Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318464502> ?p ?o ?g. }
- W4318464502 endingPage "121458" @default.
- W4318464502 startingPage "121458" @default.
- W4318464502 abstract "Cancer metastasis is the major cause of cancer-related deaths. There are few prior studies reported on molecules targeting C-X-C chemokine receptor (CXCR) family and manganese superoxide dismutase (MnSOD). CXCRs are known to involve in angiogenesis, metastasis, cell survival and MnSOD is reported to be related in Epithelial–mesenchymal transition (EMT). Cell viability and cell proliferation were measured by MTT and BrdU assay. Protein expression level of CXCR4/7, MMP-2/9, MnSOD, and EMT markers were evaluated by Western blot analysis. mRNA levels of Snail and Occludin were analyzed by Real-time RT-qPCR. Expression of EMT markers in cells was observed by immunocytochemistry. Cell invasion and migrations were evaluated by wound healing assay and boyden chamber assay. We noticed that LGA abolished proliferation, invasive ability, and cellular migration. LGA down-regulated the protein levels of mesenchymal markers such as Twist, Snail, Fibronectin, and Vimentin in CXCL12-treated HCC cells. It also suppressed the gelatinolytic activity of MMP-9/2. The amplification of MnSOD increased EMT-like phenotypes but with LGA treatment, these phenotypes were markedly attenuated. The overexpression of MnSOD increased the ROS levels significantly but ROS levels were decreased upon exposure to LGA and deletion of MnSOD suppressed the levels of various mesenchymal proteins. LGA could function as a novel anti-metastatic agent by suppressing metastasis and EMT process via attenuation of MnSOD expression in hepatocellular carcinoma cells." @default.
- W4318464502 created "2023-01-30" @default.
- W4318464502 creator A5034304968 @default.
- W4318464502 creator A5037236595 @default.
- W4318464502 creator A5040923950 @default.
- W4318464502 creator A5056250867 @default.
- W4318464502 creator A5058193427 @default.
- W4318464502 creator A5072393058 @default.
- W4318464502 date "2023-03-01" @default.
- W4318464502 modified "2023-09-27" @default.
- W4318464502 title "Loganic acid regulates the transition between epithelial and mesenchymal-like phenotypes by alleviating MnSOD expression in hepatocellular carcinoma cells" @default.
- W4318464502 cites W1580798788 @default.
- W4318464502 cites W1597259801 @default.
- W4318464502 cites W1969737102 @default.
- W4318464502 cites W1995072944 @default.
- W4318464502 cites W1997684038 @default.
- W4318464502 cites W2044237843 @default.
- W4318464502 cites W2101547995 @default.
- W4318464502 cites W2107955209 @default.
- W4318464502 cites W2110842318 @default.
- W4318464502 cites W2127008679 @default.
- W4318464502 cites W2156323704 @default.
- W4318464502 cites W2161162542 @default.
- W4318464502 cites W2418657666 @default.
- W4318464502 cites W2467354752 @default.
- W4318464502 cites W2470393920 @default.
- W4318464502 cites W2490891607 @default.
- W4318464502 cites W2504338811 @default.
- W4318464502 cites W2529157745 @default.
- W4318464502 cites W2589094768 @default.
- W4318464502 cites W2622742041 @default.
- W4318464502 cites W2767676275 @default.
- W4318464502 cites W2797069917 @default.
- W4318464502 cites W2800067719 @default.
- W4318464502 cites W2810681792 @default.
- W4318464502 cites W2849897828 @default.
- W4318464502 cites W2918297277 @default.
- W4318464502 cites W2982132972 @default.
- W4318464502 cites W2982144026 @default.
- W4318464502 cites W2982439214 @default.
- W4318464502 cites W3000919165 @default.
- W4318464502 cites W3004641930 @default.
- W4318464502 cites W3026103712 @default.
- W4318464502 cites W3027883869 @default.
- W4318464502 cites W3033738814 @default.
- W4318464502 cites W3039879681 @default.
- W4318464502 cites W3041026090 @default.
- W4318464502 cites W3095107406 @default.
- W4318464502 cites W3109617916 @default.
- W4318464502 cites W3120912370 @default.
- W4318464502 cites W3136780745 @default.
- W4318464502 cites W3137422871 @default.
- W4318464502 cites W3158357432 @default.
- W4318464502 cites W3164141713 @default.
- W4318464502 cites W3183684921 @default.
- W4318464502 cites W3196417022 @default.
- W4318464502 cites W3212182989 @default.
- W4318464502 cites W3217289739 @default.
- W4318464502 cites W4200235168 @default.
- W4318464502 cites W4212947535 @default.
- W4318464502 cites W4220855448 @default.
- W4318464502 cites W4280544607 @default.
- W4318464502 cites W4281707807 @default.
- W4318464502 cites W4281767770 @default.
- W4318464502 cites W4282007782 @default.
- W4318464502 cites W4283456247 @default.
- W4318464502 cites W4289778924 @default.
- W4318464502 cites W4292800541 @default.
- W4318464502 cites W4293773340 @default.
- W4318464502 cites W4294992918 @default.
- W4318464502 cites W4295107359 @default.
- W4318464502 doi "https://doi.org/10.1016/j.lfs.2023.121458" @default.
- W4318464502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36731649" @default.
- W4318464502 hasPublicationYear "2023" @default.
- W4318464502 type Work @default.
- W4318464502 citedByCount "0" @default.
- W4318464502 crossrefType "journal-article" @default.
- W4318464502 hasAuthorship W4318464502A5034304968 @default.
- W4318464502 hasAuthorship W4318464502A5037236595 @default.
- W4318464502 hasAuthorship W4318464502A5040923950 @default.
- W4318464502 hasAuthorship W4318464502A5056250867 @default.
- W4318464502 hasAuthorship W4318464502A5058193427 @default.
- W4318464502 hasAuthorship W4318464502A5072393058 @default.
- W4318464502 hasConcept C121608353 @default.
- W4318464502 hasConcept C137738243 @default.
- W4318464502 hasConcept C142724271 @default.
- W4318464502 hasConcept C147447768 @default.
- W4318464502 hasConcept C1491633281 @default.
- W4318464502 hasConcept C153911025 @default.
- W4318464502 hasConcept C198826908 @default.
- W4318464502 hasConcept C203014093 @default.
- W4318464502 hasConcept C204232928 @default.
- W4318464502 hasConcept C2779013556 @default.
- W4318464502 hasConcept C2780269544 @default.
- W4318464502 hasConcept C502942594 @default.
- W4318464502 hasConcept C54355233 @default.
- W4318464502 hasConcept C71924100 @default.
- W4318464502 hasConcept C76419328 @default.