Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318219023> ?p ?o ?g. }
- W4318219023 abstract "Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it remains refractory to systemic therapy. Elimination of senescent cells has emerged as a promising new treatment approach against cancer. Here, we investigated the contribution of senescent cells to GBM progression. Senescent cells are identified in patient and mouse GBMs. Partial removal of p16Ink4a-expressing malignant senescent cells, which make up less than 7 % of the tumor, modifies the tumor ecosystem and improves the survival of GBM-bearing female mice. By combining single cell and bulk RNA sequencing, immunohistochemistry and genetic knockdowns, we identify the NRF2 transcription factor as a determinant of the senescent phenotype. Remarkably, our mouse senescent transcriptional signature and underlying mechanisms of senescence are conserved in patient GBMs, in whom higher senescence scores correlate with shorter survival times. These findings suggest that senolytic drug therapy may be a beneficial adjuvant therapy for patients with GBM." @default.
- W4318219023 created "2023-01-27" @default.
- W4318219023 creator A5013758279 @default.
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- W4318219023 creator A5085149424 @default.
- W4318219023 creator A5089277246 @default.
- W4318219023 date "2023-01-27" @default.
- W4318219023 modified "2023-10-16" @default.
- W4318219023 title "Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma" @default.
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