FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318476488> ?p ?o ?g. }

• W4318476488 endingPage "201" @default.
• W4318476488 startingPage "201" @default.
• W4318476488 abstract "The severity of the symptoms associated with COVID-19 is highly variable, and has been associated with circulating amino acids as a group of analytes in metabolomic studies. However, for each individual amino acid, there are discordant results among studies. The aims of the present study were: (i) to investigate the association between COVID-19-symptom severity and circulating amino-acid concentrations; and (ii) to assess the ability of circulating amino-acid levels to predict adverse outcomes (intensive-care-unit admission or hospital death). We studied a sample of 736 participants from the Biobanque Québécoise COVID-19. All participants tested positive for COVID-19, and the severity of symptoms was determined using the World-Health-Organization criteria. Circulating amino acids were measured by HPLC-MS/MS. We used logistic models to assess the association between circulating amino acids concentrations and the odds of presenting mild vs. severe or mild vs. moderate symptoms, as well as their accuracy in predicting adverse outcomes. Patients with severe COVID-19 symptoms were older on average, and they had a higher prevalence of obesity and type 2 diabetes. Out of 20 amino acids tested, 16 were significantly associated with disease severity, with phenylalanine (positively) and cysteine (inversely) showing the strongest associations. These associations remained significant after adjustment for age, sex and body mass index. Phenylalanine had a fair ability to predict the occurrence of adverse outcomes, similar to traditionally measured laboratory variables. A multivariate model including both circulating amino acids and clinical variables had a 90% accuracy at predicting adverse outcomes in this sample. In conclusion, patients presenting severe COVID-19 symptoms have an altered amino-acid profile, compared to those with mild or moderate symptoms." @default.
• W4318476488 created "2023-01-30" @default.
• W4318476488 creator A5009728510 @default.
• W4318476488 creator A5071370188 @default.
• W4318476488 creator A5071489283 @default.
• W4318476488 creator A5077629991 @default.
• W4318476488 creator A5079480540 @default.
• W4318476488 date "2023-01-29" @default.
• W4318476488 modified "2023-10-03" @default.
• W4318476488 title "Association between Circulating Amino Acids and COVID-19 Severity" @default.
• W4318476488 cites W1675221086 @default.
• W4318476488 cites W2290380888 @default.
• W4318476488 cites W2539494034 @default.
• W4318476488 cites W2900038655 @default.
• W4318476488 cites W2970003203 @default.
• W4318476488 cites W3007363313 @default.
• W4318476488 cites W3009885589 @default.
• W4318476488 cites W3009917784 @default.
• W4318476488 cites W3016126001 @default.
• W4318476488 cites W3028711203 @default.
• W4318476488 cites W3035011439 @default.
• W4318476488 cites W3084111371 @default.
• W4318476488 cites W3100375649 @default.
• W4318476488 cites W3117057206 @default.
• W4318476488 cites W3129411309 @default.
• W4318476488 cites W3135288125 @default.
• W4318476488 cites W3139170447 @default.
• W4318476488 cites W3156848737 @default.
• W4318476488 cites W3162558207 @default.
• W4318476488 cites W3182447987 @default.
• W4318476488 cites W3187000649 @default.
• W4318476488 cites W3191777976 @default.
• W4318476488 cites W3196610164 @default.
• W4318476488 cites W3196841487 @default.
• W4318476488 cites W3198570469 @default.
• W4318476488 cites W3201878827 @default.
• W4318476488 cites W3210411341 @default.
• W4318476488 cites W4284974999 @default.
• W4318476488 doi "https://doi.org/10.3390/metabo13020201" @default.
• W4318476488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36837819" @default.
• W4318476488 hasPublicationYear "2023" @default.
• W4318476488 type Work @default.
• W4318476488 citedByCount "2" @default.
• W4318476488 countsByYear W43184764882023 @default.
• W4318476488 crossrefType "journal-article" @default.
• W4318476488 hasAuthorship W4318476488A5009728510 @default.
• W4318476488 hasAuthorship W4318476488A5071370188 @default.
• W4318476488 hasAuthorship W4318476488A5071489283 @default.
• W4318476488 hasAuthorship W4318476488A5077629991 @default.
• W4318476488 hasAuthorship W4318476488A5079480540 @default.
• W4318476488 hasBestOaLocation W43184764881 @default.
• W4318476488 hasConcept C126322002 @default.
• W4318476488 hasConcept C134018914 @default.
• W4318476488 hasConcept C151956035 @default.
• W4318476488 hasConcept C156957248 @default.
• W4318476488 hasConcept C2777431362 @default.
• W4318476488 hasConcept C2780221984 @default.
• W4318476488 hasConcept C30036603 @default.
• W4318476488 hasConcept C515207424 @default.
• W4318476488 hasConcept C55493867 @default.
• W4318476488 hasConcept C555293320 @default.
• W4318476488 hasConcept C71924100 @default.
• W4318476488 hasConcept C86803240 @default.
• W4318476488 hasConceptScore W4318476488C126322002 @default.
• W4318476488 hasConceptScore W4318476488C134018914 @default.
• W4318476488 hasConceptScore W4318476488C151956035 @default.
• W4318476488 hasConceptScore W4318476488C156957248 @default.
• W4318476488 hasConceptScore W4318476488C2777431362 @default.
• W4318476488 hasConceptScore W4318476488C2780221984 @default.
• W4318476488 hasConceptScore W4318476488C30036603 @default.
• W4318476488 hasConceptScore W4318476488C515207424 @default.
• W4318476488 hasConceptScore W4318476488C55493867 @default.
• W4318476488 hasConceptScore W4318476488C555293320 @default.
• W4318476488 hasConceptScore W4318476488C71924100 @default.
• W4318476488 hasConceptScore W4318476488C86803240 @default.
• W4318476488 hasIssue "2" @default.
• W4318476488 hasLocation W43184764881 @default.
• W4318476488 hasLocation W43184764882 @default.
• W4318476488 hasLocation W43184764883 @default.
• W4318476488 hasOpenAccess W4318476488 @default.
• W4318476488 hasPrimaryLocation W43184764881 @default.
• W4318476488 hasRelatedWork W1563850031 @default.
• W4318476488 hasRelatedWork W1981229103 @default.
• W4318476488 hasRelatedWork W1999370887 @default.
• W4318476488 hasRelatedWork W2013155661 @default.
• W4318476488 hasRelatedWork W2030935241 @default.
• W4318476488 hasRelatedWork W2034910577 @default.
• W4318476488 hasRelatedWork W2054931963 @default.
• W4318476488 hasRelatedWork W2336084597 @default.
• W4318476488 hasRelatedWork W2415759662 @default.
• W4318476488 hasRelatedWork W3036934084 @default.
• W4318476488 hasVolume "13" @default.
• W4318476488 isParatext "false" @default.
• W4318476488 isRetracted "false" @default.
• W4318476488 workType "article" @default.