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- W4318218037 abstract "Fibrillary glomerulopathy represents an uncommon glomerular disease of organised deposits that is diagnosed in 0.5–1% of native renal biopsies. It was first reported by Rosenmann and Eliakim in 1977 as a glomerulopathy with a material very similar to amyloid that did not stain with Congo red. Until recently, this entity was diagnosed based on finding from histology and electron microscopy. In the last few years, it has been shown that identification of heat-shock protein DNAJB9 immunostaining within these deposits is a reliable tool in the diagnosis of fibrillary glomerulopathy.1,2 This is a case of a 69-year-old female with features of proteinuria, intermittent low grade microscopic haematuria and an eGFR of 62. On histology there was significant mesangial predominant deposition of PAS positive and silver negative material, that demonstrated IgG dominant and DNAJB9 positive immunostaining. Electron microscopy later confirmed the presence of randomly arranged fibrils demonstrating a diameter within the range of 14 to 23 nm. This case of fibrillary glomerulopathy with positive DNAJB9 immunostaining has been reported as a means for review of the current literature regarding the use of DNAJB9 as a marker for fibrillary glomerulopathy. References 1. Andeen NK, Troxell ML, Riazy M, et al. Fibrillary glomerulonephritis: clinicopathologic features and atypical cases from a multi-institutional cohort. CJASN 2019; 14: 1741–1750. 2. Nasr SH, Vrana JA, Dasari S. DNAJB9 is a specific immunohistochemical marker for fibrillary glomerulonephritis. Kidney Int Rep 2017; 3: 56–64." @default.
- W4318218037 created "2023-01-27" @default.
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- W4318218037 date "2023-02-01" @default.
- W4318218037 modified "2023-09-29" @default.
- W4318218037 title "Fibrillary glomerulopathy and DNAJB9 immunohistochemistry: case report and literature review" @default.
- W4318218037 doi "https://doi.org/10.1016/j.pathol.2022.12.233" @default.
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