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• W4318391884 abstract "Abstract Aim To evaluate whether pregnancy and birth‐related factors are associated with celiac disease (CD) in a large, United States (US)‐based mother‐child cohort. Methods We analysed data gathering from the Massachusetts General Hospital Maternal Child Cohort (MMCC) of children born between 1998 and 2016. Data included the mode of delivery, maternal pregnancy and their offspring characteristics. We searched for CD cases by using diagnosis billing codes. Cox proportional hazard regression models were created to identify variables associated with CD. Results We identified 44 539 mother‐child pairs who had at least one encounter by 5 years old and identified 173 children (0.4%) with CD diagnosis; median age at the diagnosis was 6 years. Overall, the adjusted hazard ratio (aHR) of caesarean delivery for CD was 1.39 (95% CI: 0.99, 1.96, p = 0.06) when compared to children born vaginally. After stratifying for the presence of labour, children born by Caesarean delivery without labour had a higher risk of CD (aHR 1.56; 95%CI: 1.01, 2.41; p = 0.046) while infants born by Caesarean delivery with labour did not (aHR 1.26; 95% CI: 0.83, 1.93; p = 0.28). Conclusion Being born by Caesarean delivery without labour may be associated with an increased risk for CD in the US children." @default.
• W4318391884 created "2023-01-29" @default.
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• W4318391884 date "2023-02-07" @default.
• W4318391884 modified "2023-09-26" @default.
• W4318391884 title "Pregnancy‐ and birth‐related risk factors for the development of childhood celiac disease" @default.
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• W4318391884 doi "https://doi.org/10.1111/apa.16686" @default.
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