Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318473003> ?p ?o ?g. }
- W4318473003 endingPage "235" @default.
- W4318473003 startingPage "201" @default.
- W4318473003 abstract "Gallbladder carcinoma (GBC) is among the most malignant neoplasms of the biliary tract with poor prognosis and reduced survival rates in different geographic locations of the world. Various risk factors, including gall stone, obesity, dietary habit, bacterial (e.g., H. pylori) infection, etc., are proposed but we are still unaware of a definite or specific causative factor. Most patients present for treatment with an advanced and inoperable state where the effect of conventional therapy becomes limiting or ineffective. Studies on the molecular pathology of GBC indicated numerous known genetic and epigenetic impairments responsible, but the exact mechanism of gallbladder cancer is yet to be revealed. With the advent of latest technology, investigations are continued to identify suitable biomarkers appropriate for early diagnosis and prognosis of GBC. This review provides an overview of the epigenetic mechanisms associated with gallbladder carcinoma, such as DNA methylation, histone modifications, and the role of non-coding RNAs. The non-coding RNAs (e.g., microRNAs, long non-coding RNAs, and circular RNAs) play significant role, directly or indirectly, in the transcriptional regulation of cancer associated target genes. It also includes brief description of the implications of promising epigenetic biomarkers (both coding and non-coding), identified in tissue samples or in circulating body fluids, in early detection, diagnosis and or prognosis of gallbladder cancer. The review has particularly discussed the concept of epigenetically targeted therapy, emphasizing the prospects of targeting some of the commonly identified cancer biomarkers, currently under preclinical or clinical investigations in other cancers, in the treatment of gallbladder cancer." @default.
- W4318473003 created "2023-01-30" @default.
- W4318473003 creator A5023527511 @default.
- W4318473003 creator A5045515571 @default.
- W4318473003 creator A5078022529 @default.
- W4318473003 date "2023-01-01" @default.
- W4318473003 modified "2023-10-15" @default.
- W4318473003 title "Gallbladder Cancer: Epigenetic Landscape, Targeted Therapy, and Prospect of Epitherapy" @default.
- W4318473003 cites W144423133 @default.
- W4318473003 cites W1484293540 @default.
- W4318473003 cites W1519739419 @default.
- W4318473003 cites W1525943439 @default.
- W4318473003 cites W1550216977 @default.
- W4318473003 cites W1577520625 @default.
- W4318473003 cites W1589575052 @default.
- W4318473003 cites W1603797292 @default.
- W4318473003 cites W1635672209 @default.
- W4318473003 cites W1648301895 @default.
- W4318473003 cites W1710716389 @default.
- W4318473003 cites W1751718048 @default.
- W4318473003 cites W1823362496 @default.
- W4318473003 cites W1825741660 @default.
- W4318473003 cites W1831299015 @default.
- W4318473003 cites W1843651808 @default.
- W4318473003 cites W1851820790 @default.
- W4318473003 cites W190848849 @default.
- W4318473003 cites W1969485334 @default.
- W4318473003 cites W1970287742 @default.
- W4318473003 cites W1972739162 @default.
- W4318473003 cites W1977083846 @default.
- W4318473003 cites W1978605779 @default.
- W4318473003 cites W1979206745 @default.
- W4318473003 cites W1980131884 @default.
- W4318473003 cites W1980826276 @default.
- W4318473003 cites W1980915468 @default.
- W4318473003 cites W1981364314 @default.
- W4318473003 cites W1988142400 @default.
- W4318473003 cites W1988492454 @default.
- W4318473003 cites W1991154912 @default.
- W4318473003 cites W1993211000 @default.
- W4318473003 cites W1994548165 @default.
- W4318473003 cites W1997232290 @default.
- W4318473003 cites W1999155891 @default.
- W4318473003 cites W1999504198 @default.
- W4318473003 cites W1999825155 @default.
- W4318473003 cites W1999952393 @default.
- W4318473003 cites W2000156285 @default.
- W4318473003 cites W2004380688 @default.
- W4318473003 cites W2005202092 @default.
- W4318473003 cites W2010732143 @default.
- W4318473003 cites W2011904430 @default.
- W4318473003 cites W2013154874 @default.
- W4318473003 cites W2013577132 @default.
- W4318473003 cites W2014946489 @default.
- W4318473003 cites W2015052870 @default.
- W4318473003 cites W2017394727 @default.
- W4318473003 cites W2021221404 @default.
- W4318473003 cites W2021424812 @default.
- W4318473003 cites W2022143863 @default.
- W4318473003 cites W2024502310 @default.
- W4318473003 cites W2029463176 @default.
- W4318473003 cites W2030712838 @default.
- W4318473003 cites W2031880275 @default.
- W4318473003 cites W2031896201 @default.
- W4318473003 cites W2035772974 @default.
- W4318473003 cites W2036986058 @default.
- W4318473003 cites W2040257851 @default.
- W4318473003 cites W2041535798 @default.
- W4318473003 cites W2044303805 @default.
- W4318473003 cites W2044314921 @default.
- W4318473003 cites W2045477218 @default.
- W4318473003 cites W2046873991 @default.
- W4318473003 cites W2048917470 @default.
- W4318473003 cites W2049563334 @default.
- W4318473003 cites W2055191970 @default.
- W4318473003 cites W2056780782 @default.
- W4318473003 cites W2057023729 @default.
- W4318473003 cites W2058815850 @default.
- W4318473003 cites W2062110561 @default.
- W4318473003 cites W2062421371 @default.
- W4318473003 cites W206344101 @default.
- W4318473003 cites W2065588058 @default.
- W4318473003 cites W2066523389 @default.
- W4318473003 cites W2068088523 @default.
- W4318473003 cites W2068622871 @default.
- W4318473003 cites W2070777085 @default.
- W4318473003 cites W2071100938 @default.
- W4318473003 cites W2072533587 @default.
- W4318473003 cites W2072768963 @default.
- W4318473003 cites W2074546881 @default.
- W4318473003 cites W2078454159 @default.
- W4318473003 cites W2088238914 @default.
- W4318473003 cites W2088672733 @default.
- W4318473003 cites W2089298112 @default.
- W4318473003 cites W2091161969 @default.
- W4318473003 cites W2091658754 @default.
- W4318473003 cites W2093188241 @default.
- W4318473003 cites W2093922073 @default.