FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318200575> ?p ?o ?g. }

• W4318200575 abstract "With the increasing incidence of tuberculosis (TB) and the shortcomings of existing TB vaccines to prevent TB in adults, new TB vaccines need to be developed to address the complex TB epidemic.The dominant epitopes were screened from antigens to construct a novel epitope vaccine termed HP13138PB. The immune properties, structure, and function of HP13138PB were predicted and analyzed with bioinformatics and immunoinformatics. Then, the immune responses induced by the HP13138PB were confirmed by enzyme-linked immunospot assay (ELISPOT) and Th1/Th2/Th17 multi-cytokine detection kit.The HP13138PB vaccine consisted of 13 helper T lymphocytes (HTL) epitopes, 13 cytotoxic T lymphocytes (CTL) epitopes, and 8 B-cell epitopes. It was found that the antigenicity, immunogenicity, and solubility index of the HP13138PB vaccine were 0.87, 2.79, and 0.55, respectively. The secondary structure prediction indicated that the HP13138PB vaccine had 31% of α-helix, 11% of β-strand, and 56% of coil. The tertiary structure analysis suggested that the Z-score and the Favored region of the HP13138PB vaccine were -4.47 88.22%, respectively. Furthermore, the binding energies of the HP13138PB to toll-like receptor 2 (TLR2) was -1224.7 kcal/mol. The immunoinformatics and real-world experiments showed that the HP13138PB vaccine could induce an innate and adaptive immune response characterized by significantly higher levels of cytokines such as interferon-gamma (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), and IL-10.The HP13138PB is a potential vaccine candidate to prevent TB, and this study preliminarily evaluated the ability of the HP13138PB to generate an immune response, providing a precursor target for developing TB vaccines." @default.
• W4318200575 created "2023-01-27" @default.
• W4318200575 creator A5029118612 @default.
• W4318200575 creator A5056592037 @default.
• W4318200575 creator A5060680516 @default.
• W4318200575 creator A5075877965 @default.
• W4318200575 creator A5086664647 @default.
• W4318200575 creator A5086952340 @default.
• W4318200575 creator A5088734670 @default.
• W4318200575 date "2023-01-27" @default.
• W4318200575 modified "2023-10-04" @default.
• W4318200575 title "Bioinformatics analysis and consistency verification of a novel tuberculosis vaccine candidate HP13138PB" @default.
• W4318200575 cites W1546213590 @default.
• W4318200575 cites W1973980688 @default.
• W4318200575 cites W1987134040 @default.
• W4318200575 cites W1992192767 @default.
• W4318200575 cites W1995744610 @default.
• W4318200575 cites W1998917415 @default.
• W4318200575 cites W2010318115 @default.
• W4318200575 cites W2013245073 @default.
• W4318200575 cites W2014274241 @default.
• W4318200575 cites W2015176909 @default.
• W4318200575 cites W2021530329 @default.
• W4318200575 cites W2028147409 @default.
• W4318200575 cites W2035240910 @default.
• W4318200575 cites W2074473216 @default.
• W4318200575 cites W2084536752 @default.
• W4318200575 cites W2097874743 @default.
• W4318200575 cites W2102367710 @default.
• W4318200575 cites W2105509248 @default.
• W4318200575 cites W2110298304 @default.
• W4318200575 cites W2127635589 @default.
• W4318200575 cites W2127814614 @default.
• W4318200575 cites W2142529984 @default.
• W4318200575 cites W2151932306 @default.
• W4318200575 cites W2164291463 @default.
• W4318200575 cites W2171268876 @default.
• W4318200575 cites W2171295581 @default.
• W4318200575 cites W2198680254 @default.
• W4318200575 cites W2216203568 @default.
• W4318200575 cites W2425697116 @default.
• W4318200575 cites W2561826764 @default.
• W4318200575 cites W2618718964 @default.
• W4318200575 cites W2620185010 @default.
• W4318200575 cites W2751476102 @default.
• W4318200575 cites W2804822363 @default.
• W4318200575 cites W2874474540 @default.
• W4318200575 cites W2910861679 @default.
• W4318200575 cites W2946512810 @default.
• W4318200575 cites W2956084568 @default.
• W4318200575 cites W2968560894 @default.
• W4318200575 cites W2969716533 @default.
• W4318200575 cites W2972594981 @default.
• W4318200575 cites W2982353502 @default.
• W4318200575 cites W2990172995 @default.
• W4318200575 cites W3000149137 @default.
• W4318200575 cites W3003716263 @default.
• W4318200575 cites W3007680806 @default.
• W4318200575 cites W3016073437 @default.
• W4318200575 cites W3039803225 @default.
• W4318200575 cites W3040870189 @default.
• W4318200575 cites W3124236370 @default.
• W4318200575 cites W3157636232 @default.
• W4318200575 cites W3158136618 @default.
• W4318200575 cites W3160780424 @default.
• W4318200575 cites W3173512910 @default.
• W4318200575 cites W3183937602 @default.
• W4318200575 cites W3202258953 @default.
• W4318200575 cites W3205728272 @default.
• W4318200575 cites W4200285860 @default.
• W4318200575 cites W4210802320 @default.
• W4318200575 cites W4281787968 @default.
• W4318200575 cites W4283586221 @default.
• W4318200575 cites W4283639777 @default.
• W4318200575 cites W4284879563 @default.
• W4318200575 cites W4289653737 @default.
• W4318200575 cites W4290723741 @default.
• W4318200575 cites W4307862924 @default.
• W4318200575 doi "https://doi.org/10.3389/fimmu.2023.1102578" @default.
• W4318200575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36825009" @default.
• W4318200575 hasPublicationYear "2023" @default.
• W4318200575 type Work @default.
• W4318200575 citedByCount "4" @default.
• W4318200575 countsByYear W43182005752023 @default.
• W4318200575 crossrefType "journal-article" @default.
• W4318200575 hasAuthorship W4318200575A5029118612 @default.
• W4318200575 hasAuthorship W4318200575A5056592037 @default.
• W4318200575 hasAuthorship W4318200575A5060680516 @default.
• W4318200575 hasAuthorship W4318200575A5075877965 @default.
• W4318200575 hasAuthorship W4318200575A5086664647 @default.
• W4318200575 hasAuthorship W4318200575A5086952340 @default.
• W4318200575 hasAuthorship W4318200575A5088734670 @default.
• W4318200575 hasBestOaLocation W43182005751 @default.
• W4318200575 hasConcept C142724271 @default.
• W4318200575 hasConcept C147483822 @default.
• W4318200575 hasConcept C159047783 @default.
• W4318200575 hasConcept C195616568 @default.
• W4318200575 hasConcept C203014093 @default.
• W4318200575 hasConcept C22070199 @default.
• W4318200575 hasConcept C2776090121 @default.

• next