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- W4318225000 endingPage "1962" @default.
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- W4318225000 abstract "Transition metal catalysis has revolutionized modern synthetic chemistry for its diverse modes of coordination reactivity. However, this versatility in reactivity is also the predominant cause of catalyst deactivation, a persisting issue that can significantly compromise its synthetic value. Homeostatic catalysis, a catalytic process that can sustain its productive catalytic cycle even when chemically disturbed, is proposed herein as an effective tactic to address the challenge. In particular, a cobalt homeostatic catalysis process has been developed for the water-tolerant coupling of enaminones and oxadiazolones to quinazolinones. Dynamic covalent bonding serves as a mechanistic handle for the preferred buffering of water onto enaminone and reverse exchange by a released secondary amine, thus securing reversible entry into cobalt's dormant and active states for productive catalysis. Through this homeostatic catalysis mode, a broad structural scope has been achieved for quinazolinones, enabling further elaboration into distinct pharmaceutically active agents." @default.
- W4318225000 created "2023-01-27" @default.
- W4318225000 creator A5009141567 @default.
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- W4318225000 creator A5026831130 @default.
- W4318225000 creator A5073746375 @default.
- W4318225000 creator A5080619378 @default.
- W4318225000 date "2023-01-27" @default.
- W4318225000 modified "2023-10-06" @default.
- W4318225000 title "Cobalt Homeostatic Catalysis for Coupling of Enaminones and Oxadiazolones to Quinazolinones" @default.
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- W4318225000 doi "https://doi.org/10.1021/acs.joc.2c01934" @default.
- W4318225000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36705660" @default.
- W4318225000 hasPublicationYear "2023" @default.
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