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• W4318442959 endingPage "81" @default.
• W4318442959 startingPage "73" @default.
• W4318442959 abstract "Rotavirus vaccines were first introduced more than a decade ago and have had a tremendous impact on reducing the number of hospitalizations and deaths due to rotavirus-associated diarrhea. This review will discuss current rotavirus vaccines, post-licensure surveillance, progress in non-replicating vaccine development, and why continued research is important for understanding a virus that remains a globally leading cause of death due to diarrhea. Research advances have enhanced our understanding of how vaccines induce protection against subsequent severe disease, how the virus replicates and spreads in the face of the host immune system, and basic mechanisms governing the viral life cycle. Much remains to be learned about how to improve vaccine success, what the molecular determinants of host range and virulence are, and what the interactions of the virus with the host are that drive its replicative success, among many other important questions." @default.
• W4318442959 created "2023-01-30" @default.
• W4318442959 creator A5061434963 @default.
• W4318442959 date "2018-01-18" @default.
• W4318442959 modified "2023-10-11" @default.
• W4318442959 title "Rotavirus Vaccines: Why Continued Investment in Research Is Necessary" @default.
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