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- W4318443289 abstract "Δ9-Tetrahydrocannabinol (Δ9-THC) inhibits pituitary gonadotropin secretion in castrated rhesus monkeys. Also, Δ9-THC blocks the ovulatory reflux in rabbits. We report now the dose-response relationship of precoital single doses of Δ9-THC on luteinizing hormone (LH) release and ovulation in the rabbit. Forty-five female rabbits in estrous were divided into nine groups of five animals. Groups 1 to 5 received a single intramuscular dose of Δ9-THC (5, 2.5, 1.25, 0.612, and 0.306 mg/kg, respectively) 2 hours before mating; animals of group 6 received vehicle only. In animals of groups 7 and 8 ovulation was induced with 100 IU of human chorionic gonadotropic (hCG), given intravenously 2 hours after the administration of Δ9-THC (5 mg/kg) or vehicle. Rabbit luteinizing hormone (rLH) was measured in plasma 90 to 120 minutes after coitus or hCG administration. After the injection of 5 mg of Δ9-THC, luteinizing hormone-releasing factor (LH-RF) (20 μg intravenously) was administered to the animals of group 9. All animals of groups 6, 7, and 8 ovulated. A dose-response curve was observed in the animals treated with Δ9-THC and natural mating. Whereas none of the animals treated with 5 or 2.5 mg/kg ovulated, one of the group treated with 1.25 mg/kg, two of the group treated with 0.612 mg/kg, and all treated with 0.312 mg/kg ovulated. Ovulations correlated with postcoital levels of rLH. All animals of group 9 ovulated, indicating that the site of action of Δ9-THC is suprapituitary, probably hypothalamic." @default.
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- W4318443289 date "1979-03-01" @default.
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- W4318443289 title "Precoital Single Doses of Δ9-Tetrahydrocannabinol Block Ovulation in the Rabbit" @default.
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- W4318443289 doi "https://doi.org/10.1016/s0015-0282(16)43884-7" @default.
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