Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318385195> ?p ?o ?g. }
- W4318385195 abstract "Abstract Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. To improve our understanding of the genetics of PAU, we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals. We observed a high degree of cross-ancestral similarity in the genetic architecture of PAU and identified 110 independent risk variants in within- and cross-ancestry analyses. Cross-ancestry fine-mapping improved the identification of likely causal variants. Prioritizing genes through gene expression and/or chromatin interaction in brain tissues identified multiple genes associated with PAU. We identified existing medications for potential pharmacological studies by drug repurposing analysis. Cross-ancestry polygenic risk scores (PRS) showed better performance in independent sample than single-ancestry PRS. Genetic correlations between PAU and other traits were observed in multiple ancestries, with other substance use traits having the highest correlations. The analysis of diverse ancestries contributed significantly to the findings, and fills an important gap in the literature." @default.
- W4318385195 created "2023-01-29" @default.
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- W4318385195 date "2023-01-28" @default.
- W4318385195 modified "2023-10-12" @default.
- W4318385195 title "Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals" @default.
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- W4318385195 cites W2510973425 @default.
- W4318385195 cites W2529241974 @default.
- W4318385195 cites W2581490583 @default.
- W4318385195 cites W2612467560 @default.
- W4318385195 cites W2622753418 @default.
- W4318385195 cites W2749491127 @default.
- W4318385195 cites W2755612616 @default.
- W4318385195 cites W2759086237 @default.
- W4318385195 cites W2761275051 @default.
- W4318385195 cites W2770092353 @default.
- W4318385195 cites W2790535666 @default.
- W4318385195 cites W2791854743 @default.
- W4318385195 cites W2792167682 @default.
- W4318385195 cites W2895486342 @default.
- W4318385195 cites W2909598358 @default.
- W4318385195 cites W2928966425 @default.
- W4318385195 cites W2933424604 @default.
- W4318385195 cites W2945005138 @default.
- W4318385195 cites W2950099124 @default.
- W4318385195 cites W2950598813 @default.
- W4318385195 cites W2950625872 @default.