FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318305546> ?p ?o ?g. }

• W4318305546 endingPage "117236" @default.
• W4318305546 startingPage "117236" @default.
• W4318305546 abstract "Breast cancer (BC) is the leading cause of cancer-related death in females. The development of non-invasive methods for the early diagnosis of BC still remains challenge. Here, we aimed to discover the urinary volatile organic compounds (VOCs) pattern of BC patients and identify potential VOC biomarkers for BC diagnosis. Urine samples were analyzed by headspace-solid phase microextraction (HS-SPME) combined with gas chromatography-high resolution mass spectrometry (GC-HRMS). To assure reliable analysis, the factors influencing HS-SPME extraction efficiency were comprehensively investigated and optimized by combing the Plackett–Burman design (PBD) with the central composite design (CCD). The established HS-SPME/GC-HRMS method was validated and applied to analyze urine samples from BC patients (n = 80) and healthy controls (n = 88). A total number of 134 VOCs belonging to distinct chemical classes were identified by GC-HRMS. BC patients demonstrated unique urinary VOCs pattern. Orthogonal partial least squares-discriminant analysis (OPLS-DA) showed a clear separation between BC patients and healthy controls. Eight potential VOC biomarkers were identified using multivariate and univariate statistical analysis. The predictive ability of candidate VOC biomarkers was further investigated by the random forest (RF) algorithm. The candidate VOC biomarkers yielded 76.3% sensitivity and 85.4% specificity on the training set, and achieved 76.0% sensitivity and 92.3% specificity on the validation set. Overall, this work not only established a standardized HS-SPME/GC-HRMS approach for urinary VOCs analysis, but also highlighted the value of urinary VOCs for BC diagnosis. The knowledge gained from this study paves the way for early diagnosis of BC using urine in a non-invasive manner." @default.
• W4318305546 created "2023-01-28" @default.
• W4318305546 creator A5017947172 @default.
• W4318305546 creator A5018161360 @default.
• W4318305546 creator A5025633927 @default.
• W4318305546 creator A5057713291 @default.
• W4318305546 creator A5061601876 @default.
• W4318305546 creator A5063123223 @default.
• W4318305546 creator A5066820530 @default.
• W4318305546 creator A5088831118 @default.
• W4318305546 date "2023-02-01" @default.
• W4318305546 modified "2023-10-16" @default.
• W4318305546 title "Development of a headspace-solid phase microextraction gas chromatography-high resolution mass spectrometry method for analyzing volatile organic compounds in urine: Application in breast cancer biomarker discovery" @default.
• W4318305546 cites W1897831097 @default.
• W4318305546 cites W1944910512 @default.
• W4318305546 cites W1968060184 @default.
• W4318305546 cites W1970711869 @default.
• W4318305546 cites W1975520205 @default.
• W4318305546 cites W1987456769 @default.
• W4318305546 cites W1987472539 @default.
• W4318305546 cites W1988694391 @default.
• W4318305546 cites W1988865632 @default.
• W4318305546 cites W1989924788 @default.
• W4318305546 cites W1991238006 @default.
• W4318305546 cites W1996791059 @default.
• W4318305546 cites W1998050847 @default.
• W4318305546 cites W1998931540 @default.
• W4318305546 cites W2003188860 @default.
• W4318305546 cites W2009612030 @default.
• W4318305546 cites W2014819189 @default.
• W4318305546 cites W2020023729 @default.
• W4318305546 cites W2023535481 @default.
• W4318305546 cites W2030633770 @default.
• W4318305546 cites W2031770401 @default.
• W4318305546 cites W2036103055 @default.
• W4318305546 cites W2040263152 @default.
• W4318305546 cites W2045235366 @default.
• W4318305546 cites W2045400248 @default.
• W4318305546 cites W2049372033 @default.
• W4318305546 cites W2058621330 @default.
• W4318305546 cites W2062833528 @default.
• W4318305546 cites W2065561581 @default.
• W4318305546 cites W2070511177 @default.
• W4318305546 cites W2072971722 @default.
• W4318305546 cites W2075989830 @default.
• W4318305546 cites W2077458096 @default.
• W4318305546 cites W2079529928 @default.
• W4318305546 cites W2089334042 @default.
• W4318305546 cites W2090354606 @default.
• W4318305546 cites W2106055476 @default.
• W4318305546 cites W2119514457 @default.
• W4318305546 cites W2125181296 @default.
• W4318305546 cites W2159731182 @default.
• W4318305546 cites W2161349624 @default.
• W4318305546 cites W2296692679 @default.
• W4318305546 cites W2322461740 @default.
• W4318305546 cites W2340888800 @default.
• W4318305546 cites W2346962909 @default.
• W4318305546 cites W2753537341 @default.
• W4318305546 cites W2801654858 @default.
• W4318305546 cites W2806441277 @default.
• W4318305546 cites W2809450463 @default.
• W4318305546 cites W2842173760 @default.
• W4318305546 cites W2884762581 @default.
• W4318305546 cites W2886135949 @default.
• W4318305546 cites W2912611062 @default.
• W4318305546 cites W2938134593 @default.
• W4318305546 cites W2978262183 @default.
• W4318305546 cites W3013596349 @default.
• W4318305546 cites W3016117755 @default.
• W4318305546 cites W3084520179 @default.
• W4318305546 cites W3094817094 @default.
• W4318305546 cites W3125891883 @default.
• W4318305546 cites W3152297894 @default.
• W4318305546 doi "https://doi.org/10.1016/j.cca.2023.117236" @default.
• W4318305546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36716910" @default.
• W4318305546 hasPublicationYear "2023" @default.
• W4318305546 type Work @default.
• W4318305546 citedByCount "1" @default.
• W4318305546 countsByYear W43183055462023 @default.
• W4318305546 crossrefType "journal-article" @default.
• W4318305546 hasAuthorship W4318305546A5017947172 @default.
• W4318305546 hasAuthorship W4318305546A5018161360 @default.
• W4318305546 hasAuthorship W4318305546A5025633927 @default.
• W4318305546 hasAuthorship W4318305546A5057713291 @default.
• W4318305546 hasAuthorship W4318305546A5061601876 @default.
• W4318305546 hasAuthorship W4318305546A5063123223 @default.
• W4318305546 hasAuthorship W4318305546A5066820530 @default.
• W4318305546 hasAuthorship W4318305546A5088831118 @default.
• W4318305546 hasConcept C105795698 @default.
• W4318305546 hasConcept C123460561 @default.
• W4318305546 hasConcept C162356407 @default.
• W4318305546 hasConcept C185592680 @default.
• W4318305546 hasConcept C205345274 @default.
• W4318305546 hasConcept C22354355 @default.
• W4318305546 hasConcept C2778533135 @default.
• W4318305546 hasConcept C2780026642 @default.
• W4318305546 hasConcept C2781197716 @default.

• next