FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318305519> ?p ?o ?g. }

• W4318305519 endingPage "117235" @default.
• W4318305519 startingPage "117235" @default.
• W4318305519 abstract "Early and differential diagnosis of perihilar cholangiocarcinoma (PHCCA) is highly challenging. This study aimed to evaluate whether volatile organic compounds (VOCs) in bile samples could be emerging diagnostic biomarkers for PHCCA. We collected 200 bile samples from patients with PHCCA and benign biliary diseases (BBD), including a 140-patient training cohort and an 60-patient test cohort. Gas chromatography-ion mobility spectrometry (GC-IMS) was used for VOCs detection. The predictive models were constructed using machine learning algorithms. Our analysis detected 19 VOC substances using GC-IMS in the bile samples and resulted in the identification of three new VOCs, 2-methoxyfuran, propyl isovalerate, and diethyl malonate that were found in bile. Unsupervised hierarchical clustering analysis supported that VOCs detected in the bile could distinguish PHCCA from BBD. Twelve VOCs defined according to 32 signal peaks had significant statistical significance between BBD and PHCCA, including four up-regulated VOCs in PHCCA, such as 2-ethyl-1-hexanol, propyl isovalerate, cyclohexanone, and acetophenone, while the rest eight VOCs were down-regulated. ROC curve analysis revealed that machine learning models based on VOCs could help diagnosing PHCCA. Among them, SVM provided the highest AUC of 0·966, with a sensitivity and specificity of 93·1% and 100%, respectively. The diagnostic model based on different VOC spectra could be a feasible method for the differential diagnosis of PHCCA." @default.
• W4318305519 created "2023-01-28" @default.
• W4318305519 creator A5001969147 @default.
• W4318305519 creator A5006651636 @default.
• W4318305519 creator A5010294985 @default.
• W4318305519 creator A5024252964 @default.
• W4318305519 creator A5034783184 @default.
• W4318305519 creator A5038581532 @default.
• W4318305519 creator A5044544424 @default.
• W4318305519 creator A5070501745 @default.
• W4318305519 creator A5072453373 @default.
• W4318305519 creator A5083907893 @default.
• W4318305519 creator A5085028455 @default.
• W4318305519 creator A5085396890 @default.
• W4318305519 creator A5088313037 @default.
• W4318305519 date "2023-02-01" @default.
• W4318305519 modified "2023-10-15" @default.
• W4318305519 title "Identification and validation of volatile organic compounds in bile for differential diagnosis of perihilar cholangiocarcinoma" @default.
• W4318305519 cites W1973255896 @default.
• W4318305519 cites W2004859816 @default.
• W4318305519 cites W2007074761 @default.
• W4318305519 cites W2012811669 @default.
• W4318305519 cites W2029790242 @default.
• W4318305519 cites W2054211930 @default.
• W4318305519 cites W2054683575 @default.
• W4318305519 cites W2085134047 @default.
• W4318305519 cites W2100888621 @default.
• W4318305519 cites W2106055476 @default.
• W4318305519 cites W2110725020 @default.
• W4318305519 cites W2324977061 @default.
• W4318305519 cites W2325965936 @default.
• W4318305519 cites W2404861246 @default.
• W4318305519 cites W2526881395 @default.
• W4318305519 cites W2602206715 @default.
• W4318305519 cites W2782726279 @default.
• W4318305519 cites W2791487078 @default.
• W4318305519 cites W2793348982 @default.
• W4318305519 cites W2885919156 @default.
• W4318305519 cites W2999850615 @default.
• W4318305519 cites W3007364735 @default.
• W4318305519 cites W3026799953 @default.
• W4318305519 cites W3039360174 @default.
• W4318305519 cites W3082792235 @default.
• W4318305519 cites W3083989030 @default.
• W4318305519 cites W3087956134 @default.
• W4318305519 cites W3099626241 @default.
• W4318305519 cites W3129373151 @default.
• W4318305519 cites W3133042529 @default.
• W4318305519 cites W4211248913 @default.
• W4318305519 cites W4224095659 @default.
• W4318305519 cites W4282962154 @default.
• W4318305519 cites W4283662269 @default.
• W4318305519 doi "https://doi.org/10.1016/j.cca.2023.117235" @default.
• W4318305519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36716909" @default.
• W4318305519 hasPublicationYear "2023" @default.
• W4318305519 type Work @default.
• W4318305519 citedByCount "1" @default.
• W4318305519 crossrefType "journal-article" @default.
• W4318305519 hasAuthorship W4318305519A5001969147 @default.
• W4318305519 hasAuthorship W4318305519A5006651636 @default.
• W4318305519 hasAuthorship W4318305519A5010294985 @default.
• W4318305519 hasAuthorship W4318305519A5024252964 @default.
• W4318305519 hasAuthorship W4318305519A5034783184 @default.
• W4318305519 hasAuthorship W4318305519A5038581532 @default.
• W4318305519 hasAuthorship W4318305519A5044544424 @default.
• W4318305519 hasAuthorship W4318305519A5070501745 @default.
• W4318305519 hasAuthorship W4318305519A5072453373 @default.
• W4318305519 hasAuthorship W4318305519A5083907893 @default.
• W4318305519 hasAuthorship W4318305519A5085028455 @default.
• W4318305519 hasAuthorship W4318305519A5085396890 @default.
• W4318305519 hasAuthorship W4318305519A5088313037 @default.
• W4318305519 hasBestOaLocation W43183055191 @default.
• W4318305519 hasConcept C142724271 @default.
• W4318305519 hasConcept C162356407 @default.
• W4318305519 hasConcept C185592680 @default.
• W4318305519 hasConcept C205345274 @default.
• W4318305519 hasConcept C2775900799 @default.
• W4318305519 hasConcept C2776279336 @default.
• W4318305519 hasConcept C2779399885 @default.
• W4318305519 hasConcept C2780801072 @default.
• W4318305519 hasConcept C43617362 @default.
• W4318305519 hasConcept C55493867 @default.
• W4318305519 hasConcept C71924100 @default.
• W4318305519 hasConceptScore W4318305519C142724271 @default.
• W4318305519 hasConceptScore W4318305519C162356407 @default.
• W4318305519 hasConceptScore W4318305519C185592680 @default.
• W4318305519 hasConceptScore W4318305519C205345274 @default.
• W4318305519 hasConceptScore W4318305519C2775900799 @default.
• W4318305519 hasConceptScore W4318305519C2776279336 @default.
• W4318305519 hasConceptScore W4318305519C2779399885 @default.
• W4318305519 hasConceptScore W4318305519C2780801072 @default.
• W4318305519 hasConceptScore W4318305519C43617362 @default.
• W4318305519 hasConceptScore W4318305519C55493867 @default.
• W4318305519 hasConceptScore W4318305519C71924100 @default.
• W4318305519 hasFunder F4320321001 @default.
• W4318305519 hasFunder F4320324174 @default.
• W4318305519 hasFunder F4320329857 @default.
• W4318305519 hasLocation W43183055191 @default.

• next