FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318499359> ?p ?o ?g. }

• W4318499359 abstract "Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease. Despite intensive research, considerable NAFLD development remains to be revealed. In this study, we examined the effects of vitamin D on age-induced NAFLD, especially in connection with mitochondrial abnormalities. We observed effective prevention of liver steatosis in 22-month-old C57BL/6 mice fed a vitamin D 3 -supplemented (20,000 IU/kg) diet, in contrast to mice fed a control (1,000 IU/kg) diet. We evaluated whether vitamin D 3 supplementation enhanced mitochondrial functions and found that the mitochondrial contact site and cristae organizing system (MICOS) 60 (Mic60) level was reduced and was specifically restored by vitamin D 3 supplementation in the aged mice. In addition, depletion of Immt , the human gene encoding the Mic60 protein, induced changes in gene expression that led to fat accumulation in HepG2 human hepatocellular carcinoma cells, which is effectively prevented by vitamin D 3 supplementation. In contrast, silencing of Lonp1 , the main matrix protease involved in mitochondrial quality control system and also expressed at a reduced level in aged mice, did not induce triglyceride (TG) accumulation in HepG2 cells. Moreover, VDR-RXR increased Mic60 levels by directly binding to the Immt 5' promoter region spanning from position − 3157 to -2323. Our study demonstrates, for the first time, that a reduction in Mic60 level due to aging may be one of the underlying mechanisms to development aging-associated NAFLD. In addition, vitamin D 3 could positively regulate Mic60 expression, which may be one of the important molecular mechanisms that vitamin D could ameliorate age induced NAFLD." @default.
• W4318499359 created "2023-01-30" @default.
• W4318499359 creator A5021833835 @default.
• W4318499359 creator A5024242144 @default.
• W4318499359 creator A5028397043 @default.
• W4318499359 creator A5048166825 @default.
• W4318499359 creator A5091404286 @default.
• W4318499359 date "2023-01-30" @default.
• W4318499359 modified "2023-10-16" @default.
• W4318499359 title "Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level." @default.
• W4318499359 cites W1480113445 @default.
• W4318499359 cites W1932855763 @default.
• W4318499359 cites W1975521267 @default.
• W4318499359 cites W1979489548 @default.
• W4318499359 cites W1986760556 @default.
• W4318499359 cites W2003465607 @default.
• W4318499359 cites W2013255538 @default.
• W4318499359 cites W2017851530 @default.
• W4318499359 cites W2018713684 @default.
• W4318499359 cites W2027702891 @default.
• W4318499359 cites W2039381033 @default.
• W4318499359 cites W2044213834 @default.
• W4318499359 cites W2057445384 @default.
• W4318499359 cites W2069869036 @default.
• W4318499359 cites W2080115272 @default.
• W4318499359 cites W2095591310 @default.
• W4318499359 cites W2098940158 @default.
• W4318499359 cites W2114065979 @default.
• W4318499359 cites W2132961868 @default.
• W4318499359 cites W2136493937 @default.
• W4318499359 cites W2137250940 @default.
• W4318499359 cites W2141225777 @default.
• W4318499359 cites W2179748167 @default.
• W4318499359 cites W2188930232 @default.
• W4318499359 cites W2269880005 @default.
• W4318499359 cites W2312805753 @default.
• W4318499359 cites W2468250250 @default.
• W4318499359 cites W2473313763 @default.
• W4318499359 cites W2507704409 @default.
• W4318499359 cites W2519839088 @default.
• W4318499359 cites W2552202209 @default.
• W4318499359 cites W2562039591 @default.
• W4318499359 cites W2586648405 @default.
• W4318499359 cites W2588311599 @default.
• W4318499359 cites W2741709190 @default.
• W4318499359 cites W2747913521 @default.
• W4318499359 cites W2787190115 @default.
• W4318499359 cites W2789640615 @default.
• W4318499359 cites W2791108752 @default.
• W4318499359 cites W2802778144 @default.
• W4318499359 cites W2805958828 @default.
• W4318499359 cites W2807255399 @default.
• W4318499359 cites W2810629608 @default.
• W4318499359 cites W2944128273 @default.
• W4318499359 cites W2945577920 @default.
• W4318499359 cites W2994851768 @default.
• W4318499359 cites W3005389576 @default.
• W4318499359 cites W3006028518 @default.
• W4318499359 cites W3013250061 @default.
• W4318499359 cites W3036656295 @default.
• W4318499359 cites W3048737079 @default.
• W4318499359 cites W3112222976 @default.
• W4318499359 cites W3127437208 @default.
• W4318499359 cites W3134630041 @default.
• W4318499359 cites W3137519286 @default.
• W4318499359 cites W3163982066 @default.
• W4318499359 cites W3195162445 @default.
• W4318499359 cites W4220768052 @default.
• W4318499359 cites W4226140746 @default.
• W4318499359 cites W4285740632 @default.
• W4318499359 doi "https://doi.org/10.21203/rs.3.rs-2437531/v1" @default.
• W4318499359 hasPublicationYear "2023" @default.
• W4318499359 type Work @default.
• W4318499359 citedByCount "0" @default.
• W4318499359 crossrefType "posted-content" @default.
• W4318499359 hasAuthorship W4318499359A5021833835 @default.
• W4318499359 hasAuthorship W4318499359A5024242144 @default.
• W4318499359 hasAuthorship W4318499359A5028397043 @default.
• W4318499359 hasAuthorship W4318499359A5048166825 @default.
• W4318499359 hasAuthorship W4318499359A5091404286 @default.
• W4318499359 hasBestOaLocation W43184993591 @default.
• W4318499359 hasConcept C109523444 @default.
• W4318499359 hasConcept C124490489 @default.
• W4318499359 hasConcept C126322002 @default.
• W4318499359 hasConcept C134018914 @default.
• W4318499359 hasConcept C2776175330 @default.
• W4318499359 hasConcept C2776940978 @default.
• W4318499359 hasConcept C2776954865 @default.
• W4318499359 hasConcept C2778163477 @default.
• W4318499359 hasConcept C2778772119 @default.
• W4318499359 hasConcept C2778913445 @default.
• W4318499359 hasConcept C2779134260 @default.
• W4318499359 hasConcept C28859421 @default.
• W4318499359 hasConcept C71924100 @default.
• W4318499359 hasConcept C86803240 @default.
• W4318499359 hasConcept C95444343 @default.
• W4318499359 hasConceptScore W4318499359C109523444 @default.
• W4318499359 hasConceptScore W4318499359C124490489 @default.
• W4318499359 hasConceptScore W4318499359C126322002 @default.
• W4318499359 hasConceptScore W4318499359C134018914 @default.

• next