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- W4318422910 abstract "This chapter deals with the use of transition metals and enzymes in tandem for achieving DKR. This powerful concept has widely extended the scope of DKRs. Three major types of enzyme-metal combinations, lipase-ruthenium, subtilisin-ruthenium, and lipase combined with a metal other than ruthenium, have been developed as the catalysts for the DKRs of various secondary alcohols but also for diols, amines, and esters. Meanwhile, the lipase-ruthenium combination has been the most used method so far. In the case of DKR of alcohols, complementary catalyst systems are now available for the synthesis of both (R)- and (S)-esters. Thus, (R)-esters can be obtained by the combination of an R-selective lipase, such as CAL-B or LPS, and a racemisation catalyst, whereas the use of an S-selective protease, such as subtilisin, provides (S)-esters. The DKR of alcohols can be achieved not only for simple alcohols but also for those bearing various additional functional groups. The DKR of alcohols has also been applied to the synthesis of chiral polymers and coupled to tandem reactions, producing various polycyclic compounds. Today, a number of robust, reusable racemisation catalysts are available, which are stable even under aerobic conditions. Palladium nanoparticles embedded on various supports are common catalysts for amine racemisation, although there are some other catalysts, such as Raney nickel and Shvo-type ruthenium complexes. The DKR of amines is possible for aliphatic amines as well as for benzylic ones. Moreover, the DKR of amino acid derivatives has also been successfully developed." @default.
- W4318422910 created "2023-01-29" @default.
- W4318422910 date "2011-04-04" @default.
- W4318422910 modified "2023-09-24" @default.
- W4318422910 title "Use of Transition Metals and Enzymes in Tandem" @default.
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