Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318303132> ?p ?o ?g. }
- W4318303132 abstract "Abstract Altered mitochondrial function is tightly linked to lifespan regulation, but underlying mechanisms remain unclear. Here, we report the chronological and replicative lifespan variation across 168 yeast knock-out strains, each lacking a single nuclear-coded mitochondrial gene, including 144 genes with human homologs, many associated with diseases. We dissected the signatures of observed lifespan differences by analyzing profiles of each strain’s proteome, lipidome, and metabolome under fermentative and respiratory culture conditions, which correspond to the metabolic states of replicative and chronologically aging cells, respectively. Examination of the relationships among extended longevity phenotypes, protein, and metabolite levels revealed that although many of these nuclear-encoded mitochondrial genes carry out different functions, their inhibition attenuates a common mechanism that controls cytosolic ribosomal protein abundance, actin dynamics, and proteasome function to regulate lifespan. The principles of lifespan control learned through this work may be applicable to the regulation of lifespan in more complex organisms, since many aspects of mitochondrial function are highly conserved among eukaryotes." @default.
- W4318303132 created "2023-01-28" @default.
- W4318303132 creator A5002183519 @default.
- W4318303132 creator A5002586862 @default.
- W4318303132 creator A5003227044 @default.
- W4318303132 creator A5024855934 @default.
- W4318303132 creator A5027503735 @default.
- W4318303132 creator A5034175593 @default.
- W4318303132 creator A5063926161 @default.
- W4318303132 creator A5072204103 @default.
- W4318303132 creator A5072624010 @default.
- W4318303132 date "2023-01-27" @default.
- W4318303132 modified "2023-09-26" @default.
- W4318303132 title "Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespan" @default.
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