Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318484053> ?p ?o ?g. }
- W4318484053 abstract "This study presents the design, development, and optimization of multifunctional Doxorubicin (Dox)-loaded Indocyanine Green (ICG) proniosomal gel-derived niosomes, using Design of Experiments (23 factorial model). Herein, the multifunctional proniosomal gel was prepared using the coacervation phase separation technique, which on hydration forms niosomes. The effect of formulation variables on various responses including Zeta potential, Vesicle size, entrapment efficiency of Dox, entrapment efficiency of ICG, Invitro drug release at 72nd hour, and NIR hyperthermia temperature were studied using statistical models. On the basis of the high desirability factor, optimized formulation variables were identified and validated with the experimental results. Further, the chemical nature, vesicle morphology, surface charge, and vesicle size of optimized proniosomal gel-derived niosomes were evaluated. In addition, the effect of free ICG and bound ICG on NIR hyperthermia efficiency has been investigated to demonstrate the heating rate and stability of ICG in the aqueous environment and increased temperature conditions. The drug release and kinetic studies revealed a controlled biphasic release profile with complex mechanisms of drug transport for optimized proniosomal gel-derived niosomes. The potential cytotoxic effect of the optimised formulation was also demonstrated invitro using HeLa cell lines." @default.
- W4318484053 created "2023-01-30" @default.
- W4318484053 creator A5010183625 @default.
- W4318484053 creator A5014927967 @default.
- W4318484053 creator A5037644508 @default.
- W4318484053 creator A5043766075 @default.
- W4318484053 creator A5047597448 @default.
- W4318484053 creator A5052243249 @default.
- W4318484053 creator A5057057039 @default.
- W4318484053 date "2023-01-30" @default.
- W4318484053 modified "2023-09-26" @default.
- W4318484053 title "Design development and optimisation of multifunctional Doxorubicin-loaded Indocynanine Green proniosomal gel derived niosomes for tumour management" @default.
- W4318484053 cites W1128029328 @default.
- W4318484053 cites W1900239988 @default.
- W4318484053 cites W1966366087 @default.
- W4318484053 cites W1968927007 @default.
- W4318484053 cites W2034459082 @default.
- W4318484053 cites W2048048172 @default.
- W4318484053 cites W2051361493 @default.
- W4318484053 cites W2051925512 @default.
- W4318484053 cites W2090579879 @default.
- W4318484053 cites W2096240924 @default.
- W4318484053 cites W2098562002 @default.
- W4318484053 cites W2099585828 @default.
- W4318484053 cites W2106810178 @default.
- W4318484053 cites W2123076457 @default.
- W4318484053 cites W2137925863 @default.
- W4318484053 cites W2157822180 @default.
- W4318484053 cites W2171040689 @default.
- W4318484053 cites W2318433991 @default.
- W4318484053 cites W2328903135 @default.
- W4318484053 cites W2332568113 @default.
- W4318484053 cites W2346957939 @default.
- W4318484053 cites W2399638512 @default.
- W4318484053 cites W2555698855 @default.
- W4318484053 cites W2727540510 @default.
- W4318484053 cites W2743736876 @default.
- W4318484053 cites W2891183805 @default.
- W4318484053 cites W2893211277 @default.
- W4318484053 cites W2898076159 @default.
- W4318484053 cites W2904160357 @default.
- W4318484053 cites W2912111325 @default.
- W4318484053 cites W2921508033 @default.
- W4318484053 cites W2924968160 @default.
- W4318484053 cites W2960064588 @default.
- W4318484053 cites W3008673236 @default.
- W4318484053 cites W3010327875 @default.
- W4318484053 cites W3024311661 @default.
- W4318484053 cites W3037868363 @default.
- W4318484053 cites W3081996237 @default.
- W4318484053 cites W3088547513 @default.
- W4318484053 cites W3107501539 @default.
- W4318484053 cites W3137376641 @default.
- W4318484053 cites W3193729404 @default.
- W4318484053 doi "https://doi.org/10.1038/s41598-023-28891-8" @default.
- W4318484053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36717736" @default.
- W4318484053 hasPublicationYear "2023" @default.
- W4318484053 type Work @default.
- W4318484053 citedByCount "0" @default.
- W4318484053 crossrefType "journal-article" @default.
- W4318484053 hasAuthorship W4318484053A5010183625 @default.
- W4318484053 hasAuthorship W4318484053A5014927967 @default.
- W4318484053 hasAuthorship W4318484053A5037644508 @default.
- W4318484053 hasAuthorship W4318484053A5043766075 @default.
- W4318484053 hasAuthorship W4318484053A5047597448 @default.
- W4318484053 hasAuthorship W4318484053A5052243249 @default.
- W4318484053 hasAuthorship W4318484053A5057057039 @default.
- W4318484053 hasBestOaLocation W43184840531 @default.
- W4318484053 hasConcept C130316041 @default.
- W4318484053 hasConcept C155672457 @default.
- W4318484053 hasConcept C171250308 @default.
- W4318484053 hasConcept C185154212 @default.
- W4318484053 hasConcept C185592680 @default.
- W4318484053 hasConcept C192562407 @default.
- W4318484053 hasConcept C41625074 @default.
- W4318484053 hasConcept C43617362 @default.
- W4318484053 hasConcept C55493867 @default.
- W4318484053 hasConcept C72918618 @default.
- W4318484053 hasConcept C86181022 @default.
- W4318484053 hasConceptScore W4318484053C130316041 @default.
- W4318484053 hasConceptScore W4318484053C155672457 @default.
- W4318484053 hasConceptScore W4318484053C171250308 @default.
- W4318484053 hasConceptScore W4318484053C185154212 @default.
- W4318484053 hasConceptScore W4318484053C185592680 @default.
- W4318484053 hasConceptScore W4318484053C192562407 @default.
- W4318484053 hasConceptScore W4318484053C41625074 @default.
- W4318484053 hasConceptScore W4318484053C43617362 @default.
- W4318484053 hasConceptScore W4318484053C55493867 @default.
- W4318484053 hasConceptScore W4318484053C72918618 @default.
- W4318484053 hasConceptScore W4318484053C86181022 @default.
- W4318484053 hasIssue "1" @default.
- W4318484053 hasLocation W43184840531 @default.
- W4318484053 hasLocation W43184840532 @default.
- W4318484053 hasLocation W43184840533 @default.
- W4318484053 hasOpenAccess W4318484053 @default.
- W4318484053 hasPrimaryLocation W43184840531 @default.
- W4318484053 hasRelatedWork W1981861511 @default.
- W4318484053 hasRelatedWork W1999011348 @default.
- W4318484053 hasRelatedWork W2013920045 @default.
- W4318484053 hasRelatedWork W2099535235 @default.