 hasConcept C55493867 @default.
• W4318200090 hasConcept C555283112 @default.
• W4318200090 hasConcept C62112901 @default.
• W4318200090 hasConcept C71924100 @default.
• W4318200090 hasConcept C86803240 @default.
• W4318200090 hasConcept C98274493 @default.
• W4318200090 hasConceptScore W4318200090C121608353 @default.
• W4318200090 hasConceptScore W4318200090C126322002 @default.
• W4318200090 hasConceptScore W4318200090C150903083 @default.
• W4318200090 hasConceptScore W4318200090C164027704 @default.
• W4318200090 hasConceptScore W4318200090C185592680 @default.
• W4318200090 hasConceptScore W4318200090C190283241 @default.
• W4318200090 hasConceptScore W4318200090C203014093 @default.
• W4318200090 hasConceptScore W4318200090C207001950 @default.
• W4318200090 hasConceptScore W4318200090C2776914184 @default.
• W4318200090 hasConceptScore W4318200090C2778938436 @default.
• W4318200090 hasConceptScore W4318200090C2779013556 @default.
• W4318200090 hasConceptScore W4318200090C502942594 @default.
• W4318200090 hasConceptScore W4318200090C530470458 @default.
• W4318200090 hasConceptScore W4318200090C55493867 @default.
• W4318200090 hasConceptScore W4318200090C555283112 @default.
• W4318200090 hasConceptScore W4318200090C62112901 @default.

• next