Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318256694> ?p ?o ?g. }
- W4318256694 abstract "Malaria is a disease caused by Plasmodium spp. protozoa. The ability of Plasmodium to develop resistance to current antimalarial drugs makes the study of chemotherapeutic alternatives extremely important. This study aimed to evaluate the antimalarial activity of compound 3286938 (1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one), which presents in its structure a 3,4,5-trimethoxyphenyl group, in vitro, using the W2 strain of P. falciparum and against circulating strains of P. vivax and P. falciparum from the state of Rondônia. The compound 3286938 obtained an IC50 of 24.4 µM against the W2 strain of P. falciparum, and against the circulating strains, it presented a median (MD)=38.7 µM for P. vivax and MD=6.7 µM for P. falciparum. As for toxicity, 3286938 showed CC50 > 500 µM for VERO and HepG2 strains with a selectivity index greater than 12.9, a ratio calculated for P. falciparum and P. vivax regarding Vero and HepG2 cells. The compound was not considered hemolytic in in vitro assays, thus indicating the specificity of its antiplasmodial action. Based on the results presented, and considering the unprecedented character of the compound, it can be concluded that 3286938 was shown to be promising for complementary in vitro and in vivo studies aiming to produce effective antiplasmodial action." @default.
- W4318256694 created "2023-01-28" @default.
- W4318256694 creator A5023093078 @default.
- W4318256694 creator A5033556237 @default.
- W4318256694 creator A5035459344 @default.
- W4318256694 creator A5036073389 @default.
- W4318256694 creator A5051536147 @default.
- W4318256694 creator A5057155021 @default.
- W4318256694 creator A5062439943 @default.
- W4318256694 creator A5067537875 @default.
- W4318256694 creator A5073321689 @default.
- W4318256694 creator A5088352129 @default.
- W4318256694 date "2022-01-01" @default.
- W4318256694 modified "2023-09-26" @default.
- W4318256694 title "In vitro and ex vivo antiplasmodial activity of 1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one) against circulating strains of Plasmodium spp. in the state of Rondônia, Brazil" @default.
- W4318256694 cites W1541106036 @default.
- W4318256694 cites W1577683595 @default.
- W4318256694 cites W1849218084 @default.
- W4318256694 cites W1969503178 @default.
- W4318256694 cites W1973603244 @default.
- W4318256694 cites W2017165520 @default.
- W4318256694 cites W2020251171 @default.
- W4318256694 cites W2031766654 @default.
- W4318256694 cites W2036717616 @default.
- W4318256694 cites W2041704786 @default.
- W4318256694 cites W2059535228 @default.
- W4318256694 cites W2069548800 @default.
- W4318256694 cites W2070103289 @default.
- W4318256694 cites W2070868103 @default.
- W4318256694 cites W2089706810 @default.
- W4318256694 cites W2090214784 @default.
- W4318256694 cites W2096764210 @default.
- W4318256694 cites W2112893129 @default.
- W4318256694 cites W2114818342 @default.
- W4318256694 cites W2114918609 @default.
- W4318256694 cites W2118203003 @default.
- W4318256694 cites W2121049991 @default.
- W4318256694 cites W2127973996 @default.
- W4318256694 cites W2135926190 @default.
- W4318256694 cites W2149458062 @default.
- W4318256694 cites W2150471427 @default.
- W4318256694 cites W2161311583 @default.
- W4318256694 cites W2164089039 @default.
- W4318256694 cites W2164984533 @default.
- W4318256694 cites W2165198119 @default.
- W4318256694 cites W2171102256 @default.
- W4318256694 cites W2755621348 @default.
- W4318256694 cites W2793932483 @default.
- W4318256694 cites W2811326206 @default.
- W4318256694 cites W2902845685 @default.
- W4318256694 cites W3013918764 @default.
- W4318256694 doi "https://doi.org/10.1590/s2175-97902022e20453" @default.
- W4318256694 hasPublicationYear "2022" @default.
- W4318256694 type Work @default.
- W4318256694 citedByCount "0" @default.
- W4318256694 crossrefType "journal-article" @default.
- W4318256694 hasAuthorship W4318256694A5023093078 @default.
- W4318256694 hasAuthorship W4318256694A5033556237 @default.
- W4318256694 hasAuthorship W4318256694A5035459344 @default.
- W4318256694 hasAuthorship W4318256694A5036073389 @default.
- W4318256694 hasAuthorship W4318256694A5051536147 @default.
- W4318256694 hasAuthorship W4318256694A5057155021 @default.
- W4318256694 hasAuthorship W4318256694A5062439943 @default.
- W4318256694 hasAuthorship W4318256694A5067537875 @default.
- W4318256694 hasAuthorship W4318256694A5073321689 @default.
- W4318256694 hasAuthorship W4318256694A5088352129 @default.
- W4318256694 hasBestOaLocation W43182566941 @default.
- W4318256694 hasConcept C105702510 @default.
- W4318256694 hasConcept C150903083 @default.
- W4318256694 hasConcept C159047783 @default.
- W4318256694 hasConcept C185592680 @default.
- W4318256694 hasConcept C202751555 @default.
- W4318256694 hasConcept C203014093 @default.
- W4318256694 hasConcept C207001950 @default.
- W4318256694 hasConcept C26291073 @default.
- W4318256694 hasConcept C2777752497 @default.
- W4318256694 hasConcept C2778022156 @default.
- W4318256694 hasConcept C2778048844 @default.
- W4318256694 hasConcept C2778371730 @default.
- W4318256694 hasConcept C2779997623 @default.
- W4318256694 hasConcept C55493867 @default.
- W4318256694 hasConcept C71240020 @default.
- W4318256694 hasConcept C86803240 @default.
- W4318256694 hasConcept C89138240 @default.
- W4318256694 hasConcept C89423630 @default.
- W4318256694 hasConcept C98274493 @default.
- W4318256694 hasConceptScore W4318256694C105702510 @default.
- W4318256694 hasConceptScore W4318256694C150903083 @default.
- W4318256694 hasConceptScore W4318256694C159047783 @default.
- W4318256694 hasConceptScore W4318256694C185592680 @default.
- W4318256694 hasConceptScore W4318256694C202751555 @default.
- W4318256694 hasConceptScore W4318256694C203014093 @default.
- W4318256694 hasConceptScore W4318256694C207001950 @default.
- W4318256694 hasConceptScore W4318256694C26291073 @default.
- W4318256694 hasConceptScore W4318256694C2777752497 @default.
- W4318256694 hasConceptScore W4318256694C2778022156 @default.
- W4318256694 hasConceptScore W4318256694C2778048844 @default.
- W4318256694 hasConceptScore W4318256694C2778371730 @default.
- W4318256694 hasConceptScore W4318256694C2779997623 @default.
- W4318256694 hasConceptScore W4318256694C55493867 @default.