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- W4318261979 abstract "<b><i>Introduction:</i></b> We aimed to identify maternal and fetal complications and investigate postnatal and long-term outcomes of fetal hydrothorax (FHT) treated with pleuro-amniotic shunting (shunt). <b><i>Methods:</i></b> Single-center retrospective observational cohort of shunt cases performed from 2000 to 2021. Risk factors for maternal complications, fetal demise, neonatal death (NND), and postnatal outcomes were identified. <b><i>Results:</i></b> Out of 88 cases, 70 (79.5%) were complicated by hydrops, with an average gestational age (GA) at diagnosis of 27 weeks (range 16–34). In 16 cases, definitive etiology of FHT was identified; five cases of Noonan syndrome and three cases of monogenic disorders diagnosed by whole-exome sequencing (<i>EPHB4</i>, <i>VEGFR3</i>, <i>RASA1</i>). Shunt was performed at an average GA of 28 weeks (20–34), with a dislodgement in 10 cases (11.4%). <b><i>Maternal:</i></b> Complications occurred in three cases; survival rate was 76.1% (67/88). Follow-up data were available for 57/67 (85.1%) children. Incidence of severe neurodevelopmental impairment and pneumopathy (broncho dysplasia, persistent pulmonary hypertension of newborn, and asthma) was 5.3% and 8.8%, respectively. Post-treatment persistence of hydrops, FHT associated with genetic syndromes, and GA at birth were risk factors for fetal demise, NND, and postnatal complications. <b><i>Conclusion:</i></b> In truly isolated FHT, whenever indicated, pleuro-amniotic shunting is a safe procedure associated with good survival rate and long-term outcome." @default.
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- W4318261979 date "2023-01-01" @default.
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- W4318261979 title "Fetal hydrothorax treated with pleuro-amniotic shunting: fetal and maternal complication and long-term outcomes" @default.
- W4318261979 doi "https://doi.org/10.1159/000529334" @default.
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