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• W4318478223 abstract "Abstract Magnetic Resonance Imaging of hard biological tissues is very challenging due to small proton abundance and ultra-short $$T_2$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msub> <mml:mi>T</mml:mi> <mml:mn>2</mml:mn> </mml:msub> </mml:math> decay times, especially at low magnetic fields, where sample magnetization is weak. While several pulse sequences, such as Ultra-short Echo Time (UTE), Zero Echo Time (ZTE) and SWeep Imaging with Fourier Transformation (SWIFT), have been developed to cope with ultra-short lived MR signals, only the latter two hold promise of imaging tissues with sub-millisecond $$T_2$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msub> <mml:mi>T</mml:mi> <mml:mn>2</mml:mn> </mml:msub> </mml:math> times at low fields. All these sequences are intrinsically volumetric, thus 3D, because standard slice selection using a long soft radio-frequency pulse is incompatible with ultra-short lived signals. The exception is UTE, where double half pulses can perform slice selection, although at the cost of doubling the acquisition time. Here we demonstrate that spin-locking is a versatile and robust method for slice selection for ultra-short lived signals, and present three ways of combining this pulse sequence with ZTE imaging of the selected slice. With these tools, we demonstrate slice-selected 2D ex vivo imaging of the hardest tissues in the body at low field (260 mT) within clinically acceptable times." @default.
• W4318478223 created "2023-01-30" @default.
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• W4318478223 date "2023-01-30" @default.
• W4318478223 modified "2023-10-09" @default.
• W4318478223 title "Low field slice-selective ZTE imaging of ultra-short $$T_2$$ tissues based on spin-locking" @default.
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• W4318478223 doi "https://doi.org/10.1038/s41598-023-28640-x" @default.
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