FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318392020> ?p ?o ?g. }

• W4318392020 endingPage "123412" @default.
• W4318392020 startingPage "123412" @default.
• W4318392020 abstract "Disruption of cellular homeostasis by the aggregation of polyglutamine (polyQ) in the huntingtin protein (Htt) leads Huntington's disease (HD). Effective drugs for treating HD have not been developed, as the molecular mechanism underlying HD pathogenesis remains unclear. To develop strategies for inhibiting HD pathogenesis, the intermolecular interaction of Htt with IP3 receptor 1 (IP3R1) was investigated. Peptide (termed ICT60) corresponding to a coiled-coil motif in the C-terminus of IP3R1 was designed. Several biophysical approaches revealed the strong and specific binding of ICT60 to the N-terminal part of HttEx1. ICT60 inhibited not only amyloid formation by HttEx1, but also the cytotoxicity and cell-penetration ability of the amyloid fibrils of HttEx1. The importance of coiled-coil structure was verified by charge-manipulated variants. The coiled-coil structures of ICT60-KK and -EE were partially and largely disrupted, respectively. ICT60 wild-type and -KK inhibited amyloid formation by HttEx1-46Q, whereas ICT60-EE did not block amyloidogenesis. Similarly, the cytotoxicity and cell-penetration ability of the amyloid fibrils of HttEx1-46Q were efficiently inhibited by ICT60 wild-type and ICT60-KK, but not by ICT60-EE. We propose a mechanical model explaining how an IP3 receptor-inspired molecule can modulate cytotoxic amyloid formation by Htt, providing a molecular basis for developing therapeutics to treat HD." @default.
• W4318392020 created "2023-01-29" @default.
• W4318392020 creator A5006220130 @default.
• W4318392020 creator A5022053152 @default.
• W4318392020 creator A5022508758 @default.
• W4318392020 creator A5023480923 @default.
• W4318392020 creator A5031870659 @default.
• W4318392020 creator A5037745505 @default.
• W4318392020 creator A5037895785 @default.
• W4318392020 creator A5065184841 @default.
• W4318392020 creator A5075014441 @default.
• W4318392020 creator A5076130268 @default.
• W4318392020 creator A5078652028 @default.
• W4318392020 date "2023-03-01" @default.
• W4318392020 modified "2023-10-17" @default.
• W4318392020 title "Coiled-coil structure mediated inhibition of the cytotoxic huntingtin amyloid fibrils by an IP3 receptor fragment" @default.
• W4318392020 cites W1978677176 @default.
• W4318392020 cites W1982138826 @default.
• W4318392020 cites W1985474993 @default.
• W4318392020 cites W1994947657 @default.
• W4318392020 cites W2031280902 @default.
• W4318392020 cites W2034963123 @default.
• W4318392020 cites W2042567578 @default.
• W4318392020 cites W2057673048 @default.
• W4318392020 cites W2060354977 @default.
• W4318392020 cites W2082176639 @default.
• W4318392020 cites W2098123284 @default.
• W4318392020 cites W2125054419 @default.
• W4318392020 cites W2132629607 @default.
• W4318392020 cites W2141583055 @default.
• W4318392020 cites W2144535585 @default.
• W4318392020 cites W2146488942 @default.
• W4318392020 cites W2153807318 @default.
• W4318392020 cites W2154778779 @default.
• W4318392020 cites W2169821755 @default.
• W4318392020 cites W2170564629 @default.
• W4318392020 cites W2171778773 @default.
• W4318392020 cites W2173669563 @default.
• W4318392020 cites W2332078368 @default.
• W4318392020 cites W2516126943 @default.
• W4318392020 cites W2588443411 @default.
• W4318392020 cites W2618334148 @default.
• W4318392020 cites W2745482791 @default.
• W4318392020 cites W2890108523 @default.
• W4318392020 cites W2916640091 @default.
• W4318392020 cites W2998004872 @default.
• W4318392020 cites W3023529422 @default.
• W4318392020 cites W56410776 @default.
• W4318392020 doi "https://doi.org/10.1016/j.ijbiomac.2023.123412" @default.
• W4318392020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36706883" @default.
• W4318392020 hasPublicationYear "2023" @default.
• W4318392020 type Work @default.
• W4318392020 citedByCount "1" @default.
• W4318392020 countsByYear W43183920202023 @default.
• W4318392020 crossrefType "journal-article" @default.
• W4318392020 hasAuthorship W4318392020A5006220130 @default.
• W4318392020 hasAuthorship W4318392020A5022053152 @default.
• W4318392020 hasAuthorship W4318392020A5022508758 @default.
• W4318392020 hasAuthorship W4318392020A5023480923 @default.
• W4318392020 hasAuthorship W4318392020A5031870659 @default.
• W4318392020 hasAuthorship W4318392020A5037745505 @default.
• W4318392020 hasAuthorship W4318392020A5037895785 @default.
• W4318392020 hasAuthorship W4318392020A5065184841 @default.
• W4318392020 hasAuthorship W4318392020A5075014441 @default.
• W4318392020 hasAuthorship W4318392020A5076130268 @default.
• W4318392020 hasAuthorship W4318392020A5078652028 @default.
• W4318392020 hasConcept C104317684 @default.
• W4318392020 hasConcept C109316439 @default.
• W4318392020 hasConcept C12554922 @default.
• W4318392020 hasConcept C143065580 @default.
• W4318392020 hasConcept C170493617 @default.
• W4318392020 hasConcept C179104552 @default.
• W4318392020 hasConcept C185592680 @default.
• W4318392020 hasConcept C202751555 @default.
• W4318392020 hasConcept C203014093 @default.
• W4318392020 hasConcept C27523624 @default.
• W4318392020 hasConcept C2777633098 @default.
• W4318392020 hasConcept C2779281246 @default.
• W4318392020 hasConcept C2780942790 @default.
• W4318392020 hasConcept C2781427258 @default.
• W4318392020 hasConcept C55493867 @default.
• W4318392020 hasConcept C55988834 @default.
• W4318392020 hasConcept C86803240 @default.
• W4318392020 hasConcept C95444343 @default.
• W4318392020 hasConceptScore W4318392020C104317684 @default.
• W4318392020 hasConceptScore W4318392020C109316439 @default.
• W4318392020 hasConceptScore W4318392020C12554922 @default.
• W4318392020 hasConceptScore W4318392020C143065580 @default.
• W4318392020 hasConceptScore W4318392020C170493617 @default.
• W4318392020 hasConceptScore W4318392020C179104552 @default.
• W4318392020 hasConceptScore W4318392020C185592680 @default.
• W4318392020 hasConceptScore W4318392020C202751555 @default.
• W4318392020 hasConceptScore W4318392020C203014093 @default.
• W4318392020 hasConceptScore W4318392020C27523624 @default.
• W4318392020 hasConceptScore W4318392020C2777633098 @default.
• W4318392020 hasConceptScore W4318392020C2779281246 @default.
• W4318392020 hasConceptScore W4318392020C2780942790 @default.
• W4318392020 hasConceptScore W4318392020C2781427258 @default.

• next