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- W4318542702 abstract "Ligand-gated ion channels (LGICs) are important regulators of neuromuscular function, making them attractive antiparasitic drug targets. While roundworm LGICs are targeted by several anthelmintic classes, flatworm LGICs are less studied. Chromosome-level genome assemblies have recently been released for Schistosoma flatworm species that cause the disease schistosomiasis. These have allowed us to comprehensively predict schistosome LGICs, adding to prior annotations. Analysis of LGIC sequences revealed a clade of receptors lacking cysteines at the eponymous Cys-loop region of the channel. Since these atypical channels are divergent from mammalian LGICs, they may be promising targets to treat diseases caused by parasitic flatworms." @default.
- W4318542702 created "2023-01-31" @default.
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- W4318542702 date "2023-01-01" @default.
- W4318542702 modified "2023-10-18" @default.
- W4318542702 title "Schistosomes contain divergent ligand-gated ion channels with an atypical Cys-loop motif." @default.
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- W4318542702 doi "https://doi.org/10.17912/micropub.biology.000694" @default.
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