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- W4318543004 abstract "Despite the significant burden, cost, and worse prognosis of Alzheimer's Disease (AD) with Behavioral and Psychological Symptoms of Dementia (BPSD), little is known about the molecular causes of these symptoms. Using antemortem assessments of BPSD in AD, we demonstrate that individual BPSD can be grouped into 4 domain factors in our sample: Affective, Apathy, Agitation, and Psychosis. Then, we performed a transcriptome-wide analysis for each domain utilizing bulk RNA-seq of post-mortem Anterior Cingulate Cortex (ACC) tissue. Though all 4 domains are associated with a predominantly downregulated pattern of hundreds of DEGs, most DEGs are unique to each domain, with only 22 DEGs being common to all BPSD domains, including TIMP1. Weighted Gene Co-Expression Network Analysis (WGCNA) yielded multiple transcriptional modules that were shared between BPSD domains or unique to each domain, and NetDecoder was used to analyze context-dependent information flow through the biological network. For the agitation domain, we found that all DEGs and a highly correlated transcriptional module were functionally enriched for ECM-related genes including TIMP1, TAGLN, and FLNA. Another unique transcriptional module also associated with the agitation domain was enriched with genes involved in post-synaptic signaling, including DRD1, PDE1B, CAMK4, and GABRA4. By comparing context-dependent changes in DEGs between cases and control networks, ESR1 and PARK2 were implicated as two high impact genes associated with agitation that mediated significant information flow through the biological network. Overall, our work establishes unique targets for future study of the biological mechanisms of BPSD and resultant drug development." @default.
- W4318543004 created "2023-01-31" @default.
- W4318543004 creator A5001702447 @default.
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- W4318543004 creator A5044115597 @default.
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- W4318543004 creator A5046675486 @default.
- W4318543004 creator A5061006840 @default.
- W4318543004 creator A5068106731 @default.
- W4318543004 date "2023-01-11" @default.
- W4318543004 modified "2023-09-29" @default.
- W4318543004 title "Unique Transcriptional Signatures Correlate with Behavioral and Psychological Symptom Domains in Alzheimer’s Disease" @default.
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