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- W4318594526 abstract "The drug delivery to the lungs for the treatment of diseases has a very long history, and it has become the priority for respiratory care and attracts much rapidly increasing attention for dealing with local and systemic diseases. The pulmonary delivery can offer a number of prominent advantages, including rapid on-site treatment for local diseases, low dose required, avoidance of systemic side effects, suitability for delivery of biologics, and exceptional patient compliance. In order to elongate the time of drug release for continuous treatment of diseases in the lungs, polymers are explored to prepare delivery systems and are engineered as particles of inhalable size. Alginate is a natural polysaccharide with remarkable biocompatibility and has been extensively utilized as an excipient for drug delivery. Recently, Alginate draws research interests as a fresh additive to prepare inhalable particles for pulmonary drug delivery. The major methods to prepare alginate-based inhalable particles consist of the traditional spray-drying, the ionotropic gelation, and the combination of different technologies. The in-vitro aerosolization performance is investigated and alginate-based particles show satisfactory aerodynamic particle size distribution, suggesting an ideal drug delivery to the lungs. For the determination of drug release profiles, a variety of methods have been developed. In comparison with pure drug substance, the particles modified by alginate show a sustained drug release profile, which can elongate the time of drug release from minutes to several days, implying a great potential for drug delivery to the lungs for the continuous treatment of respiratory diseases." @default.
- W4318594526 created "2023-01-31" @default.
- W4318594526 creator A5046245742 @default.
- W4318594526 date "2023-01-01" @default.
- W4318594526 modified "2023-09-30" @default.
- W4318594526 title "Alginate-Based Inhalable Particles for Controlled Pulmonary Drug Delivery" @default.
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- W4318594526 doi "https://doi.org/10.1007/978-981-19-6937-9_9" @default.
- W4318594526 hasPublicationYear "2023" @default.
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