FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318479890> ?p ?o ?g. }

• W4318479890 endingPage "420" @default.
• W4318479890 startingPage "420" @default.
• W4318479890 abstract "Modeling Alzheimer's disease (AD) using human-induced pluripotent stem cells (iPSCs) is a field now spanning 15 years. Developments in the field have shown a shift in using simple 2D cortical neuron models to more advanced tri-cultures and 3D cerebral organoids that recapitulate more features of the disease. This is largely due to development and optimization of new cell protocols. In this review, we highlight recent major breakthroughs in the AD field and the implications this has in modeling AD using iPSCs (AD-iPSCs). To date, AD-iPSCs have been largely used to recapitulate and study impaired amyloid precursor protein (APP) processing and tau phosphorylation in both familial and sporadic AD. AD-iPSCs have also been studied for varying neuronal and glial dysfunctions. Moreover, they have been useful for discovering new molecular mechanisms, such as identifying proteins that bridge APP processing with tau phosphorylation and for identifying molecular pathways that bridge APP processing dysfunction with impaired cholesterol biosynthesis. Perhaps the greatest use of AD-iPSCs has been in discovering compounds via drug screening, that reduce amyloid beta (Aβ) in neurons, such as the anti-inflammatory compound, cromolyn, and antiparasitic drugs, avermectins. In addition, high content screening using AD-iPSCs has led to the identification of statins that can reduce levels of phosphorylated tau (p-Tau) in neurons. Some of these compounds have made it through to testing in human clinical trials. Improvements in omic technologies including single cell RNA sequencing and proteomics as well as advances in production of iPSC-cerebral organoids and tri-cultures is likely to result in the further discovery of new drugs and treatments for AD. Some caveats remain in the field, including, long experimental conditions to create mature neurons, high costs of media that limit research capabilities, and a lack of reproducibility using current iPSC-cerebral organoid protocols. Despite these current limitations, AD-iPSCs remain an excellent cellular model for studying AD mechanisms and for drug discovery." @default.
• W4318479890 created "2023-01-30" @default.
• W4318479890 creator A5014115346 @default.
• W4318479890 creator A5084623383 @default.
• W4318479890 date "2023-01-27" @default.
• W4318479890 modified "2023-10-05" @default.
• W4318479890 title "The Breakthroughs and Caveats of Using Human Pluripotent Stem Cells in Modeling Alzheimer’s Disease" @default.
• W4318479890 cites W137425299 @default.
• W4318479890 cites W1507912961 @default.
• W4318479890 cites W1977570151 @default.
• W4318479890 cites W1990752558 @default.
• W4318479890 cites W1994172268 @default.
• W4318479890 cites W2001854231 @default.
• W4318479890 cites W2006223466 @default.
• W4318479890 cites W2022012597 @default.
• W4318479890 cites W2040027262 @default.
• W4318479890 cites W2076412273 @default.
• W4318479890 cites W2080617887 @default.
• W4318479890 cites W2081331575 @default.
• W4318479890 cites W2087786585 @default.
• W4318479890 cites W2088714934 @default.
• W4318479890 cites W2131108668 @default.
• W4318479890 cites W2138456699 @default.
• W4318479890 cites W2138574694 @default.
• W4318479890 cites W2142046859 @default.
• W4318479890 cites W2145882488 @default.
• W4318479890 cites W2157073241 @default.
• W4318479890 cites W2159188744 @default.
• W4318479890 cites W2159422594 @default.
• W4318479890 cites W2159838014 @default.
• W4318479890 cites W2314634699 @default.
• W4318479890 cites W2396426530 @default.
• W4318479890 cites W2488340392 @default.
• W4318479890 cites W2515262002 @default.
• W4318479890 cites W2519209219 @default.
• W4318479890 cites W2558650766 @default.
• W4318479890 cites W2560871830 @default.
• W4318479890 cites W2582868206 @default.
• W4318479890 cites W2586240328 @default.
• W4318479890 cites W2589029485 @default.
• W4318479890 cites W2591588573 @default.
• W4318479890 cites W2593638094 @default.
• W4318479890 cites W2601518322 @default.
• W4318479890 cites W2605401453 @default.
• W4318479890 cites W2755825610 @default.
• W4318479890 cites W2766242602 @default.
• W4318479890 cites W2769598455 @default.
• W4318479890 cites W2769606714 @default.
• W4318479890 cites W2772969939 @default.
• W4318479890 cites W2774947569 @default.
• W4318479890 cites W2789861219 @default.
• W4318479890 cites W2794390181 @default.
• W4318479890 cites W2798230823 @default.
• W4318479890 cites W2799389402 @default.
• W4318479890 cites W2800420110 @default.
• W4318479890 cites W2801804366 @default.
• W4318479890 cites W2805798400 @default.
• W4318479890 cites W2806280791 @default.
• W4318479890 cites W2809913775 @default.
• W4318479890 cites W2887980327 @default.
• W4318479890 cites W2889449128 @default.
• W4318479890 cites W2910508414 @default.
• W4318479890 cites W2911248861 @default.
• W4318479890 cites W2911701742 @default.
• W4318479890 cites W2914222102 @default.
• W4318479890 cites W2914576615 @default.
• W4318479890 cites W2917543658 @default.
• W4318479890 cites W2922895976 @default.
• W4318479890 cites W2934961672 @default.
• W4318479890 cites W2937299859 @default.
• W4318479890 cites W2937882491 @default.
• W4318479890 cites W2943828894 @default.
• W4318479890 cites W2944738928 @default.
• W4318479890 cites W2967807085 @default.
• W4318479890 cites W2969396388 @default.
• W4318479890 cites W2984318880 @default.
• W4318479890 cites W2989784226 @default.
• W4318479890 cites W2992371953 @default.
• W4318479890 cites W3007080627 @default.
• W4318479890 cites W3009274903 @default.
• W4318479890 cites W3016616953 @default.
• W4318479890 cites W3022539327 @default.
• W4318479890 cites W3029808235 @default.
• W4318479890 cites W3033403703 @default.
• W4318479890 cites W3037614667 @default.
• W4318479890 cites W3038196404 @default.
• W4318479890 cites W3044214714 @default.
• W4318479890 cites W3047054604 @default.
• W4318479890 cites W3049616059 @default.
• W4318479890 cites W3092697399 @default.
• W4318479890 cites W3095784700 @default.
• W4318479890 cites W3109942090 @default.
• W4318479890 cites W3118272853 @default.
• W4318479890 cites W3118278361 @default.
• W4318479890 cites W3126038594 @default.
• W4318479890 cites W3126430047 @default.
• W4318479890 cites W3128428002 @default.
• W4318479890 cites W3130500589 @default.

• next