Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318317797> ?p ?o ?g. }
- W4318317797 endingPage "111778" @default.
- W4318317797 startingPage "111778" @default.
- W4318317797 abstract "Glaucoma is a complex neurodegenerative disease of the optic nerve that leads to irreversible sight loss. Lowering intraocular pressure (IOP) medically or surgically represents the mainstay of treatment but despite adequate treatment optic nerve function can continue to deteriorate leading to blindness. There is significant clinical and experimental evidence that oxidative stress is involved in the pathogenesis of glaucoma. Decreasing the formation of lipid peroxidation products or scavenging them chemically could be beneficial in limiting the deleterious effects of oxidative stress in glaucoma. A solution to control the susceptibility of PUFAs to noxious lipid peroxidation reactions is by regioselective deuteration. Deuterium incorporated into PUFAs at bis-allylic positions (D-PUFAs) inhibits the rate-limiting step of lipid peroxidation. In this study, we have shown that Tenon’s ocular fibroblasts from glaucoma patients have significantly increased basal oxidative stress compared to non-glaucomatous control patients. Furthermore, we have shown that deuterated polyunsaturated fatty acids (D-PUFAs) provide an enhanced rescue of menadione induced lipid peroxidation in both non-glaucomatous and glaucomatous Tenon’s ocular fibroblasts using malondialdehyde (MDA) levels as a marker. Our study suggests that D-PUFAs may provide a potentially safe and effective method to reduce cytotoxic oxidative stress in glaucoma." @default.
- W4318317797 created "2023-01-28" @default.
- W4318317797 creator A5005579419 @default.
- W4318317797 creator A5043366946 @default.
- W4318317797 creator A5078690525 @default.
- W4318317797 date "2023-04-01" @default.
- W4318317797 modified "2023-10-16" @default.
- W4318317797 title "Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients" @default.
- W4318317797 cites W1891888434 @default.
- W4318317797 cites W1902672695 @default.
- W4318317797 cites W1963948646 @default.
- W4318317797 cites W1965159277 @default.
- W4318317797 cites W1969871031 @default.
- W4318317797 cites W1969939576 @default.
- W4318317797 cites W1979344831 @default.
- W4318317797 cites W1980578349 @default.
- W4318317797 cites W1986010820 @default.
- W4318317797 cites W1990249966 @default.
- W4318317797 cites W1998871738 @default.
- W4318317797 cites W2000662469 @default.
- W4318317797 cites W2003895213 @default.
- W4318317797 cites W2014218268 @default.
- W4318317797 cites W2019270582 @default.
- W4318317797 cites W2021625266 @default.
- W4318317797 cites W2027544467 @default.
- W4318317797 cites W2030251071 @default.
- W4318317797 cites W2030361580 @default.
- W4318317797 cites W2043250256 @default.
- W4318317797 cites W2044386835 @default.
- W4318317797 cites W2060035882 @default.
- W4318317797 cites W2070838021 @default.
- W4318317797 cites W2076232924 @default.
- W4318317797 cites W2076399870 @default.
- W4318317797 cites W2081202370 @default.
- W4318317797 cites W2081950356 @default.
- W4318317797 cites W2086229843 @default.
- W4318317797 cites W2089429800 @default.
- W4318317797 cites W2099020618 @default.
- W4318317797 cites W2125835148 @default.
- W4318317797 cites W2147812641 @default.
- W4318317797 cites W2148890166 @default.
- W4318317797 cites W2149989448 @default.
- W4318317797 cites W2151595915 @default.
- W4318317797 cites W2152147293 @default.
- W4318317797 cites W2160605010 @default.
- W4318317797 cites W2165249453 @default.
- W4318317797 cites W2175704762 @default.
- W4318317797 cites W2255272789 @default.
- W4318317797 cites W2316680178 @default.
- W4318317797 cites W2334991806 @default.
- W4318317797 cites W2362698467 @default.
- W4318317797 cites W2461759740 @default.
- W4318317797 cites W2508514063 @default.
- W4318317797 cites W2557667480 @default.
- W4318317797 cites W2586423373 @default.
- W4318317797 cites W2625521663 @default.
- W4318317797 cites W2774777922 @default.
- W4318317797 cites W2774809088 @default.
- W4318317797 cites W2779526889 @default.
- W4318317797 cites W2795630734 @default.
- W4318317797 cites W2799697423 @default.
- W4318317797 cites W2801494647 @default.
- W4318317797 cites W2808412572 @default.
- W4318317797 cites W2891611555 @default.
- W4318317797 cites W2900782291 @default.
- W4318317797 cites W2911634337 @default.
- W4318317797 cites W2912814233 @default.
- W4318317797 cites W2922262100 @default.
- W4318317797 cites W2943004872 @default.
- W4318317797 cites W2961283112 @default.
- W4318317797 cites W2972073820 @default.
- W4318317797 cites W2992967731 @default.
- W4318317797 cites W3006155551 @default.
- W4318317797 cites W3007726766 @default.
- W4318317797 cites W3013331699 @default.
- W4318317797 cites W3040313640 @default.
- W4318317797 cites W3080263191 @default.
- W4318317797 cites W3085911010 @default.
- W4318317797 cites W3115251192 @default.
- W4318317797 cites W3131697812 @default.
- W4318317797 cites W3173654426 @default.
- W4318317797 cites W3181573421 @default.
- W4318317797 cites W3198861257 @default.
- W4318317797 cites W580600975 @default.
- W4318317797 doi "https://doi.org/10.1016/j.mad.2023.111778" @default.
- W4318317797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36716826" @default.
- W4318317797 hasPublicationYear "2023" @default.
- W4318317797 type Work @default.
- W4318317797 citedByCount "0" @default.
- W4318317797 crossrefType "journal-article" @default.
- W4318317797 hasAuthorship W4318317797A5005579419 @default.
- W4318317797 hasAuthorship W4318317797A5043366946 @default.
- W4318317797 hasAuthorship W4318317797A5078690525 @default.
- W4318317797 hasBestOaLocation W43183177971 @default.
- W4318317797 hasConcept C118487528 @default.
- W4318317797 hasConcept C126322002 @default.
- W4318317797 hasConcept C185592680 @default.
- W4318317797 hasConcept C19038510 @default.