FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318442914> ?p ?o ?g. }

• W4318442914 abstract "The association between dietary antioxidants and asthma or exercise-induced bronchoconstriction (EIB) is not fully understood. Vitamin C and vitamin E are natural antioxidants that are predominantly present in fruits and vegetables; inadequate vitamin E intake is associated with airway inflammation. It has been postulated that the combination may be more beneficial than either single antioxidant for people with asthma and exercise-induced bronchoconstriction.To assess the effects of supplementation of vitamins C and E versus placebo (or no vitamin C and E supplementation) on exacerbations and health-related quality of life (HRQL) in adults and children with chronic asthma. To also examine the potential effects of vitamins C and E on exercise-induced bronchoconstriction in people with asthma and in people without a diagnosis of asthma who experience symptoms only on exercise.Trials were identified from the Cochrane Airways Review Group Specialised Register and from trial registry websites. Searches were conducted in September 2013.We included randomised controlled trials of adults and children with a diagnosis of asthma. We separately considered trials in which participants had received a diagnosis of exercise-induced bronchoconstriction (or exercise-induced asthma). Trials comparing vitamin C and E supplementation versus placebo were included. We included trials in which asthma management for treatment and control groups included similar background therapy. Short-term use of vitamins C and E at the time of exacerbation or for cold symptoms in people with asthma is outside the scope of this review.Two review authors independently screened the titles and abstracts of potential studies and subsequently screened full-text study reports for inclusion. We used standard methods as expected by The Cochrane Collaboration.It was not possible to aggregate the five included studies (214 participants). Four studies (206 participants) addressed the question of whether differences in outcomes were seen when vitamin C and E supplementation versus placebo was provided for participants with asthma, and only one of those studies (160 children) included a paediatric population; the remaining three studies included a combined total of just 46 adults. An additional study considered the question of whether differences in outcomes were noted when vitamin C and E supplementation was compared with placebo for exercise-induced asthma; this trial included only eight participants. The randomisation process of the trials were unclear leading us to downgrade the quality of the evidence. Four of the studies were double blind while the other study was single blind.None of these studies provided data on our two prespecified primary outcome measures: exacerbations and HRQL. Lung function data obtained from the studies were inconclusive. The only studies that provided any suggestion of an effect, and only with some outcomes, were the paediatric study, especially for children with moderate to severe asthma, and the small study on exercise-induced asthma. Even so, this evidence was judged to be at moderate/low quality. Only one study contributed data on asthma symptoms and adverse events, reporting no evidence of an effect of the intervention for symptoms and that one participant in the treatment group dropped out due to cystitis.It is not possible to draw firm conclusions from this review with respect to the comparison of vitamin C and E supplementation versus placebo in the management of asthma or exercise-induced bronchoconstriction. We found only one study relevant to exercise-induced bronchoconstriction; most included participants came from studies designed to assess the effect of vitamin supplementation on the impact of atmospheric pollutants (such as ozone). Evidence is lacking on the comparison of vitamin C and E supplementation versus placebo for asthma with respect to outcomes such as HRQL and exacerbations, which were not addressed by any of the included studies.When compared with lung function tests alone, HRQL scores and exacerbation frequency are better indicators of the severity of asthma, its impact on daily activities and its response to treatment in a patient population. These end points are well recognised in good quality studies of asthma management. However, clinical studies of vitamins C and E in the management of asthma using these important end points of exacerbations and effects on quality of life are not available, and evidence is insufficient to support robust conclusions on the role of vitamin C and E supplementation in asthma and exercise-induced breathlessness." @default.
• W4318442914 created "2023-01-30" @default.
• W4318442914 creator A5027169335 @default.
• W4318442914 creator A5037509074 @default.
• W4318442914 creator A5067612976 @default.
• W4318442914 creator A5076740398 @default.
• W4318442914 date "2014-06-17" @default.
• W4318442914 modified "2023-10-17" @default.
• W4318442914 title "Vitamins C and E for asthma and exercise-induced bronchoconstriction" @default.
• W4318442914 cites W106162916 @default.
• W4318442914 cites W12386885 @default.
• W4318442914 cites W1528631957 @default.
• W4318442914 cites W1701517268 @default.
• W4318442914 cites W1752209030 @default.
• W4318442914 cites W1890770975 @default.
• W4318442914 cites W1892517012 @default.
• W4318442914 cites W1963797394 @default.
• W4318442914 cites W1969603189 @default.
• W4318442914 cites W1970001512 @default.
• W4318442914 cites W1972614126 @default.
• W4318442914 cites W1980505425 @default.
• W4318442914 cites W1983658955 @default.
• W4318442914 cites W1984979375 @default.
• W4318442914 cites W1985440102 @default.
• W4318442914 cites W1996786830 @default.
• W4318442914 cites W1997434073 @default.
• W4318442914 cites W1997673087 @default.
• W4318442914 cites W1997681241 @default.
• W4318442914 cites W1999886464 @default.
• W4318442914 cites W2000411020 @default.
• W4318442914 cites W200347496 @default.
• W4318442914 cites W2003881457 @default.
• W4318442914 cites W2004735228 @default.
• W4318442914 cites W2010248946 @default.
• W4318442914 cites W2018463247 @default.
• W4318442914 cites W2025038323 @default.
• W4318442914 cites W2025062356 @default.
• W4318442914 cites W2026821754 @default.
• W4318442914 cites W2026953501 @default.
• W4318442914 cites W2028607481 @default.
• W4318442914 cites W2035362329 @default.
• W4318442914 cites W2038061945 @default.
• W4318442914 cites W2040421703 @default.
• W4318442914 cites W2041721448 @default.
• W4318442914 cites W2042317364 @default.
• W4318442914 cites W2046954536 @default.
• W4318442914 cites W2048520233 @default.
• W4318442914 cites W2049539896 @default.
• W4318442914 cites W2050747371 @default.
• W4318442914 cites W2051691177 @default.
• W4318442914 cites W2054197933 @default.
• W4318442914 cites W2058715299 @default.
• W4318442914 cites W2065572304 @default.
• W4318442914 cites W2072327290 @default.
• W4318442914 cites W2074147355 @default.
• W4318442914 cites W2079791813 @default.
• W4318442914 cites W2082861687 @default.
• W4318442914 cites W2084487755 @default.
• W4318442914 cites W2094967860 @default.
• W4318442914 cites W2095693670 @default.
• W4318442914 cites W2097005998 @default.
• W4318442914 cites W2110921365 @default.
• W4318442914 cites W2111397989 @default.
• W4318442914 cites W2114780443 @default.
• W4318442914 cites W2117288291 @default.
• W4318442914 cites W2119218824 @default.
• W4318442914 cites W2119449792 @default.
• W4318442914 cites W2119544188 @default.
• W4318442914 cites W2122820236 @default.
• W4318442914 cites W2126723541 @default.
• W4318442914 cites W2127584048 @default.
• W4318442914 cites W2128373399 @default.
• W4318442914 cites W2128432116 @default.
• W4318442914 cites W2128941372 @default.
• W4318442914 cites W2130949502 @default.
• W4318442914 cites W2133452564 @default.
• W4318442914 cites W2133835743 @default.
• W4318442914 cites W2133969649 @default.
• W4318442914 cites W2135432052 @default.
• W4318442914 cites W2138766578 @default.
• W4318442914 cites W2142937214 @default.
• W4318442914 cites W2146537969 @default.
• W4318442914 cites W2146602405 @default.
• W4318442914 cites W2146988265 @default.
• W4318442914 cites W2147686766 @default.
• W4318442914 cites W2148260177 @default.
• W4318442914 cites W2148583214 @default.
• W4318442914 cites W2148994344 @default.
• W4318442914 cites W2151197017 @default.
• W4318442914 cites W2152410180 @default.
• W4318442914 cites W2152612544 @default.
• W4318442914 cites W2153816809 @default.
• W4318442914 cites W2161450363 @default.
• W4318442914 cites W2163785734 @default.
• W4318442914 cites W2164191624 @default.
• W4318442914 cites W2167698267 @default.
• W4318442914 cites W2171663074 @default.
• W4318442914 cites W2172417300 @default.
• W4318442914 cites W2258263699 @default.
• W4318442914 cites W2293756780 @default.

• next