Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318586449> ?p ?o ?g. }
- W4318586449 endingPage "817" @default.
- W4318586449 startingPage "817" @default.
- W4318586449 abstract "Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies and is one of the major causes of cancer-related death. Over the last 15 years, the molecular landscape of HCC has been deciphered, with the identification of the main driver genes of liver carcinogenesis that belong to six major biological pathways, such as telomere maintenance, Wnt/b-catenin, P53/cell cycle regulation, oxidative stress, epigenetic modifiers, AKT/mTOR and MAP kinase. The combination of genetic and transcriptomic data composed various HCC subclasses strongly related to risk factors, pathological features and prognosis. However, translation into clinical practice is not achieved, mainly because the most frequently mutated genes are undruggable. Moreover, the results derived from the analysis of a single tissue sample may not adequately catch the intra- and intertumor heterogeneity. The analysis of circulating tumor DNA (ctDNA) is broadly developed in other types of cancer for early diagnosis, prognosis and monitoring under systemic treatment in order to identify primary and secondary mechanisms of resistance. The aim of this review is to describe recent data about the HCC molecular landscape and to discuss how ctDNA could be used in the future for HCC detection and management." @default.
- W4318586449 created "2023-01-31" @default.
- W4318586449 creator A5038343376 @default.
- W4318586449 creator A5050786916 @default.
- W4318586449 creator A5056741055 @default.
- W4318586449 date "2023-01-28" @default.
- W4318586449 modified "2023-10-17" @default.
- W4318586449 title "Genetics of Hepatocellular Carcinoma: From Tumor to Circulating DNA" @default.
- W4318586449 cites W1821381892 @default.
- W4318586449 cites W1933489985 @default.
- W4318586449 cites W1967304777 @default.
- W4318586449 cites W1972187528 @default.
- W4318586449 cites W2002960320 @default.
- W4318586449 cites W2011947342 @default.
- W4318586449 cites W2015619266 @default.
- W4318586449 cites W2018080595 @default.
- W4318586449 cites W2018851752 @default.
- W4318586449 cites W2023815439 @default.
- W4318586449 cites W2031709894 @default.
- W4318586449 cites W2035794058 @default.
- W4318586449 cites W2038625523 @default.
- W4318586449 cites W2038831349 @default.
- W4318586449 cites W2044136402 @default.
- W4318586449 cites W2045380897 @default.
- W4318586449 cites W2045402712 @default.
- W4318586449 cites W2047039797 @default.
- W4318586449 cites W2048177238 @default.
- W4318586449 cites W2060043441 @default.
- W4318586449 cites W2060278601 @default.
- W4318586449 cites W2062109911 @default.
- W4318586449 cites W2068127752 @default.
- W4318586449 cites W2083974327 @default.
- W4318586449 cites W2084117221 @default.
- W4318586449 cites W2089135124 @default.
- W4318586449 cites W2095943598 @default.
- W4318586449 cites W2104641188 @default.
- W4318586449 cites W2116731538 @default.
- W4318586449 cites W2132311321 @default.
- W4318586449 cites W2134841349 @default.
- W4318586449 cites W2136415416 @default.
- W4318586449 cites W2158378236 @default.
- W4318586449 cites W2259143567 @default.
- W4318586449 cites W2277004004 @default.
- W4318586449 cites W2529771496 @default.
- W4318586449 cites W2530391744 @default.
- W4318586449 cites W2536454389 @default.
- W4318586449 cites W2555116906 @default.
- W4318586449 cites W2559991443 @default.
- W4318586449 cites W2592816381 @default.
- W4318586449 cites W2595038369 @default.
- W4318586449 cites W2612910794 @default.
- W4318586449 cites W2621007144 @default.
- W4318586449 cites W2625559053 @default.
- W4318586449 cites W2625856057 @default.
- W4318586449 cites W2626446213 @default.
- W4318586449 cites W2679248272 @default.
- W4318586449 cites W2754606968 @default.
- W4318586449 cites W2764195238 @default.
- W4318586449 cites W2774536919 @default.
- W4318586449 cites W2780918397 @default.
- W4318586449 cites W2783674487 @default.
- W4318586449 cites W2786388608 @default.
- W4318586449 cites W2790332133 @default.
- W4318586449 cites W2792521300 @default.
- W4318586449 cites W2793543636 @default.
- W4318586449 cites W2794450296 @default.
- W4318586449 cites W2796067155 @default.
- W4318586449 cites W2811138193 @default.
- W4318586449 cites W2889162157 @default.
- W4318586449 cites W2895142476 @default.
- W4318586449 cites W2899265013 @default.
- W4318586449 cites W2903309381 @default.
- W4318586449 cites W2908573150 @default.
- W4318586449 cites W2912600727 @default.
- W4318586449 cites W2922467660 @default.
- W4318586449 cites W2937870159 @default.
- W4318586449 cites W2939485990 @default.
- W4318586449 cites W2942698941 @default.
- W4318586449 cites W2944104549 @default.
- W4318586449 cites W2949377065 @default.
- W4318586449 cites W2952804432 @default.
- W4318586449 cites W2953822009 @default.
- W4318586449 cites W2964930572 @default.
- W4318586449 cites W2979099750 @default.
- W4318586449 cites W2996545337 @default.
- W4318586449 cites W2997319650 @default.
- W4318586449 cites W2999444600 @default.
- W4318586449 cites W3005987050 @default.
- W4318586449 cites W3010409065 @default.
- W4318586449 cites W3011972930 @default.
- W4318586449 cites W3013924915 @default.
- W4318586449 cites W3021453484 @default.
- W4318586449 cites W3032719025 @default.
- W4318586449 cites W3033879864 @default.
- W4318586449 cites W3081019772 @default.
- W4318586449 cites W3081978148 @default.
- W4318586449 cites W3083427612 @default.
- W4318586449 cites W3093530736 @default.